DegronMD

Uniprot ID: Q8IV31

Source protein: Transmembrane protein 139

Source gene: TMEM139

Class: LIG_APCC_ABBA_1

Location: 89:94

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.836

ASA_SCORE: 59.3667

COIL: 0.4943

CONS_SCORE: 0.8582

DSS_SCORE: 0.4619

HELIX: 0.2872

FCONS_SCORE: 1.3594

RIG_SCORE: 0.8057

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R104H	TCGA-AJ-A3BG	UCEC	TCGA	VPVYEE	LIG_APCC_ABBA_1	0.0556
p.R104H	DO42633	UCEC	ICGC	VPVYEE	LIG_APCC_ABBA_1	0.0556
p.V96M	TCGA-HU-A4GP	STAD	TCGA	VPVYEE	LIG_APCC_ABBA_1	0.2778
p.V96M	DO48005	STAD	ICGC	VPVYEE	LIG_APCC_ABBA_1	0.2778
p.G79S	TCGA-MN-A4N4	LUAD	TCGA	VPVYEE	LIG_APCC_ABBA_1	0.0556
p.G79S	DO26250	LUAD	ICGC	VPVYEE	LIG_APCC_ABBA_1	0.0556
p.A95D	DO234168	ESAD	ICGC	VPVYEE	LIG_APCC_ABBA_1	0.3056
p.D83N	DO234171	ESAD	ICGC	VPVYEE	LIG_APCC_ABBA_1	0.1667
p.R104C	SIDM00373	Endometrial Carcinoma	GDSC	VPVYEE	LIG_APCC_ABBA_1	0.0556
p.R104C	ACH-000974	Endometrial/Uterine Cancer	CCLE	VPVYEE	LIG_APCC_ABBA_1	0.0556
p.R104C	ACH-002026	Endometrial/Uterine Cancer	CCLE	VPVYEE	LIG_APCC_ABBA_1	0.0556
p.R104C	SNG-M	endometrium	COSMIC	VPVYEE	LIG_APCC_ABBA_1	0.0556
p.R82W	SIDM00614	Hepatocellular Carcinoma	GDSC	VPVYEE	LIG_APCC_ABBA_1	0.1389
p.R82W	SIDM01148	Plasma Cell Myeloma	GDSC	VPVYEE	LIG_APCC_ABBA_1	0.1389
p.R82W	SIDM01575	Plasma Cell Myeloma	GDSC	VPVYEE	LIG_APCC_ABBA_1	0.1389
p.R82W	JHH-7	liver	COSMIC	VPVYEE	LIG_APCC_ABBA_1	0.1389
p.R82W	NCI-H929	haematopoietic_and_lymphoid_tissue	COSMIC	VPVYEE	LIG_APCC_ABBA_1	0.1389
p.V96A	SIDM00901	Endometrial Carcinoma	GDSC	VPVYEE	LIG_APCC_ABBA_1	0.2778
p.V96A	ACH-000940	Endometrial/Uterine Cancer	CCLE	VPVYEE	LIG_APCC_ABBA_1	0.2778
p.V96A	AN3-CA	endometrium	COSMIC	VPVYEE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IV31	Transmembrane protein 139	LIG_APCC_ABBA_1	89:94	VPVYEE	APC,CDC20,FZR1	0.836	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons