DegronMD

Uniprot ID: Q14112

Source protein: Nidogen-2

Source gene: NID2

Class: DEG_APCC_DBOX_1

Location: 1356:1364

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6989

ASA_SCORE: 46.0889

COIL: 0.5461

CONS_SCORE: 0.5561

DSS_SCORE: 0.2259

HELIX: 0.0529

FCONS_SCORE: 1.3351

RIG_SCORE: 0.7965

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1357Q	TCGA-2W-A8YY	CESC	TCGA	QRSHLYGIT	DEG_APCC_DBOX_1	0.7329
p.R1357Q	TCGA-AP-A1E0	UCEC	TCGA	QRSHLYGIT	DEG_APCC_DBOX_1	0.7329
p.R1357Q	TCGA-BF-A3DM	SKCM	TCGA	QRSHLYGIT	DEG_APCC_DBOX_1	0.7329
p.R1357Q	TCGA-EE-A183	SKCM	TCGA	QRSHLYGIT	DEG_APCC_DBOX_1	0.7329
p.R1357Q	TCGA-EI-6917	READ	TCGA	QRSHLYGIT	DEG_APCC_DBOX_1	0.7329
p.R1357Q	DO223732	CESC	ICGC	QRSHLYGIT	DEG_APCC_DBOX_1	0.7329
p.R1357Q	DO36881	READ	ICGC	QRSHLYGIT	DEG_APCC_DBOX_1	0.7329
p.R1357Q	DO37715	SKCM	ICGC	QRSHLYGIT	DEG_APCC_DBOX_1	0.7329
p.R1357Q	DO48667	SKCM	ICGC	QRSHLYGIT	DEG_APCC_DBOX_1	0.7329
p.R1357Q	DO43154	UCEC	ICGC	QRSHLYGIT	DEG_APCC_DBOX_1	0.7329
p.P1354L	TCGA-43-3394	LUSC	TCGA	QRSHLYGIT	DEG_APCC_DBOX_1	0.2778
p.P1354L	DO26596	LUSC	ICGC	QRSHLYGIT	DEG_APCC_DBOX_1	0.2778
p.P1354T	TCGA-86-6851	LUAD	TCGA	QRSHLYGIT	DEG_APCC_DBOX_1	0.2778
p.P1354T	DO23798	LUAD	ICGC	QRSHLYGIT	DEG_APCC_DBOX_1	0.2778
p.A1365T	TCGA-AK-3444	KIRC	TCGA	QRSHLYGIT	DEG_APCC_DBOX_1	0.3056
p.A1365T	SIDM00259	Neuroblastoma	GDSC	QRSHLYGIT	DEG_APCC_DBOX_1	0.3056
p.A1365T	ACH-002278	Neuroblastoma	CCLE	QRSHLYGIT	DEG_APCC_DBOX_1	0.3056
p.A1365T	NB10	autonomic_ganglia	COSMIC	QRSHLYGIT	DEG_APCC_DBOX_1	0.3056
p.G1362V	TCGA-D3-A3CE	SKCM	TCGA	QRSHLYGIT	DEG_APCC_DBOX_1	0.6421
p.G1362V	DO37405	SKCM	ICGC	QRSHLYGIT	DEG_APCC_DBOX_1	0.6421
p.Y1352H	TCGA-VQ-A8PT	STAD	TCGA	QRSHLYGIT	DEG_APCC_DBOX_1	0.2222
p.Y1352H	DO51776	STAD	ICGC	QRSHLYGIT	DEG_APCC_DBOX_1	0.2222
p.G1362R	DO218828	BRCA	ICGC	QRSHLYGIT	DEG_APCC_DBOX_1	0.6457
p.G1362R	DO225261	BRCA	ICGC	QRSHLYGIT	DEG_APCC_DBOX_1	0.6457
p.G1362R	SIDM01218	Other Solid Cancers	GDSC	QRSHLYGIT	DEG_APCC_DBOX_1	0.6457
p.G1362R	JEG-3	placenta	COSMIC	QRSHLYGIT	DEG_APCC_DBOX_1	0.6457
p.Y1361H	DO233903	GACA	ICGC	QRSHLYGIT	DEG_APCC_DBOX_1	0.6118
p.P1371T	DO229045	LICA	ICGC	QRSHLYGIT	DEG_APCC_DBOX_1	0.1389
p.H1359Q	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	QRSHLYGIT	DEG_APCC_DBOX_1	0.647
p.H1359Q	ACH-000647	Esophageal Cancer	CCLE	QRSHLYGIT	DEG_APCC_DBOX_1	0.647
p.H1359Q	TE-1	oesophagus	COSMIC	QRSHLYGIT	DEG_APCC_DBOX_1	0.647
p.R1357P	SIDM00966	Ovarian Carcinoma	GDSC	QRSHLYGIT	DEG_APCC_DBOX_1	0.7512
p.R1357P	ACH-002182	Ovarian Cancer	CCLE	QRSHLYGIT	DEG_APCC_DBOX_1	0.7512
p.R1357P	OVCA433	ovary	COSMIC	QRSHLYGIT	DEG_APCC_DBOX_1	0.7512

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QRSHLYGIT

Degron related mutations and impact score

Drug responses associated with NID2 mutations

All proteins holding degron of QRSHLYGIT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14112	Nidogen-2	DEG_APCC_DBOX_1	1356:1364	QRSHLYGIT	APC,CDC20,FZR1	0.6989	More...