DegronMD

Uniprot ID: P58304

Source protein: Visual system homeobox 2

Source gene: VSX2

Class: DEG_APCC_DBOX_1

Location: 273:281

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5758

ASA_SCORE: 98.4333

COIL: 0.7718

CONS_SCORE: 0.3416

DSS_SCORE: 0.7361

HELIX: 0.194

FCONS_SCORE: 0.9208

RIG_SCORE: 0.6684

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K279N	TCGA-AA-A010	COAD	TCGA	ERQALPKLD	DEG_APCC_DBOX_1	0.5806
p.E271D	TCGA-AJ-A3EK	UCEC	TCGA	ERQALPKLD	DEG_APCC_DBOX_1	0.2778
p.E271D	DO41584	UCEC	ICGC	ERQALPKLD	DEG_APCC_DBOX_1	0.2778
p.A276T	TCGA-AJ-A3EK	UCEC	TCGA	ERQALPKLD	DEG_APCC_DBOX_1	0.6028
p.A276T	DO41584	UCEC	ICGC	ERQALPKLD	DEG_APCC_DBOX_1	0.6028
p.R268M	TCGA-D1-A103	UCEC	TCGA	ERQALPKLD	DEG_APCC_DBOX_1	0.1944
p.R268M	DO42312	UCEC	ICGC	ERQALPKLD	DEG_APCC_DBOX_1	0.1944
p.L280P	TCGA-DD-AADP	LIHC	TCGA	ERQALPKLD	DEG_APCC_DBOX_1	0.7582
p.L280P	DO52243	LIHC	ICGC	ERQALPKLD	DEG_APCC_DBOX_1	0.7582
p.L280P	ACH-000974	Endometrial/Uterine Cancer	CCLE	ERQALPKLD	DEG_APCC_DBOX_1	0.7582
p.G272E	TCGA-EE-A29L	SKCM	TCGA	ERQALPKLD	DEG_APCC_DBOX_1	0.3056
p.G272E	DO222599	MELA	ICGC	ERQALPKLD	DEG_APCC_DBOX_1	0.3056
p.G272E	DO218863	SKCA	ICGC	ERQALPKLD	DEG_APCC_DBOX_1	0.3056
p.G272E	DO37835	SKCM	ICGC	ERQALPKLD	DEG_APCC_DBOX_1	0.3056
p.S266L	TCGA-XR-A8TG	LIHC	TCGA	ERQALPKLD	DEG_APCC_DBOX_1	0.5833
p.S266L	DO223924	LIHC	ICGC	ERQALPKLD	DEG_APCC_DBOX_1	0.5833
p.D291N	DO229016	COCA	ICGC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM01006	Plasma Cell Myeloma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM00630	Breast Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM00777	Colorectal Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM00041	Gastric Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM00632	Non-Cancerous	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM00266	Ewing's Sarcoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM00654	Small Cell Lung Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM00741	Small Cell Lung Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM00317	Kidney Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM00194	Colorectal Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM00687	Gastric Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM00450	Acute Myeloid Leukemia	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM01081	Oral Cavity Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM00024	Non-Cancerous	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM00081	Melanoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM00502	B-Lymphoblastic Leukemia	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM00561	Other Blood Cancers	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM01061	Oral Cavity Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM01217	Other Blood Cancers	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM01000	Melanoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM00217	Colorectal Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM00986	Head and Neck Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM01001	Breast Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM00132	Pancreatic Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM00901	Endometrial Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM01686	Chronic Myelogenous Leukemia	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM01498	Acute Myeloid Leukemia	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM01746	Osteosarcoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM01445	Gastric Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.D291N	SIDM01413	Oral Cavity Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.0556
p.K269E	DO233780	GACA	ICGC	ERQALPKLD	DEG_APCC_DBOX_1	0.3333
p.G289V	DO229024	LICA	ICGC	ERQALPKLD	DEG_APCC_DBOX_1	0.1111
p.E271K	DO228855	MALY	ICGC	ERQALPKLD	DEG_APCC_DBOX_1	0.2778
p.E271K	ACH-000975	Lung Cancer	CCLE	ERQALPKLD	DEG_APCC_DBOX_1	0.2778
p.G272V	SIDM00845	Burkitt's Lymphoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.3056
p.K279T	SIDM00783	Colorectal Carcinoma	GDSC	ERQALPKLD	DEG_APCC_DBOX_1	0.6195
p.K279T	ACH-000971	Colon/Colorectal Cancer	CCLE	ERQALPKLD	DEG_APCC_DBOX_1	0.6195
p.P290H	ACH-000659	Lung Cancer	CCLE	ERQALPKLD	DEG_APCC_DBOX_1	0.0833
p.P290H	ACH-001386	Lung Cancer	CCLE	ERQALPKLD	DEG_APCC_DBOX_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERQALPKLD

Degron related mutations and impact score

Drug responses associated with VSX2 mutations

All proteins holding degron of ERQALPKLD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P58304	Visual system homeobox 2	DEG_APCC_DBOX_1	273:281	ERQALPKLD	APC,CDC20,FZR1	0.5758	More...