DegronMD - Q8WWL2(SPIRE2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R333H	TCGA-85-7950	LUSC	TCGA	SRPPLKQVS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.1944
p.R333H	DO26878	LUSC	ICGC	SRPPLKQVS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.1944
p.R333H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	SRPPLKQVS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.1944
p.R333H	ACH-001127	Leukemia	CCLE	SRPPLKQVS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.1944
p.R333H	ACH-001377	Pancreatic Cancer	CCLE	SRPPLKQVS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.1944
p.R333H	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	SRPPLKQVS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.1944
p.C374F	TCGA-DD-A11A	LIHC	TCGA	AKSTS	DEG_SPOP_SBC_1	383:387	Mutation rewiring degron network	0.0833
p.C374F	DO22835	LIHC	ICGC	AKSTS	DEG_SPOP_SBC_1	383:387	Mutation rewiring degron network	0.0833
p.P323A	TCGA-DD-AADP	LIHC	TCGA	SRPPLKQVS	DEG_APCC_DBOX_1	320:328	Mutation altering degron motif	0.6392
p.P323A	DO52243	LIHC	ICGC	SRPPLKQVS	DEG_APCC_DBOX_1	320:328	Mutation altering degron motif	0.6392
p.I318V	TCGA-EE-A180	SKCM	TCGA	SRPPLKQVS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.2778
p.I318V	DO47537	SKCM	ICGC	SRPPLKQVS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.2778
p.S392L	TCGA-EE-A29S	SKCM	TCGA	AKSTS	DEG_SPOP_SBC_1	383:387	Mutation blocking phosphorylation signal	0.6389
p.S392L	DO37936	SKCM	ICGC	AKSTS	DEG_SPOP_SBC_1	383:387	Mutation blocking phosphorylation signal	0.6389
p.D316N	TCGA-FS-A1ZK	SKCM	TCGA	SRPPLKQVS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.2222
p.D316N	DO37474	SKCM	ICGC	SRPPLKQVS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.2222
p.E329Q	TCGA-G2-AA3B	BLCA	TCGA	SRPPLKQVS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.3056
p.E329Q	DO51882	BLCA	ICGC	SRPPLKQVS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.3056
p.D395G	TCGA-L5-A88S	ESCA	TCGA	AKSTS	DEG_SPOP_SBC_1	383:387	Mutation rewiring degron network	0.1111
p.R319H	DO233760	GACA	ICGC	SRPPLKQVS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.3056
p.R319H	DO232224	PBCA	ICGC	SRPPLKQVS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.3056
p.R319H	DO42209	UCEC	ICGC	SRPPLKQVS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.3056
p.R331W	DO233859	GACA	ICGC	SRPPLKQVS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.25
p.L335F	DO228986	LICA	ICGC	SRPPLKQVS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.1389
p.P323S	DO222546	MELA	ICGC	SRPPLKQVS	DEG_APCC_DBOX_1	320:328	Mutation altering degron motif	0.5641
p.P373T	DO229242	THCA	ICGC	AKSTS	DEG_SPOP_SBC_1	383:387	Mutation rewiring degron network	0.0556
p.R333C	SIDM01100	Neuroblastoma	GDSC	SRPPLKQVS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.1944
p.R333C	ACH-000366	Neuroblastoma	CCLE	SRPPLKQVS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.1944
p.R333C	SK-N-DZ	autonomic ganglia	COSMIC	SRPPLKQVS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.1944
p.E312K	SIDM01729	Endometrial Carcinoma	GDSC	SRPPLKQVS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.1111
p.E312K	ACH-000909	Endometrial/Uterine Cancer	CCLE	SRPPLKQVS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.1111

Kaplan plot for SPIRE2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPIRE2

UniProt ID: Q8WWL2

Entrez ID: 84501

Protein name: Protein spire homolog 2 (Spir-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPIRE2 in