DegronMD - Q96DV4(MRPL38)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D371G	TCGA-AX-A1CE	UCEC	TCGA	HRQPLRYLD	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.2222
p.R356C	TCGA-AX-A1CE	UCEC	TCGA	HRQPLRYLD	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.25
p.R356C	TCGA-AX-A1CE	UCEC	TCGA	PPPY	ITCH	347:350	Mutation rewiring degron network	0.1667
p.R356C	TCGA-B5-A11E	UCEC	TCGA	HRQPLRYLD	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.25
p.R356C	TCGA-B5-A11E	UCEC	TCGA	PPPY	ITCH	347:350	Mutation rewiring degron network	0.1667
p.R338W	TCGA-B5-A3FC	UCEC	TCGA	PPPY	ITCH	347:350	Mutation rewiring degron network	0.0833
p.R360Q	TCGA-BR-8591	STAD	TCGA	HRQPLRYLD	DEG_APCC_DBOX_1	359:367	Mutation altering degron motif	0.7329
p.P348S	TCGA-DA-A95Z	SKCM	TCGA	PPPY	ITCH	347:350	Mutation altering degron motif	0.6752
p.V345L	TCGA-E7-A5KE	BLCA	TCGA	PPPY	ITCH	347:350	Mutation rewiring degron network	0.2778
p.R346W	TCGA-F1-6177	STAD	TCGA	PPPY	ITCH	347:350	Mutation rewiring degron network	0.3056
p.L366M	TCGA-SJ-A6ZI	UCEC	TCGA	HRQPLRYLD	DEG_APCC_DBOX_1	359:367	Mutation altering degron motif	0.5999
p.S372R	TCGA-WB-A822	PCPG	TCGA	HRQPLRYLD	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.1944
p.E343K	TCGA-WY-A859	LGG	TCGA	PPPY	ITCH	347:350	Mutation rewiring degron network	0.2222
p.R364C	SIDM02026	Colorectal Carcinoma	GDSC	HRQPLRYLD	DEG_APCC_DBOX_1	359:367	Mutation altering degron motif	0.719
p.R346Q	SIDM01164	Glioma	GDSC	PPPY	ITCH	347:350	Mutation rewiring degron network	0.3056
p.R346Q	ACH-000883	Brain Cancer	CCLE	PPPY	ITCH	347:350	Mutation rewiring degron network	0.3056
p.R346Q	SW1783	central nervous system	COSMIC	PPPY	ITCH	347:350	Mutation rewiring degron network	0.3056
p.P375T	ACH-002120	Skin Cancer	CCLE	HRQPLRYLD	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.1111

Kaplan plot for MRPL38 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MRPL38

UniProt ID: Q96DV4

Entrez ID: 64978

Protein name: 39S ribosomal protein L38, mitochondrial (L38mt) (MRP-L38) (Mitochondrial large ribosomal subunit protein mL38)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for MRPL38 in