DegronMD

Uniprot ID: A6NKT7

Source protein: RanBP2-like and GRIP domain-containing protein 3

Source gene: RGPD3

Class: DEG_SPOP_SBC_1

Location: 976:980

E3 ligase: SPOP

DEGRON score: 0.8902

ASA_SCORE: 70.52

COIL: 0.7044

CONS_SCORE: 0.3601

DSS_SCORE: 0.2423

HELIX: 0.2476

FCONS_SCORE: 1.0742

RIG_SCORE: 0.756

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G987D	TCGA-3N-A9WC	SKCM	TCGA	AKSTS	DEG_SPOP_SBC_1	0.1389
p.G987D	TCGA-IB-7651	PAAD	TCGA	AKSTS	DEG_SPOP_SBC_1	0.1389
p.G987D	DO46657	PAAD	ICGC	AKSTS	DEG_SPOP_SBC_1	0.1389
p.G987D	DO51234	SKCM	ICGC	AKSTS	DEG_SPOP_SBC_1	0.1389
p.S978L	TCGA-BH-A0HF	BRCA	TCGA	AKSTS	DEG_SPOP_SBC_1	0.8778
p.S978L	DO1749	BRCA	ICGC	AKSTS	DEG_SPOP_SBC_1	0.8778
p.T979A	TCGA-BS-A0UJ	UCEC	TCGA	AKSTS	DEG_SPOP_SBC_1	0.825
p.T979A	DO42745	UCEC	ICGC	AKSTS	DEG_SPOP_SBC_1	0.825
p.G983E	TCGA-D3-A3MU	SKCM	TCGA	AKSTS	DEG_SPOP_SBC_1	0.25
p.G983E	TCGA-EB-A41B	SKCM	TCGA	AKSTS	DEG_SPOP_SBC_1	0.25
p.G983E	DO37611	SKCM	ICGC	AKSTS	DEG_SPOP_SBC_1	0.25
p.G983E	DO47337	SKCM	ICGC	AKSTS	DEG_SPOP_SBC_1	0.25
p.K989E	TCGA-EE-A2MJ	SKCM	TCGA	AKSTS	DEG_SPOP_SBC_1	0.1944
p.K989E	DO38099	SKCM	ICGC	AKSTS	DEG_SPOP_SBC_1	0.1944
p.F970L	TCGA-UF-A7JO	HNSC	TCGA	AKSTS	DEG_SPOP_SBC_1	0.1667
p.F970L	DO219088	HNSC	ICGC	AKSTS	DEG_SPOP_SBC_1	0.1667
p.G983R	DO229459	SKCA	ICGC	AKSTS	DEG_SPOP_SBC_1	0.25
p.K988N	DO218912	SKCA	ICGC	AKSTS	DEG_SPOP_SBC_1	0.5556
p.F986Y	SIDM00491	Thyroid Gland Carcinoma	GDSC	AKSTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49792	E3 SUMO-protein ligase RanBP2	DEG_SPOP_SBC_1	1951:1955	AKSTS	SPOP	0.8024	More...
P58304	Visual system homeobox 2	DEG_SPOP_SBC_1	18:22	AKSTS	SPOP	0.9689	More...
Q13480	GRB2-associated-binding protein 1	DEG_SPOP_SBC_1	204:208	AKSTS	SPOP	0.7361	More...
Q8WWL2	Protein spire homolog 2	DEG_SPOP_SBC_1	383:387	AKSTS	SPOP	0.6134	More...
Q9NSC2	Sal-like protein 1	DEG_SPOP_SBC_1	438:442	AKSTS	SPOP	0.9731	More...
A6NKT7	RanBP2-like and GRIP domain-containing protein 3	DEG_SPOP_SBC_1	976:980	AKSTS	SPOP	0.8902	More...
P0DJD0	RANBP2-like and GRIP domain-containing protein 1	DEG_SPOP_SBC_1	960:964	AKSTS	SPOP	0.9976	More...
P0DJD1	RANBP2-like and GRIP domain-containing protein 2	DEG_SPOP_SBC_1	968:972	AKSTS	SPOP	0.9478	More...
Q569K6	Coiled-coil domain-containing protein 157	DEG_SPOP_SBC_1	643:647	AKSTS	SPOP	0.7532	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons