DegronMD

Uniprot ID: Q96DV4

Source protein: 39S ribosomal protein L38, mitochondrial

Source gene: MRPL38

Class: DEG_APCC_DBOX_1

Location: 359:367

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9437

ASA_SCORE: 85.1

COIL: 0.71

CONS_SCORE: 0.4398

DSS_SCORE: 0.5117

HELIX: 0.2614

FCONS_SCORE: 1.0702

RIG_SCORE: 0.759

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D371G	TCGA-AX-A1CE	UCEC	TCGA	HRQPLRYLD	DEG_APCC_DBOX_1	0.2222
p.R356C	TCGA-AX-A1CE	UCEC	TCGA	HRQPLRYLD	DEG_APCC_DBOX_1	0.25
p.R356C	TCGA-B5-A11E	UCEC	TCGA	HRQPLRYLD	DEG_APCC_DBOX_1	0.25
p.R360Q	TCGA-BR-8591	STAD	TCGA	HRQPLRYLD	DEG_APCC_DBOX_1	0.7329
p.L366M	TCGA-SJ-A6ZI	UCEC	TCGA	HRQPLRYLD	DEG_APCC_DBOX_1	0.5999
p.S372R	TCGA-WB-A822	PCPG	TCGA	HRQPLRYLD	DEG_APCC_DBOX_1	0.1944
p.R364C	SIDM02026	Colorectal Carcinoma	GDSC	HRQPLRYLD	DEG_APCC_DBOX_1	0.719
p.P375T	ACH-002120	Skin Cancer	CCLE	HRQPLRYLD	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96DV4	39S ribosomal protein L38, mitochondrial	DEG_APCC_DBOX_1	359:367	HRQPLRYLD	APC,CDC20,FZR1	0.9437	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons