DegronMD

Uniprot ID: Q8WWL2

Source protein: Protein spire homolog 2

Source gene: SPIRE2

Class: DEG_APCC_DBOX_1

Location: 320:328

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8612

ASA_SCORE: 87.3556

COIL: 0.699

CONS_SCORE: 0.5515

DSS_SCORE: 0.3825

HELIX: 0.2579

FCONS_SCORE: 1.0374

RIG_SCORE: 0.7065

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R333H	TCGA-85-7950	LUSC	TCGA	SRPPLKQVS	DEG_APCC_DBOX_1	0.1944
p.R333H	DO26878	LUSC	ICGC	SRPPLKQVS	DEG_APCC_DBOX_1	0.1944
p.R333H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	SRPPLKQVS	DEG_APCC_DBOX_1	0.1944
p.R333H	ACH-001127	Leukemia	CCLE	SRPPLKQVS	DEG_APCC_DBOX_1	0.1944
p.R333H	ACH-001377	Pancreatic Cancer	CCLE	SRPPLKQVS	DEG_APCC_DBOX_1	0.1944
p.R333H	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	SRPPLKQVS	DEG_APCC_DBOX_1	0.1944
p.P323A	TCGA-DD-AADP	LIHC	TCGA	SRPPLKQVS	DEG_APCC_DBOX_1	0.6392
p.P323A	DO52243	LIHC	ICGC	SRPPLKQVS	DEG_APCC_DBOX_1	0.6392
p.I318V	TCGA-EE-A180	SKCM	TCGA	SRPPLKQVS	DEG_APCC_DBOX_1	0.2778
p.I318V	DO47537	SKCM	ICGC	SRPPLKQVS	DEG_APCC_DBOX_1	0.2778
p.D316N	TCGA-FS-A1ZK	SKCM	TCGA	SRPPLKQVS	DEG_APCC_DBOX_1	0.2222
p.D316N	DO37474	SKCM	ICGC	SRPPLKQVS	DEG_APCC_DBOX_1	0.2222
p.E329Q	TCGA-G2-AA3B	BLCA	TCGA	SRPPLKQVS	DEG_APCC_DBOX_1	0.3056
p.E329Q	DO51882	BLCA	ICGC	SRPPLKQVS	DEG_APCC_DBOX_1	0.3056
p.R319H	DO233760	GACA	ICGC	SRPPLKQVS	DEG_APCC_DBOX_1	0.3056
p.R319H	DO232224	PBCA	ICGC	SRPPLKQVS	DEG_APCC_DBOX_1	0.3056
p.R319H	DO42209	UCEC	ICGC	SRPPLKQVS	DEG_APCC_DBOX_1	0.3056
p.R331W	DO233859	GACA	ICGC	SRPPLKQVS	DEG_APCC_DBOX_1	0.25
p.L335F	DO228986	LICA	ICGC	SRPPLKQVS	DEG_APCC_DBOX_1	0.1389
p.P323S	DO222546	MELA	ICGC	SRPPLKQVS	DEG_APCC_DBOX_1	0.5641
p.R333C	SIDM01100	Neuroblastoma	GDSC	SRPPLKQVS	DEG_APCC_DBOX_1	0.1944
p.R333C	ACH-000366	Neuroblastoma	CCLE	SRPPLKQVS	DEG_APCC_DBOX_1	0.1944
p.R333C	SK-N-DZ	autonomic_ganglia	COSMIC	SRPPLKQVS	DEG_APCC_DBOX_1	0.1944
p.E312K	SIDM01729	Endometrial Carcinoma	GDSC	SRPPLKQVS	DEG_APCC_DBOX_1	0.1111
p.E312K	ACH-000909	Endometrial/Uterine Cancer	CCLE	SRPPLKQVS	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WWL2	Protein spire homolog 2	DEG_APCC_DBOX_1	320:328	SRPPLKQVS	APC,CDC20,FZR1	0.8612	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRPPLKQVS

Degron related mutations and impact score

Drug responses associated with SPIRE2 mutations

All proteins holding degron of SRPPLKQVS