DegronMD - Q8IV31(TMEM139)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R104H	TCGA-AJ-A3BG	UCEC	TCGA	VPVYEE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.0556
p.R104H	TCGA-AJ-A3BG	UCEC	TCGA	PPPY	ITCH	111:114	Mutation rewiring degron network	0.1389
p.R104H	DO42633	UCEC	ICGC	VPVYEE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.0556
p.R104H	DO42633	UCEC	ICGC	PPPY	ITCH	111:114	Mutation rewiring degron network	0.1389
p.P113L	TCGA-EJ-7317	PRAD	TCGA	PPPY	ITCH	111:114	Mutation altering degron motif	0.6471
p.P113L	DO36365	PRAD	ICGC	PPPY	ITCH	111:114	Mutation altering degron motif	0.6471
p.S115I	TCGA-EO-A22R	UCEC	TCGA	PPPY	ITCH	111:114	Mutation rewiring degron network	0.3056
p.S115I	DO42713	UCEC	ICGC	PPPY	ITCH	111:114	Mutation rewiring degron network	0.3056
p.V96M	TCGA-HU-A4GP	STAD	TCGA	VPVYEE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.2778
p.V96M	DO48005	STAD	ICGC	VPVYEE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.2778
p.Y114H	TCGA-IZ-8195	KIRP	TCGA	PPPY	ITCH	111:114	Mutation altering degron motif	0.7229
p.Y114H	DO44471	KIRP	ICGC	PPPY	ITCH	111:114	Mutation altering degron motif	0.7229
p.G79S	TCGA-MN-A4N4	LUAD	TCGA	VPVYEE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.0556
p.G79S	DO26250	LUAD	ICGC	VPVYEE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.0556
p.A95D	DO234168	ESAD	ICGC	VPVYEE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.3056
p.D83N	DO234171	ESAD	ICGC	VPVYEE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.1667
p.I119M	DO228222	MALY	ICGC	PPPY	ITCH	111:114	Mutation rewiring degron network	0.1944
p.E124K	DO50657	ORCA	ICGC	PPPY	ITCH	111:114	Mutation rewiring degron network	0.0556
p.R104C	SIDM00373	Endometrial Carcinoma	GDSC	VPVYEE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.0556
p.R104C	SIDM00373	Endometrial Carcinoma	GDSC	PPPY	ITCH	111:114	Mutation rewiring degron network	0.1389
p.R104C	ACH-000974	Endometrial/Uterine Cancer	CCLE	VPVYEE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.0556
p.R104C	ACH-000974	Endometrial/Uterine Cancer	CCLE	PPPY	ITCH	111:114	Mutation rewiring degron network	0.1389
p.R104C	ACH-002026	Endometrial/Uterine Cancer	CCLE	VPVYEE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.0556
p.R104C	ACH-002026	Endometrial/Uterine Cancer	CCLE	PPPY	ITCH	111:114	Mutation rewiring degron network	0.1389
p.R104C	SNG-M	endometrium	COSMIC	VPVYEE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.0556
p.R104C	SNG-M	endometrium	COSMIC	PPPY	ITCH	111:114	Mutation rewiring degron network	0.1389
p.R82W	SIDM00614	Hepatocellular Carcinoma	GDSC	VPVYEE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.1389
p.R82W	SIDM01148	Plasma Cell Myeloma	GDSC	VPVYEE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.1389
p.R82W	SIDM01575	Plasma Cell Myeloma	GDSC	VPVYEE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.1389
p.R82W	JHH-7	liver	COSMIC	VPVYEE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.1389
p.R82W	NCI-H929	haematopoietic and lymphoid tissue	COSMIC	VPVYEE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.1389
p.V96A	SIDM00901	Endometrial Carcinoma	GDSC	VPVYEE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.2778
p.V96A	ACH-000940	Endometrial/Uterine Cancer	CCLE	VPVYEE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.2778
p.V96A	AN3-CA	endometrium	COSMIC	VPVYEE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMEM139

UniProt ID: Q8IV31

Entrez ID: 135932

Protein name: Transmembrane protein 139

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMEM139 in