DegronMD - Q16534(HLF)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P33A	TCGA-06-2566	GBM	TCGA	LPLHHE	LIG_APCC_ABBA_1	32:37	Mutation altering degron motif	0.6392
p.P33A	TCGA-06-2566	GBM	TCGA	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation altering degron motif	0.6392
p.P33A	DO11507	GBM	ICGC	LPLHHE	LIG_APCC_ABBA_1	32:37	Mutation altering degron motif	0.6392
p.P33A	DO11507	GBM	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation altering degron motif	0.6392
p.P9T	TCGA-56-7580	LUSC	TCGA	PPPY	ITCH	16:19	Mutation rewiring degron network	0.1389
p.P9T	DO27675	LUSC	ICGC	PPPY	ITCH	16:19	Mutation rewiring degron network	0.1389
p.V21A	TCGA-63-5131	LUSC	TCGA	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation rewiring degron network	0.0556
p.V21A	TCGA-63-5131	LUSC	TCGA	PPPY	ITCH	16:19	Mutation rewiring degron network	0.2778
p.V21A	DO26898	LUSC	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation rewiring degron network	0.0556
p.V21A	DO26898	LUSC	ICGC	PPPY	ITCH	16:19	Mutation rewiring degron network	0.2778
p.S24F	TCGA-FS-A1ZK	SKCM	TCGA	LPLHHE	LIG_APCC_ABBA_1	32:37	Mutation rewiring degron network	0.1111
p.S24F	TCGA-FS-A1ZK	SKCM	TCGA	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation rewiring degron network	0.1389
p.S24F	TCGA-FS-A1ZK	SKCM	TCGA	PPPY	ITCH	16:19	Mutation rewiring degron network	0.1944
p.S24F	DO37474	SKCM	ICGC	LPLHHE	LIG_APCC_ABBA_1	32:37	Mutation rewiring degron network	0.1111
p.S24F	DO37474	SKCM	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation rewiring degron network	0.1389
p.S24F	DO37474	SKCM	ICGC	PPPY	ITCH	16:19	Mutation rewiring degron network	0.1944
p.S15I	DO51918	BLCA	ICGC	PPPY	ITCH	16:19	Mutation rewiring degron network	0.3056
p.P13S	DO227549	COCA	ICGC	PPPY	ITCH	16:19	Mutation rewiring degron network	0.25
p.I15T	DO222762	COCA	ICGC	PPPY	ITCH	16:19	Mutation rewiring degron network	0.3056
p.D45Y	DO222884	COCA	ICGC	LPLHHE	LIG_APCC_ABBA_1	32:37	Mutation rewiring degron network	0.1111
p.D45Y	DO222884	COCA	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation rewiring degron network	0.1111
p.K42E	DO234326	ESAD	ICGC	LPLHHE	LIG_APCC_ABBA_1	32:37	Mutation substituting flanking lysine	0.3056
p.K42E	DO234326	ESAD	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation substituting flanking lysine	0.3056
p.S42N	DO14234	HNSC	ICGC	LPLHHE	LIG_APCC_ABBA_1	32:37	Mutation substituting flanking lysine	0.3056
p.S42N	DO14234	HNSC	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation substituting flanking lysine	0.3056
p.S33L	DO229063	LICA	ICGC	LPLHHE	LIG_APCC_ABBA_1	32:37	Mutation altering degron motif	0.7667
p.S33L	DO229063	LICA	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation altering degron motif	0.7667
p.N10S	DO52239	LIHC	ICGC	PPPY	ITCH	16:19	Mutation rewiring degron network	0.1667
p.Q18K	DO23874	LUAD	ICGC	PPPY	ITCH	16:19	Mutation altering degron motif	0.6944
p.P12S	DO222875	MELA	ICGC	PPPY	ITCH	16:19	Mutation rewiring degron network	0.2222
p.P26S	DO222875	MELA	ICGC	LPLHHE	LIG_APCC_ABBA_1	32:37	Mutation rewiring degron network	0.1667
p.P26S	DO222875	MELA	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation rewiring degron network	0.1944
p.P26S	DO222875	MELA	ICGC	PPPY	ITCH	16:19	Mutation rewiring degron network	0.1389
p.D20E	DO46847	RECA	ICGC	PPPY	ITCH	16:19	Mutation rewiring degron network	0.3056
p.P16L	DO37406	SKCM	ICGC	PPPY	ITCH	16:19	Mutation altering degron motif	0.7582
p.E9K	DO51259	SKCM	ICGC	PPPY	ITCH	16:19	Mutation rewiring degron network	0.1389
p.A35P	DO229224	THCA	ICGC	LPLHHE	LIG_APCC_ABBA_1	32:37	Mutation altering degron motif	0.7503
p.A35P	DO229224	THCA	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation altering degron motif	0.7503
p.S22I	DO42280	UCEC	ICGC	LPLHHE	LIG_APCC_ABBA_1	32:37	Mutation rewiring degron network	0.0556
p.S22I	DO42280	UCEC	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation rewiring degron network	0.0833
p.S22I	DO42280	UCEC	ICGC	PPPY	ITCH	16:19	Mutation rewiring degron network	0.25
p.A34T	DO42608	UCEC	ICGC	LPLHHE	LIG_APCC_ABBA_1	32:37	Mutation altering degron motif	0.7139
p.A34T	DO42608	UCEC	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation altering degron motif	0.7139
p.P36L	DO43755	UCEC	ICGC	LPLHHE	LIG_APCC_ABBA_1	32:37	Mutation altering degron motif	0.7582
p.P36L	DO43755	UCEC	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation altering degron motif	0.7582
p.S32Y	DO41331	UCEC	ICGC	LPLHHE	LIG_APCC_ABBA_1	32:37	Mutation altering degron motif	0.712
p.S32Y	DO41331	UCEC	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation altering degron motif	0.712
p.S37L	DO43971	UCEC	ICGC	LPLHHE	LIG_APCC_ABBA_1	32:37	Mutation altering degron motif	0.7667
p.S37L	DO43971	UCEC	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation altering degron motif	0.7667
p.P7Q	SIDM00845	Burkitt's Lymphoma	GDSC	PPPY	ITCH	16:19	Mutation rewiring degron network	0.0833
p.G20A	SIDM00134	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	16:19	Mutation rewiring degron network	0.3056
p.G20A	ACH-000825	Lung Cancer	CCLE	PPPY	ITCH	16:19	Mutation rewiring degron network	0.3056
p.G20A	HOP-92	lung	COSMIC	PPPY	ITCH	16:19	Mutation rewiring degron network	0.3056
p.L25P	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LPLHHE	LIG_APCC_ABBA_1	32:37	Mutation rewiring degron network	0.1389
p.L25P	SIDM01263	T-Lymphoblastic Leukemia	GDSC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation rewiring degron network	0.1667
p.L25P	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	16:19	Mutation rewiring degron network	0.1667
p.L41I	ACH-000867	Lung Cancer	CCLE	LPLHHE	LIG_APCC_ABBA_1	32:37	Mutation rewiring degron network	0.2222
p.L41I	ACH-000867	Lung Cancer	CCLE	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation rewiring degron network	0.2222
p.L41I	ACH-000979	Prostate Cancer	CCLE	LPLHHE	LIG_APCC_ABBA_1	32:37	Mutation rewiring degron network	0.2222
p.L41I	ACH-000979	Prostate Cancer	CCLE	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation rewiring degron network	0.2222
p.L41I	ChaGo-K-1	lung	COSMIC	LPLHHE	LIG_APCC_ABBA_1	32:37	Mutation rewiring degron network	0.2222
p.L41I	ChaGo-K-1	lung	COSMIC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation rewiring degron network	0.2222
p.L41I	DU-145	prostate	COSMIC	LPLHHE	LIG_APCC_ABBA_1	32:37	Mutation rewiring degron network	0.2222
p.L41I	DU-145	prostate	COSMIC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation rewiring degron network	0.2222
p.P16S	ACH-000979	Prostate Cancer	CCLE	PPPY	ITCH	16:19	Mutation altering degron motif	0.6752
p.P16S	DU-145	prostate	COSMIC	PPPY	ITCH	16:19	Mutation altering degron motif	0.6752
p.A47V	ACH-000998	Colon/Colorectal Cancer	CCLE	LPLHHE	LIG_APCC_ABBA_1	32:37	Mutation rewiring degron network	0.0556
p.A47V	ACH-000998	Colon/Colorectal Cancer	CCLE	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation rewiring degron network	0.0556
p.A47V	CW-2	large intestine	COSMIC	LPLHHE	LIG_APCC_ABBA_1	32:37	Mutation rewiring degron network	0.0556
p.A47V	CW-2	large intestine	COSMIC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation rewiring degron network	0.0556
p.S8T	ACH-002258	Leukemia	CCLE	PPPY	ITCH	16:19	Mutation rewiring degron network	0.1111
p.S8T	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	16:19	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HLF

UniProt ID: Q16534

Entrez ID: 3131

Protein name: Hepatic leukemia factor

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for HLF in