DegronMD

Uniprot ID: P58304

Source protein: Visual system homeobox 2

Source gene: VSX2

Class: DEG_APCC_DBOX_1

Location: 49:57

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9627

ASA_SCORE: 62.3556

COIL: 0.8139

CONS_SCORE: 0.3944

DSS_SCORE: 0.4745

HELIX: 0.1464

FCONS_SCORE: 0.8358

RIG_SCORE: 0.6995

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A63V	DO234341	ESAD	ICGC	PRAALDGLA	DEG_APCC_DBOX_1	0.1667
p.A64V	DO234461	ESAD	ICGC	PRAALDGLA	DEG_APCC_DBOX_1	0.1389
p.P49L	DO233926	GACA	ICGC	PRAALDGLA	DEG_APCC_DBOX_1	0.6471
p.A57S	DO229037	LICA	ICGC	PRAALDGLA	DEG_APCC_DBOX_1	0.6477
p.S46T	DO229138	LMS	ICGC	PRAALDGLA	DEG_APCC_DBOX_1	0.25
p.R65H	SIDM01314	Colorectal Carcinoma	GDSC	PRAALDGLA	DEG_APCC_DBOX_1	0.1111
p.R65H	ACH-000866	Lung Cancer	CCLE	PRAALDGLA	DEG_APCC_DBOX_1	0.1111
p.R65C	SIDM01129	Small Cell Lung Carcinoma	GDSC	PRAALDGLA	DEG_APCC_DBOX_1	0.1111
p.R65C	ACH-000816	Lung Cancer	CCLE	PRAALDGLA	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P58304	Visual system homeobox 2	DEG_APCC_DBOX_1	49:57	PRAALDGLA	APC,CDC20,FZR1	0.9627	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons