DegronMD

Uniprot ID: Q14112

Source protein: Nidogen-2

Source gene: NID2

Class: LIG_APCC_ABBA_1

Location: 36:41

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5776

ASA_SCORE: 52.15

COIL: 0.7508

CONS_SCORE: 0.4592

DSS_SCORE: 0.2845

HELIX: 0.1703

FCONS_SCORE: 1.232

RIG_SCORE: 0.7138

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E35K	TCGA-37-A5EM	LUSC	TCGA	LFPHGE	LIG_APCC_ABBA_1	0.3056
p.E35K	DO223719	LUSC	ICGC	LFPHGE	LIG_APCC_ABBA_1	0.3056
p.E35K	SIDM01611	Endometrial Carcinoma	GDSC	LFPHGE	LIG_APCC_ABBA_1	0.3056
p.E35K	ACH-000996	Endometrial/Uterine Cancer	CCLE	LFPHGE	LIG_APCC_ABBA_1	0.3056
p.W43S	TCGA-55-8092	LUAD	TCGA	LFPHGE	LIG_APCC_ABBA_1	0.2778
p.W43S	DO26220	LUAD	ICGC	LFPHGE	LIG_APCC_ABBA_1	0.2778
p.G44E	TCGA-69-7974	LUAD	TCGA	LFPHGE	LIG_APCC_ABBA_1	0.25
p.G44E	DO23850	LUAD	ICGC	LFPHGE	LIG_APCC_ABBA_1	0.25
p.G40R	TCGA-A6-5661	COAD	TCGA	LFPHGE	LIG_APCC_ABBA_1	0.6457
p.G40R	DO8634	COAD	ICGC	LFPHGE	LIG_APCC_ABBA_1	0.6457
p.R27W	TCGA-AP-A1DR	UCEC	TCGA	LFPHGE	LIG_APCC_ABBA_1	0.0833
p.R27W	DO43747	UCEC	ICGC	LFPHGE	LIG_APCC_ABBA_1	0.0833
p.E35G	TCGA-AX-A2HD	UCEC	TCGA	LFPHGE	LIG_APCC_ABBA_1	0.3056
p.E35G	DO42608	UCEC	ICGC	LFPHGE	LIG_APCC_ABBA_1	0.3056
p.P38S	TCGA-BR-4201	STAD	TCGA	LFPHGE	LIG_APCC_ABBA_1	0.6752
p.P38S	DO38707	STAD	ICGC	LFPHGE	LIG_APCC_ABBA_1	0.6752
p.F37L	TCGA-BS-A0UJ	UCEC	TCGA	LFPHGE	LIG_APCC_ABBA_1	0.587
p.F37L	DO42745	UCEC	ICGC	LFPHGE	LIG_APCC_ABBA_1	0.587
p.A28P	TCGA-ZS-A9CG	LIHC	TCGA	LFPHGE	LIG_APCC_ABBA_1	0.1111
p.A28P	DO52336	LIHC	ICGC	LFPHGE	LIG_APCC_ABBA_1	0.1111
p.A29T	DO234234	ESAD	ICGC	LFPHGE	LIG_APCC_ABBA_1	0.1389
p.A29T	DO234282	ESAD	ICGC	LFPHGE	LIG_APCC_ABBA_1	0.1389
p.R37M	DO234437	ESAD	ICGC	LFPHGE	LIG_APCC_ABBA_1	0.8632
p.Q49K	DO233767	GACA	ICGC	LFPHGE	LIG_APCC_ABBA_1	0.1111
p.T26I	DO49803	KIRP	ICGC	LFPHGE	LIG_APCC_ABBA_1	0.0556
p.P51Q	DO23798	LUAD	ICGC	LFPHGE	LIG_APCC_ABBA_1	0.0556
p.T26S	DO45491	LUSC	ICGC	LFPHGE	LIG_APCC_ABBA_1	0.0556
p.E41D	DO228792	PRAD	ICGC	LFPHGE	LIG_APCC_ABBA_1	0.5647
p.E38K	DO229446	SKCA	ICGC	LFPHGE	LIG_APCC_ABBA_1	0.7022
p.P36L	DO229502	SKCA	ICGC	LFPHGE	LIG_APCC_ABBA_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14112	Nidogen-2	LIG_APCC_ABBA_1	36:41	LFPHGE	APC,CDC20,FZR1	0.5776	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LFPHGE

Degron related mutations and impact score

Drug responses associated with NID2 mutations

All proteins holding degron of LFPHGE