DegronMD - P58304(VSX2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K279N	TCGA-AA-A010	COAD	TCGA	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation altering degron motif	0.5806
p.A27T	TCGA-AD-6895	COAD	TCGA	AKSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1944
p.A27T	DO8938	COAD	ICGC	AKSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1944
p.E271D	TCGA-AJ-A3EK	UCEC	TCGA	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.2778
p.E271D	DO41584	UCEC	ICGC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.2778
p.A276T	TCGA-AJ-A3EK	UCEC	TCGA	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation altering degron motif	0.6028
p.A276T	DO41584	UCEC	ICGC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation altering degron motif	0.6028
p.T30A	TCGA-AU-6004	COAD	TCGA	AKSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1111
p.T30A	DO7780	COAD	ICGC	AKSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1111
p.R268M	TCGA-D1-A103	UCEC	TCGA	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.1944
p.R268M	DO42312	UCEC	ICGC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.1944
p.L280P	TCGA-DD-AADP	LIHC	TCGA	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation altering degron motif	0.7582
p.L280P	DO52243	LIHC	ICGC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation altering degron motif	0.7582
p.L280P	ACH-000974	Endometrial/Uterine Cancer	CCLE	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation altering degron motif	0.7582
p.A8V	TCGA-E6-A2P9	UCEC	TCGA	AKSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.0556
p.A8V	DO43714	UCEC	ICGC	AKSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.0556
p.G272E	TCGA-EE-A29L	SKCM	TCGA	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.3056
p.G272E	DO222599	MELA	ICGC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.3056
p.G272E	DO218863	SKCA	ICGC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.3056
p.G272E	DO37835	SKCM	ICGC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.3056
p.A25P	TCGA-LN-A9FP	ESCA	TCGA	AKSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.25
p.S266L	TCGA-XR-A8TG	LIHC	TCGA	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation blocking phosphorylation signal	0.5833
p.S266L	DO223924	LIHC	ICGC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation blocking phosphorylation signal	0.5833
p.D291N	DO229016	COCA	ICGC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM01006	Plasma Cell Myeloma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM00630	Breast Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM00777	Colorectal Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM00041	Gastric Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM00632	Non-Cancerous	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM00266	Ewing's Sarcoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM00654	Small Cell Lung Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM00741	Small Cell Lung Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM00317	Kidney Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM00194	Colorectal Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM00687	Gastric Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM00450	Acute Myeloid Leukemia	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM01081	Oral Cavity Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM00024	Non-Cancerous	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM00081	Melanoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM00502	B-Lymphoblastic Leukemia	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM00561	Other Blood Cancers	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM01061	Oral Cavity Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM01217	Other Blood Cancers	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM01000	Melanoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM00217	Colorectal Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM00986	Head and Neck Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM01001	Breast Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM00132	Pancreatic Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM00901	Endometrial Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM01686	Chronic Myelogenous Leukemia	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM01498	Acute Myeloid Leukemia	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM01746	Osteosarcoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM01445	Gastric Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.D291N	SIDM01413	Oral Cavity Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.A63V	DO234341	ESAD	ICGC	PRAALDGLA	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.1667
p.A64V	DO234461	ESAD	ICGC	PRAALDGLA	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.1389
p.K269E	DO233780	GACA	ICGC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation substituting flanking lysine	0.3333
p.P49L	DO233926	GACA	ICGC	PRAALDGLA	DEG_APCC_DBOX_1	49:57	Mutation altering degron motif	0.6471
p.G289V	DO229024	LICA	ICGC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.1111
p.A57S	DO229037	LICA	ICGC	PRAALDGLA	DEG_APCC_DBOX_1	49:57	Mutation altering degron motif	0.6477
p.S46T	DO229138	LMS	ICGC	PRAALDGLA	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.25
p.E271K	DO228855	MALY	ICGC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.2778
p.E271K	ACH-000975	Lung Cancer	CCLE	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.2778
p.A25T	DO51472	PACA	ICGC	AKSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.25
p.R65H	SIDM01314	Colorectal Carcinoma	GDSC	PRAALDGLA	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.1111
p.R65H	ACH-000866	Lung Cancer	CCLE	PRAALDGLA	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.1111
p.G272V	SIDM00845	Burkitt's Lymphoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.3056
p.A8S	SIDM00120	Prostate Carcinoma	GDSC	AKSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.0556
p.A8S	ACH-000979	Prostate Cancer	CCLE	AKSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.0556
p.R65C	SIDM01129	Small Cell Lung Carcinoma	GDSC	PRAALDGLA	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.1111
p.R65C	ACH-000816	Lung Cancer	CCLE	PRAALDGLA	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.1111
p.K279T	SIDM00783	Colorectal Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation altering degron motif	0.6195
p.K279T	ACH-000971	Colon/Colorectal Cancer	CCLE	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation altering degron motif	0.6195
p.P290H	ACH-000659	Lung Cancer	CCLE	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0833
p.P290H	ACH-001386	Lung Cancer	CCLE	ERQALPKLD	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0833

Kaplan plot for VSX2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VSX2

UniProt ID: P58304

Entrez ID: 338917

Protein name: Visual system homeobox 2 (Ceh-10 homeodomain-containing homolog) (Homeobox protein CHX10)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VSX2 in