DegronMD

Uniprot ID: Q14112

Source protein: Nidogen-2

Source gene: NID2

Class: LIG_APCC_ABBA_1

Location: 420:425

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9924

ASA_SCORE: 80.75

COIL: 0.854

CONS_SCORE: 0.2691

DSS_SCORE: 0.7459

HELIX: 0.0248

FCONS_SCORE: 1.0646

RIG_SCORE: 0.5645

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P422H	TCGA-66-2787	LUSC	TCGA	IQPYPD	LIG_APCC_ABBA_1	0.7694
p.E416K	TCGA-AX-A0J0	UCEC	TCGA	IQPYPD	LIG_APCC_ABBA_1	0.2222
p.E416K	TCGA-EI-6917	READ	TCGA	IQPYPD	LIG_APCC_ABBA_1	0.2222
p.E416K	TCGA-EO-A22X	UCEC	TCGA	IQPYPD	LIG_APCC_ABBA_1	0.2222
p.E416K	DO36881	READ	ICGC	IQPYPD	LIG_APCC_ABBA_1	0.2222
p.E416K	DO43907	UCEC	ICGC	IQPYPD	LIG_APCC_ABBA_1	0.2222
p.E416K	DO41133	UCEC	ICGC	IQPYPD	LIG_APCC_ABBA_1	0.2222
p.E416K	SIDM01768	Melanoma	GDSC	IQPYPD	LIG_APCC_ABBA_1	0.2222
p.E416K	ACH-000899	Skin Cancer	CCLE	IQPYPD	LIG_APCC_ABBA_1	0.2222
p.P422T	TCGA-CV-6933	HNSC	TCGA	IQPYPD	LIG_APCC_ABBA_1	0.7031
p.P422T	DO14164	HNSC	ICGC	IQPYPD	LIG_APCC_ABBA_1	0.7031
p.P430S	TCGA-D3-A2JF	SKCM	TCGA	IQPYPD	LIG_APCC_ABBA_1	0.1944
p.G418E	TCGA-D3-A51T	SKCM	TCGA	IQPYPD	LIG_APCC_ABBA_1	0.2778
p.G426V	TCGA-DA-A1IB	SKCM	TCGA	IQPYPD	LIG_APCC_ABBA_1	0.3056
p.P415L	TCGA-EE-A29D	SKCM	TCGA	IQPYPD	LIG_APCC_ABBA_1	0.1944
p.P415L	DO38123	SKCM	ICGC	IQPYPD	LIG_APCC_ABBA_1	0.1944
p.P424S	TCGA-EE-A2M5	SKCM	TCGA	IQPYPD	LIG_APCC_ABBA_1	0.5641
p.P424S	DO222423	MELA	ICGC	IQPYPD	LIG_APCC_ABBA_1	0.5641
p.P424S	DO37425	SKCM	ICGC	IQPYPD	LIG_APCC_ABBA_1	0.5641
p.N417K	TCGA-FD-A3SS	BLCA	TCGA	IQPYPD	LIG_APCC_ABBA_1	0.25
p.N417K	DO737	BLCA	ICGC	IQPYPD	LIG_APCC_ABBA_1	0.25
p.S431L	TCGA-FW-A3R5	SKCM	TCGA	IQPYPD	LIG_APCC_ABBA_1	0.1667
p.S431L	ACH-001973	Metastasis	CCLE	IQPYPD	LIG_APCC_ABBA_1	0.1667
p.G426A	TCGA-L9-A7SV	LUAD	TCGA	IQPYPD	LIG_APCC_ABBA_1	0.3056
p.T410I	TCGA-QM-A5NM	UCS	TCGA	IQPYPD	LIG_APCC_ABBA_1	0.0556
p.N417S	TCGA-QU-A6IM	PRAD	TCGA	IQPYPD	LIG_APCC_ABBA_1	0.25
p.N417S	DO49852	PRAD	ICGC	IQPYPD	LIG_APCC_ABBA_1	0.25
p.T426M	DO50403	ESAD	ICGC	IQPYPD	LIG_APCC_ABBA_1	0.3056
p.T426M	DO41235	UCEC	ICGC	IQPYPD	LIG_APCC_ABBA_1	0.3056
p.Y410H	DO14662	HNSC	ICGC	IQPYPD	LIG_APCC_ABBA_1	0.0556
p.Y427C	DO45093	LIRI	ICGC	IQPYPD	LIG_APCC_ABBA_1	0.2778
p.P415T	SIDM00730	Small Cell Lung Carcinoma	GDSC	IQPYPD	LIG_APCC_ABBA_1	0.1944
p.P415T	ACH-000610	Lung Cancer	CCLE	IQPYPD	LIG_APCC_ABBA_1	0.1944
p.P415T	NCI-H2227	lung	COSMIC	IQPYPD	LIG_APCC_ABBA_1	0.1944
p.D425N	SIDM00006	Other Solid Cancers	GDSC	IQPYPD	LIG_APCC_ABBA_1	0.6932
p.D425N	ACH-001552	Skin Cancer	CCLE	IQPYPD	LIG_APCC_ABBA_1	0.6932
p.D425N	MCC26	skin	COSMIC	IQPYPD	LIG_APCC_ABBA_1	0.6932
p.P424T	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	IQPYPD	LIG_APCC_ABBA_1	0.5919
p.P424T	ACH-000888	Lung Cancer	CCLE	IQPYPD	LIG_APCC_ABBA_1	0.5919
p.P424T	NCI-H1793	lung	COSMIC	IQPYPD	LIG_APCC_ABBA_1	0.5919
p.S419N	SIDM01518	Oral Cavity Carcinoma	GDSC	IQPYPD	LIG_APCC_ABBA_1	0.3056
p.S419N	ACH-000771	Head and Neck Cancer	CCLE	IQPYPD	LIG_APCC_ABBA_1	0.3056
p.E416V	ACH-002508	Skin Cancer	CCLE	IQPYPD	LIG_APCC_ABBA_1	0.2222
p.D431N	NCI-H378	lung	COSMIC	IQPYPD	LIG_APCC_ABBA_1	0.1667
p.R424W	JHU-011	upper_aerodigestive_tract	COSMIC	IQPYPD	LIG_APCC_ABBA_1	0.8634
p.S425R	H513	pleura	COSMIC	IQPYPD	LIG_APCC_ABBA_1	0.7427
p.P416R	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	IQPYPD	LIG_APCC_ABBA_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IQPYPD

Degron related mutations and impact score

Drug responses associated with NID2 mutations

All proteins holding degron of IQPYPD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14112	Nidogen-2	LIG_APCC_ABBA_1	420:425	IQPYPD	APC,CDC20,FZR1	0.9924	More...