DegronMD

Uniprot ID: Q9NSC2

Source protein: Sal-like protein 1

Source gene: SALL1

Class: DEG_SPOP_SBC_1

Location: 438:442

E3 ligase: SPOP

DEGRON score: 0.9731

ASA_SCORE: 70.72

COIL: 0.7592

CONS_SCORE: 0.3927

DSS_SCORE: 0.3059

HELIX: 0.0708

FCONS_SCORE: 0.7875

RIG_SCORE: 0.7338

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S442F	TCGA-55-6972	LUAD	TCGA	AKSTS	DEG_SPOP_SBC_1	0.7982
p.S442F	DO25010	LUAD	ICGC	AKSTS	DEG_SPOP_SBC_1	0.7982
p.T442I	HEC-1	endometrium	COSMIC	AKSTS	DEG_SPOP_SBC_1	0.7078
p.A438V	TCGA-D1-A103	UCEC	TCGA	AKSTS	DEG_SPOP_SBC_1	0.5825
p.A438V	DO232761	PBCA	ICGC	AKSTS	DEG_SPOP_SBC_1	0.5825
p.A438V	DO42312	UCEC	ICGC	AKSTS	DEG_SPOP_SBC_1	0.5825
p.E444G	DO1199	BRCA	ICGC	AKSTS	DEG_SPOP_SBC_1	0.2778
p.K450M	DO233885	GACA	ICGC	AKSTS	DEG_SPOP_SBC_1	0.2222
p.T434A	SIDM01612	Endometrial Carcinoma	GDSC	AKSTS	DEG_SPOP_SBC_1	0.2222
p.T434A	ACH-000946	Endometrial/Uterine Cancer	CCLE	AKSTS	DEG_SPOP_SBC_1	0.2222
p.V433A	TCGA-LC-A66R	BLCA	TCGA	AKSTS	DEG_SPOP_SBC_1	0.1944
p.V433A	DO44031	BLCA	ICGC	AKSTS	DEG_SPOP_SBC_1	0.1944
p.P431L	TCGA-55-8204	LUAD	TCGA	AKSTS	DEG_SPOP_SBC_1	0.1389
p.P431L	DO45322	LUAD	ICGC	AKSTS	DEG_SPOP_SBC_1	0.1389
p.P431T	TCGA-55-8204	LUAD	TCGA	AKSTS	DEG_SPOP_SBC_1	0.1389
p.P431T	DO45322	LUAD	ICGC	AKSTS	DEG_SPOP_SBC_1	0.1389
p.S428G	SIDM01146	Gastric Carcinoma	GDSC	AKSTS	DEG_SPOP_SBC_1	0.0556
p.S428G	ACH-000932	Gastric Cancer	CCLE	AKSTS	DEG_SPOP_SBC_1	0.0556
p.S428G	NCI-SNU-1	stomach	COSMIC	AKSTS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 19 of 19 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q569K6	Coiled-coil domain-containing protein 157	DEG_SPOP_SBC_1	643:647	AKSTS	SPOP	0.7532	More...
P49792	E3 SUMO-protein ligase RanBP2	DEG_SPOP_SBC_1	1951:1955	AKSTS	SPOP	0.8024	More...
Q13480	GRB2-associated-binding protein 1	DEG_SPOP_SBC_1	204:208	AKSTS	SPOP	0.7361	More...
Q8WWL2	Protein spire homolog 2	DEG_SPOP_SBC_1	383:387	AKSTS	SPOP	0.6134	More...
P0DJD0	RANBP2-like and GRIP domain-containing protein 1	DEG_SPOP_SBC_1	960:964	AKSTS	SPOP	0.9976	More...
P0DJD1	RANBP2-like and GRIP domain-containing protein 2	DEG_SPOP_SBC_1	968:972	AKSTS	SPOP	0.9478	More...
A6NKT7	RanBP2-like and GRIP domain-containing protein 3	DEG_SPOP_SBC_1	976:980	AKSTS	SPOP	0.8902	More...
Q9NSC2	Sal-like protein 1	DEG_SPOP_SBC_1	438:442	AKSTS	SPOP	0.9731	More...
P58304	Visual system homeobox 2	DEG_SPOP_SBC_1	18:22	AKSTS	SPOP	0.9689	More...

Showing 1 to 9 of 9 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons