DegronMD

Uniprot ID: Q9NW68

Source protein: BSD domain-containing protein 1

Source gene: BSDC1

Class: DEG_SCF_TRCP1_1

Location: 373:378

E3 ligase: BTRC

DEGRON score: 0.9905

ASA_SCORE: 88.6833

COIL: 0.9432

CONS_SCORE: 0.2698

DSS_SCORE: 0.6394

HELIX: 0.0237

FCONS_SCORE: 0.9821

RIG_SCORE: 0.573

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P363L	TCGA-18-3410	LUSC	TCGA	DSGKST	DEG_SCF_TRCP1_1	0.0556
p.E372K	TCGA-22-1016	LUSC	TCGA	DSGKST	DEG_SCF_TRCP1_1	0.75
p.D381H	TCGA-29-2429	OV	TCGA	DSGKST	DEG_SCF_TRCP1_1	0.25
p.L382I	TCGA-86-8668	LUAD	TCGA	DSGKST	DEG_SCF_TRCP1_1	0.2222
p.E386Q	TCGA-BA-5152	HNSC	TCGA	DSGKST	DEG_SCF_TRCP1_1	0.1111
p.E386Q	TCGA-OL-A97C	BRCA	TCGA	DSGKST	DEG_SCF_TRCP1_1	0.1111
p.A378V	TCGA-DU-6392	LGG	TCGA	DSGKST	DEG_SCF_TRCP1_1	0.6936
p.E372Q	TCGA-EA-A43B	CESC	TCGA	DSGKST	DEG_SCF_TRCP1_1	0.75
p.E372Q	TCGA-ZF-A9R7	BLCA	TCGA	DSGKST	DEG_SCF_TRCP1_1	0.75
p.R383W	TCGA-SJ-A6ZI	UCEC	TCGA	DSGKST	DEG_SCF_TRCP1_1	0.1944
p.E369Q	DO219640	BRCA	ICGC	DSGKST	DEG_SCF_TRCP1_1	0.2222
p.E369Q	DO14393	HNSC	ICGC	DSGKST	DEG_SCF_TRCP1_1	0.2222
p.T363S	DO232028	LICA	ICGC	DSGKST	DEG_SCF_TRCP1_1	0.0556
p.R366W	DO219784	UCEC	ICGC	DSGKST	DEG_SCF_TRCP1_1	0.1389
p.K384N	DO41758	UCEC	ICGC	DSGKST	DEG_SCF_TRCP1_1	0.2778
p.R370K	SIDM00193	Colorectal Carcinoma	GDSC	DSGKST	DEG_SCF_TRCP1_1	0.25
p.R370K	SNU-81	large_intestine	COSMIC	DSGKST	DEG_SCF_TRCP1_1	0.25
p.D381N	SIDM00767	Small Cell Lung Carcinoma	GDSC	DSGKST	DEG_SCF_TRCP1_1	0.25
p.D381N	NCI-H187	lung	COSMIC	DSGKST	DEG_SCF_TRCP1_1	0.25
p.T378K	ACH-000137	Brain Cancer	CCLE	DSGKST	DEG_SCF_TRCP1_1	0.8417
p.T378K	8-MG-BA	central_nervous_system	COSMIC	DSGKST	DEG_SCF_TRCP1_1	0.8417
p.D364N	ACH-001136	Lung Cancer	CCLE	DSGKST	DEG_SCF_TRCP1_1	0.0833
p.D364N	NCI-H187	lung	COSMIC	DSGKST	DEG_SCF_TRCP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13480	GRB2-associated-binding protein 1	DEG_SCF_TRCP1_1	633:638	DSGKST	BTRC	0.9988	More...
Q9NW68	BSD domain-containing protein 1	DEG_SCF_TRCP1_1	373:378	DSGKST	BTRC	0.9905	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons