DegronMD - Q16621(NFE2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P77L	TCGA-2W-A8YY	CESC	TCGA	PASTS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.0833
p.P77L	TCGA-2W-A8YY	CESC	TCGA	PPPY	ITCH	80:83	Mutation rewiring degron network	0.25
p.P77L	DO223732	CESC	ICGC	PASTS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.0833
p.P77L	DO223732	CESC	ICGC	PPPY	ITCH	80:83	Mutation rewiring degron network	0.25
p.F76Y	TCGA-94-8035	LUSC	TCGA	PASTS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.0556
p.F76Y	TCGA-94-8035	LUSC	TCGA	PPPY	ITCH	80:83	Mutation rewiring degron network	0.2222
p.F76Y	DO219173	LUSC	ICGC	PASTS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.0556
p.F76Y	DO219173	LUSC	ICGC	PPPY	ITCH	80:83	Mutation rewiring degron network	0.2222
p.A87S	TCGA-AG-3892	READ	TCGA	PASTS	DEG_SPOP_SBC_1	86:90	Mutation altering degron motif	0.6477
p.A87S	DO36394	READ	ICGC	PASTS	DEG_SPOP_SBC_1	86:90	Mutation altering degron motif	0.6477
p.D73Y	TCGA-CD-8536	STAD	TCGA	PPPY	ITCH	80:83	Mutation rewiring degron network	0.1389
p.D73Y	DO47827	STAD	ICGC	PPPY	ITCH	80:83	Mutation rewiring degron network	0.1389
p.H91Y	DO227987	COCA	ICGC	STSHVPDP	DEG_COP1_1	88:95	Mutation altering degron motif	0.6118
p.P82S	DO228377	LICA	ICGC	PPPY	ITCH	80:83	Mutation altering degron motif	0.5641
p.A87E	DO228948	LICA	ICGC	PASTS	DEG_SPOP_SBC_1	86:90	Mutation altering degron motif	0.659
p.P82H	DO228948	LICA	ICGC	PPPY	ITCH	80:83	Mutation altering degron motif	0.6583
p.P79S	DO222405	MELA	ICGC	STSHVPDP	DEG_COP1_1	88:95	Mutation rewiring degron network	0.0833
p.P79S	DO222405	MELA	ICGC	PASTS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1389
p.P79S	DO222405	MELA	ICGC	PPPY	ITCH	80:83	Mutation rewiring degron network	0.3056
p.P86R	SIDM00498	Colorectal Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	86:90	Mutation altering degron motif	0.7512
p.P86R	ACH-000970	Colon/Colorectal Cancer	CCLE	PASTS	DEG_SPOP_SBC_1	86:90	Mutation altering degron motif	0.7512
p.P86R	SNU-C5	large intestine	COSMIC	PASTS	DEG_SPOP_SBC_1	86:90	Mutation altering degron motif	0.7512
p.I70V	SIDM00576	Acute Myeloid Leukemia	GDSC	PPPY	ITCH	80:83	Mutation rewiring degron network	0.0556
p.I70V	ACH-002290	Leukemia	CCLE	PPPY	ITCH	80:83	Mutation rewiring degron network	0.0556
p.I70V	NKM-1	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	80:83	Mutation rewiring degron network	0.0556
p.D94H	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	STSHVPDP	DEG_COP1_1	88:95	Mutation altering degron motif	0.7688
p.D94H	ACH-000845	Lung Cancer	CCLE	STSHVPDP	DEG_COP1_1	88:95	Mutation altering degron motif	0.7688
p.Y83C	ACH-001409	Bladder Cancer	CCLE	PPPY	ITCH	80:83	Mutation altering degron motif	0.7087

Kaplan plot for NFE2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NFE2

UniProt ID: Q16621

Entrez ID: 4778

Protein name: Transcription factor NF-E2 45 kDa subunit (Leucine zipper protein NF-E2) (Nuclear factor, erythroid-derived 2 45 kDa subunit) (p45 NF-E2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NFE2 in