DegronMD

Uniprot ID: Q16621

Source protein: Transcription factor NF-E2 45 kDa subunit

Source gene: NFE2

Class: DEG_COP1_1

Location: 88:95

E3 ligase: COP1

DEGRON score: 0.9925

ASA_SCORE: 67.0625

COIL: 0.9376

CONS_SCORE: 0.4681

DSS_SCORE: 0.4643

HELIX: 0.034

FCONS_SCORE: 0.9593

RIG_SCORE: 0.6299

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D94H	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	STSHVPDP	DEG_COP1_1	0.7688
p.D94H	ACH-000845	Lung Cancer	CCLE	STSHVPDP	DEG_COP1_1	0.7688
p.H91Y	DO227987	COCA	ICGC	STSHVPDP	DEG_COP1_1	0.6118
p.P79S	DO222405	MELA	ICGC	STSHVPDP	DEG_COP1_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16621	Transcription factor NF-E2 45 kDa subunit	DEG_COP1_1	88:95	STSHVPDP	COP1	0.9925	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons