DegronMD

Uniprot ID: Q13480

Source protein: GRB2-associated-binding protein 1

Source gene: GAB1

Class: DEG_SCF_TRCP1_1

Location: 633:638

E3 ligase: BTRC

DEGRON score: 0.9988

ASA_SCORE: 90.25

COIL: 0.9685

CONS_SCORE: 0.4574

DSS_SCORE: 0.6444

HELIX: 0.013

FCONS_SCORE: 1.0996

RIG_SCORE: 0.6266

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D630V	TCGA-34-5234	LUSC	TCGA	DSGKST	DEG_SCF_TRCP1_1	0.25
p.D630V	DO26810	LUSC	ICGC	DSGKST	DEG_SCF_TRCP1_1	0.25
p.P645H	TCGA-A5-A0G1	UCEC	TCGA	DSGKST	DEG_SCF_TRCP1_1	0.5833
p.P645H	DO42472	UCEC	ICGC	DSGKST	DEG_SCF_TRCP1_1	0.5833
p.N625T	TCGA-FI-A2D5	UCEC	TCGA	DSGKST	DEG_SCF_TRCP1_1	0.1111
p.N625T	DO41331	UCEC	ICGC	DSGKST	DEG_SCF_TRCP1_1	0.1111
p.G635C	DO228948	LICA	ICGC	DSGKST	DEG_SCF_TRCP1_1	0.76
p.D630G	DO45299	LIRI	ICGC	DSGKST	DEG_SCF_TRCP1_1	0.25
p.P624S	ACH-001566	Skin Cancer	CCLE	DSGKST	DEG_SCF_TRCP1_1	0.0833
p.M646V	ACH-002019	Cervical Cancer	CCLE	DSGKST	DEG_SCF_TRCP1_1	0.1111
p.P639S	HCT-15	large_intestine	COSMIC	DSGKST	DEG_SCF_TRCP1_1	0.3056
p.D629E	CW-2	large_intestine	COSMIC	DSGKST	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13480	GRB2-associated-binding protein 1	DEG_SCF_TRCP1_1	633:638	DSGKST	BTRC	0.9988	More...
Q9NW68	BSD domain-containing protein 1	DEG_SCF_TRCP1_1	373:378	DSGKST	BTRC	0.9905	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons