DegronMD

Uniprot ID: P49792

Source protein: E3 SUMO-protein ligase RanBP2

Source gene: RANBP2

Class: DEG_SCF_FBW7_1

Location: 2448:2454

E3 ligase: FBXW7

DEGRON score: 0.9319

ASA_SCORE: 97.3429

COIL: 0.8494

CONS_SCORE: 0.3562

DSS_SCORE: 0.5874

HELIX: 0.0273

FCONS_SCORE: 0.9856

RIG_SCORE: 0.7028

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2442T	TCGA-86-8674	LUAD	TCGA	LITPHVS	DEG_SCF_FBW7_1	0.1667
p.A2442T	DO25535	LUAD	ICGC	LITPHVS	DEG_SCF_FBW7_1	0.1667
p.D2446Y	TCGA-A5-A2K5	UCEC	TCGA	LITPHVS	DEG_SCF_FBW7_1	0.2778
p.D2446Y	TCGA-D1-A17Q	UCEC	TCGA	LITPHVS	DEG_SCF_FBW7_1	0.2778
p.D2446Y	DO41903	UCEC	ICGC	LITPHVS	DEG_SCF_FBW7_1	0.2778
p.D2446Y	DO41379	UCEC	ICGC	LITPHVS	DEG_SCF_FBW7_1	0.2778
p.H2452Y	TCGA-D3-A3MV	SKCM	TCGA	LITPHVS	DEG_SCF_FBW7_1	0.6118
p.H2452Y	DO37727	SKCM	ICGC	LITPHVS	DEG_SCF_FBW7_1	0.6118
p.S2447F	TCGA-EE-A2M6	SKCM	TCGA	LITPHVS	DEG_SCF_FBW7_1	0.75
p.S2447F	DO37976	SKCM	ICGC	LITPHVS	DEG_SCF_FBW7_1	0.75
p.S2447F	SIDM00127	Oral Cavity Carcinoma	GDSC	LITPHVS	DEG_SCF_FBW7_1	0.75
p.S2447F	SIDM01567	Hodgkin's Lymphoma	GDSC	LITPHVS	DEG_SCF_FBW7_1	0.75
p.P2459H	SIDM01943	Colorectal Carcinoma	GDSC	LITPHVS	DEG_SCF_FBW7_1	0.1944
p.S2457G	SIDM01611	Endometrial Carcinoma	GDSC	LITPHVS	DEG_SCF_FBW7_1	0.6944
p.S2457G	ACH-000996	Endometrial/Uterine Cancer	CCLE	LITPHVS	DEG_SCF_FBW7_1	0.6944
p.I2449V	ACH-000990	Endometrial/Uterine Cancer	CCLE	LITPHVS	DEG_SCF_FBW7_1	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49792	E3 SUMO-protein ligase RanBP2	DEG_SCF_FBW7_1	2448:2454	LITPHVS	FBXW7	0.9319	More...
Q99666	RANBP2-like and GRIP domain-containing protein 5/6	DEG_SCF_FBW7_1	1472:1478	LITPHVS	FBXW7	0.9475	More...
A6NKT7	RanBP2-like and GRIP domain-containing protein 3	DEG_SCF_FBW7_1	1473:1479	LITPHVS	FBXW7	0.8721	More...
O14715	RANBP2-like and GRIP domain-containing protein 8	DEG_SCF_FBW7_1	1472:1478	LITPHVS	FBXW7	0.9085	More...
P0DJD0	RANBP2-like and GRIP domain-containing protein 1	DEG_SCF_FBW7_1	1457:1463	LITPHVS	FBXW7	0.8406	More...
P0DJD1	RANBP2-like and GRIP domain-containing protein 2	DEG_SCF_FBW7_1	1465:1471	LITPHVS	FBXW7	0.8004	More...
Q7Z3J3	RanBP2-like and GRIP domain-containing protein 4	DEG_SCF_FBW7_1	1473:1479	LITPHVS	FBXW7	0.9808	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons