DegronMD - Q14112(NID2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1357Q	TCGA-2W-A8YY	CESC	TCGA	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation altering degron motif	0.7329
p.R1357Q	TCGA-AP-A1E0	UCEC	TCGA	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation altering degron motif	0.7329
p.R1357Q	TCGA-BF-A3DM	SKCM	TCGA	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation altering degron motif	0.7329
p.R1357Q	TCGA-EE-A183	SKCM	TCGA	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation altering degron motif	0.7329
p.R1357Q	TCGA-EI-6917	READ	TCGA	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation altering degron motif	0.7329
p.R1357Q	DO223732	CESC	ICGC	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation altering degron motif	0.7329
p.R1357Q	DO36881	READ	ICGC	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation altering degron motif	0.7329
p.R1357Q	DO37715	SKCM	ICGC	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation altering degron motif	0.7329
p.R1357Q	DO48667	SKCM	ICGC	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation altering degron motif	0.7329
p.R1357Q	DO43154	UCEC	ICGC	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation altering degron motif	0.7329
p.E35K	TCGA-37-A5EM	LUSC	TCGA	LFPHGE	LIG_APCC_ABBA_1	36:41	Mutation rewiring degron network	0.3056
p.E35K	DO223719	LUSC	ICGC	LFPHGE	LIG_APCC_ABBA_1	36:41	Mutation rewiring degron network	0.3056
p.E35K	SIDM01611	Endometrial Carcinoma	GDSC	LFPHGE	LIG_APCC_ABBA_1	36:41	Mutation rewiring degron network	0.3056
p.E35K	ACH-000996	Endometrial/Uterine Cancer	CCLE	LFPHGE	LIG_APCC_ABBA_1	36:41	Mutation rewiring degron network	0.3056
p.P1354L	TCGA-43-3394	LUSC	TCGA	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation rewiring degron network	0.2778
p.P1354L	DO26596	LUSC	ICGC	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation rewiring degron network	0.2778
p.W43S	TCGA-55-8092	LUAD	TCGA	LFPHGE	LIG_APCC_ABBA_1	36:41	Mutation rewiring degron network	0.2778
p.W43S	DO26220	LUAD	ICGC	LFPHGE	LIG_APCC_ABBA_1	36:41	Mutation rewiring degron network	0.2778
p.P422H	TCGA-66-2787	LUSC	TCGA	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation altering degron motif	0.7694
p.G44E	TCGA-69-7974	LUAD	TCGA	LFPHGE	LIG_APCC_ABBA_1	36:41	Mutation rewiring degron network	0.25
p.G44E	DO23850	LUAD	ICGC	LFPHGE	LIG_APCC_ABBA_1	36:41	Mutation rewiring degron network	0.25
p.P1354T	TCGA-86-6851	LUAD	TCGA	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation rewiring degron network	0.2778
p.P1354T	DO23798	LUAD	ICGC	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation rewiring degron network	0.2778
p.G40R	TCGA-A6-5661	COAD	TCGA	LFPHGE	LIG_APCC_ABBA_1	36:41	Mutation altering degron motif	0.6457
p.G40R	DO8634	COAD	ICGC	LFPHGE	LIG_APCC_ABBA_1	36:41	Mutation altering degron motif	0.6457
p.A1365T	TCGA-AK-3444	KIRC	TCGA	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation rewiring degron network	0.3056
p.A1365T	SIDM00259	Neuroblastoma	GDSC	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation rewiring degron network	0.3056
p.A1365T	ACH-002278	Neuroblastoma	CCLE	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation rewiring degron network	0.3056
p.A1365T	NB10	autonomic ganglia	COSMIC	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation rewiring degron network	0.3056
p.R27W	TCGA-AP-A1DR	UCEC	TCGA	LFPHGE	LIG_APCC_ABBA_1	36:41	Mutation rewiring degron network	0.0833
p.R27W	DO43747	UCEC	ICGC	LFPHGE	LIG_APCC_ABBA_1	36:41	Mutation rewiring degron network	0.0833
p.E416K	TCGA-AX-A0J0	UCEC	TCGA	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.2222
p.E416K	TCGA-AX-A0J0	UCEC	TCGA	PPPY	ITCH	411:414	Mutation rewiring degron network	0.2778
p.E416K	TCGA-EI-6917	READ	TCGA	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.2222
p.E416K	TCGA-EI-6917	READ	TCGA	PPPY	ITCH	411:414	Mutation rewiring degron network	0.2778
p.E416K	TCGA-EO-A22X	UCEC	TCGA	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.2222
p.E416K	TCGA-EO-A22X	UCEC	TCGA	PPPY	ITCH	411:414	Mutation rewiring degron network	0.2778
p.E416K	DO36881	READ	ICGC	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.2222
p.E416K	DO36881	READ	ICGC	PPPY	ITCH	411:414	Mutation rewiring degron network	0.2778
p.E416K	DO43907	UCEC	ICGC	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.2222
p.E416K	DO43907	UCEC	ICGC	PPPY	ITCH	411:414	Mutation rewiring degron network	0.2778
p.E416K	DO41133	UCEC	ICGC	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.2222
p.E416K	DO41133	UCEC	ICGC	PPPY	ITCH	411:414	Mutation rewiring degron network	0.2778
p.E416K	SIDM01768	Melanoma	GDSC	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.2222
p.E416K	SIDM01768	Melanoma	GDSC	PPPY	ITCH	411:414	Mutation rewiring degron network	0.2778
p.E416K	ACH-000899	Skin Cancer	CCLE	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.2222
p.E416K	ACH-000899	Skin Cancer	CCLE	PPPY	ITCH	411:414	Mutation rewiring degron network	0.2778
p.D402Y	TCGA-AX-A0J0	UCEC	TCGA	PPPY	ITCH	411:414	Mutation rewiring degron network	0.0833
p.D402Y	DO41133	UCEC	ICGC	PPPY	ITCH	411:414	Mutation rewiring degron network	0.0833
p.E35G	TCGA-AX-A2HD	UCEC	TCGA	LFPHGE	LIG_APCC_ABBA_1	36:41	Mutation rewiring degron network	0.3056
p.E35G	DO42608	UCEC	ICGC	LFPHGE	LIG_APCC_ABBA_1	36:41	Mutation rewiring degron network	0.3056
p.P38S	TCGA-BR-4201	STAD	TCGA	LFPHGE	LIG_APCC_ABBA_1	36:41	Mutation altering degron motif	0.6752
p.P38S	DO38707	STAD	ICGC	LFPHGE	LIG_APCC_ABBA_1	36:41	Mutation altering degron motif	0.6752
p.F37L	TCGA-BS-A0UJ	UCEC	TCGA	LFPHGE	LIG_APCC_ABBA_1	36:41	Mutation altering degron motif	0.587
p.F37L	DO42745	UCEC	ICGC	LFPHGE	LIG_APCC_ABBA_1	36:41	Mutation altering degron motif	0.587
p.P422T	TCGA-CV-6933	HNSC	TCGA	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation altering degron motif	0.7031
p.P422T	DO14164	HNSC	ICGC	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation altering degron motif	0.7031
p.P430S	TCGA-D3-A2JF	SKCM	TCGA	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.1944
p.G1362V	TCGA-D3-A3CE	SKCM	TCGA	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation altering degron motif	0.6421
p.G1362V	DO37405	SKCM	ICGC	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation altering degron motif	0.6421
p.G418E	TCGA-D3-A51T	SKCM	TCGA	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.2778
p.G418E	TCGA-D3-A51T	SKCM	TCGA	PPPY	ITCH	411:414	Mutation rewiring degron network	0.2222
p.G426V	TCGA-DA-A1IB	SKCM	TCGA	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.3056
p.P415L	TCGA-EE-A29D	SKCM	TCGA	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.1944
p.P415L	TCGA-EE-A29D	SKCM	TCGA	PPPY	ITCH	411:414	Mutation rewiring degron network	0.3056
p.P415L	DO38123	SKCM	ICGC	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.1944
p.P415L	DO38123	SKCM	ICGC	PPPY	ITCH	411:414	Mutation rewiring degron network	0.3056
p.P424S	TCGA-EE-A2M5	SKCM	TCGA	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation altering degron motif	0.5641
p.P424S	DO222423	MELA	ICGC	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation altering degron motif	0.5641
p.P424S	DO37425	SKCM	ICGC	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation altering degron motif	0.5641
p.N417K	TCGA-FD-A3SS	BLCA	TCGA	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.25
p.N417K	TCGA-FD-A3SS	BLCA	TCGA	PPPY	ITCH	411:414	Mutation rewiring degron network	0.25
p.N417K	DO737	BLCA	ICGC	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.25
p.N417K	DO737	BLCA	ICGC	PPPY	ITCH	411:414	Mutation rewiring degron network	0.25
p.S431L	TCGA-FW-A3R5	SKCM	TCGA	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.1667
p.S431L	ACH-001973	Metastasis	CCLE	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.1667
p.G426A	TCGA-L9-A7SV	LUAD	TCGA	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.3056
p.T410I	TCGA-QM-A5NM	UCS	TCGA	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.0556
p.T410I	TCGA-QM-A5NM	UCS	TCGA	PPPY	ITCH	411:414	Mutation rewiring degron network	0.3056
p.N417S	TCGA-QU-A6IM	PRAD	TCGA	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.25
p.N417S	TCGA-QU-A6IM	PRAD	TCGA	PPPY	ITCH	411:414	Mutation rewiring degron network	0.25
p.N417S	DO49852	PRAD	ICGC	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.25
p.N417S	DO49852	PRAD	ICGC	PPPY	ITCH	411:414	Mutation rewiring degron network	0.25
p.Y1352H	TCGA-VQ-A8PT	STAD	TCGA	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation rewiring degron network	0.2222
p.Y1352H	DO51776	STAD	ICGC	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation rewiring degron network	0.2222
p.A28P	TCGA-ZS-A9CG	LIHC	TCGA	LFPHGE	LIG_APCC_ABBA_1	36:41	Mutation rewiring degron network	0.1111
p.A28P	DO52336	LIHC	ICGC	LFPHGE	LIG_APCC_ABBA_1	36:41	Mutation rewiring degron network	0.1111
p.G1362R	DO218828	BRCA	ICGC	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation altering degron motif	0.6457
p.G1362R	DO225261	BRCA	ICGC	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation altering degron motif	0.6457
p.G1362R	SIDM01218	Other Solid Cancers	GDSC	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation altering degron motif	0.6457
p.G1362R	JEG-3	placenta	COSMIC	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation altering degron motif	0.6457
p.T426M	DO50403	ESAD	ICGC	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.3056
p.T426M	DO41235	UCEC	ICGC	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.3056
p.A29T	DO234234	ESAD	ICGC	LFPHGE	LIG_APCC_ABBA_1	36:41	Mutation rewiring degron network	0.1389
p.A29T	DO234282	ESAD	ICGC	LFPHGE	LIG_APCC_ABBA_1	36:41	Mutation rewiring degron network	0.1389
p.R37M	DO234437	ESAD	ICGC	LFPHGE	LIG_APCC_ABBA_1	36:41	Mutation altering degron motif	0.8632
p.Q49K	DO233767	GACA	ICGC	LFPHGE	LIG_APCC_ABBA_1	36:41	Mutation rewiring degron network	0.1111
p.Y1361H	DO233903	GACA	ICGC	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation altering degron motif	0.6118
p.Y410H	DO14662	HNSC	ICGC	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.0556
p.Y410H	DO14662	HNSC	ICGC	PPPY	ITCH	411:414	Mutation rewiring degron network	0.3056
p.T26I	DO49803	KIRP	ICGC	LFPHGE	LIG_APCC_ABBA_1	36:41	Mutation rewiring degron network	0.0556
p.P404H	DO229025	LICA	ICGC	PPPY	ITCH	411:414	Mutation rewiring degron network	0.1389
p.P1371T	DO229045	LICA	ICGC	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation rewiring degron network	0.1389
p.Y427C	DO45093	LIRI	ICGC	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.2778
p.P51Q	DO23798	LUAD	ICGC	LFPHGE	LIG_APCC_ABBA_1	36:41	Mutation rewiring degron network	0.0556
p.T26S	DO45491	LUSC	ICGC	LFPHGE	LIG_APCC_ABBA_1	36:41	Mutation rewiring degron network	0.0556
p.T409M	DO228138	PBCA	ICGC	PPPY	ITCH	411:414	Mutation rewiring degron network	0.2778
p.T409M	DO43049	UCEC	ICGC	PPPY	ITCH	411:414	Mutation rewiring degron network	0.2778
p.T409M	DO41847	UCEC	ICGC	PPPY	ITCH	411:414	Mutation rewiring degron network	0.2778
p.E41D	DO228792	PRAD	ICGC	LFPHGE	LIG_APCC_ABBA_1	36:41	Mutation altering degron motif	0.5647
p.E38K	DO229446	SKCA	ICGC	LFPHGE	LIG_APCC_ABBA_1	36:41	Mutation altering degron motif	0.7022
p.P36L	DO229502	SKCA	ICGC	LFPHGE	LIG_APCC_ABBA_1	36:41	Mutation altering degron motif	0.7582
p.S407F	SIDM01062	Breast Carcinoma	GDSC	PPPY	ITCH	411:414	Mutation rewiring degron network	0.2222
p.S407F	ACH-000643	Breast Cancer	CCLE	PPPY	ITCH	411:414	Mutation rewiring degron network	0.2222
p.S407F	HDQ-P1	breast	COSMIC	PPPY	ITCH	411:414	Mutation rewiring degron network	0.2222
p.H1359Q	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation altering degron motif	0.647
p.H1359Q	ACH-000647	Esophageal Cancer	CCLE	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation altering degron motif	0.647
p.H1359Q	TE-1	oesophagus	COSMIC	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation altering degron motif	0.647
p.R1357P	SIDM00966	Ovarian Carcinoma	GDSC	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation altering degron motif	0.7512
p.R1357P	ACH-002182	Ovarian Cancer	CCLE	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation altering degron motif	0.7512
p.R1357P	OVCA433	ovary	COSMIC	QRSHLYGIT	DEG_APCC_DBOX_1	1356:1364	Mutation altering degron motif	0.7512
p.P415T	SIDM00730	Small Cell Lung Carcinoma	GDSC	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.1944
p.P415T	SIDM00730	Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	411:414	Mutation rewiring degron network	0.3056
p.P415T	ACH-000610	Lung Cancer	CCLE	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.1944
p.P415T	ACH-000610	Lung Cancer	CCLE	PPPY	ITCH	411:414	Mutation rewiring degron network	0.3056
p.P415T	NCI-H2227	lung	COSMIC	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.1944
p.P415T	NCI-H2227	lung	COSMIC	PPPY	ITCH	411:414	Mutation rewiring degron network	0.3056
p.D425N	SIDM00006	Other Solid Cancers	GDSC	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation altering degron motif	0.6932
p.D425N	ACH-001552	Skin Cancer	CCLE	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation altering degron motif	0.6932
p.D425N	MCC26	skin	COSMIC	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation altering degron motif	0.6932
p.P424T	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation altering degron motif	0.5919
p.P424T	ACH-000888	Lung Cancer	CCLE	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation altering degron motif	0.5919
p.P424T	NCI-H1793	lung	COSMIC	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation altering degron motif	0.5919
p.S419N	SIDM01518	Oral Cavity Carcinoma	GDSC	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.3056
p.S419N	SIDM01518	Oral Cavity Carcinoma	GDSC	PPPY	ITCH	411:414	Mutation rewiring degron network	0.1944
p.S419N	ACH-000771	Head and Neck Cancer	CCLE	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.3056
p.S419N	ACH-000771	Head and Neck Cancer	CCLE	PPPY	ITCH	411:414	Mutation rewiring degron network	0.1944
p.E416V	ACH-002508	Skin Cancer	CCLE	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.2222
p.E416V	ACH-002508	Skin Cancer	CCLE	PPPY	ITCH	411:414	Mutation rewiring degron network	0.2778
p.D431N	NCI-H378	lung	COSMIC	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.1667
p.R424W	JHU-011	upper aerodigestive tract	COSMIC	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation altering degron motif	0.8634
p.S425R	H513	pleura	COSMIC	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation altering degron motif	0.7427
p.N409K	BT-20	breast	COSMIC	PPPY	ITCH	411:414	Mutation rewiring degron network	0.2778
p.R405L	NCI-H345	lung	COSMIC	PPPY	ITCH	411:414	Mutation rewiring degron network	0.1667
p.R405H	NCI-H1155	lung	COSMIC	PPPY	ITCH	411:414	Mutation rewiring degron network	0.1667
p.P416R	CML-T1	haematopoietic and lymphoid tissue	COSMIC	IQPYPD	LIG_APCC_ABBA_1	420:425	Mutation rewiring degron network	0.2222
p.P416R	CML-T1	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	411:414	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NID2

UniProt ID: Q14112

Entrez ID: 22795

Protein name: Nidogen-2 (NID-2) (Osteonidogen)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NID2 in