DegronMD - Q16534(HLF)

GO - Biological processes (BP): multicellular organism development [GO:0007275]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511]; skeletal muscle cell differentiation [GO:0035914]

GO - Molecular function (MF): DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; double-stranded DNA binding [GO:0003690]; RNA polymerase II cis-regulatory region sequence-specific DNA... View more >>

GO - Cellular component (CC): chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S33L	DO229063	LICA	ICGC	LPLHHE	LIG_APCC_ABBA_1	32:37	Mutation altering degron motif	0.7667
p.S33L	DO229063	LICA	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation altering degron motif	0.7667
p.S37L	DO43971	UCEC	ICGC	LPLHHE	LIG_APCC_ABBA_1	32:37	Mutation altering degron motif	0.7667
p.S37L	DO43971	UCEC	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation altering degron motif	0.7667
p.P16L	DO37406	SKCM	ICGC	PPPY	ITCH	16:19	Mutation altering degron motif	0.7582
p.P36L	DO43755	UCEC	ICGC	LPLHHE	LIG_APCC_ABBA_1	32:37	Mutation altering degron motif	0.7582
p.P36L	DO43755	UCEC	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation altering degron motif	0.7582
p.A35P	DO229224	THCA	ICGC	LPLHHE	LIG_APCC_ABBA_1	32:37	Mutation altering degron motif	0.7503
p.A35P	DO229224	THCA	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation altering degron motif	0.7503
p.A34T	DO42608	UCEC	ICGC	LPLHHE	LIG_APCC_ABBA_1	32:37	Mutation altering degron motif	0.7139
p.A34T	DO42608	UCEC	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation altering degron motif	0.7139
p.S32Y	DO41331	UCEC	ICGC	LPLHHE	LIG_APCC_ABBA_1	32:37	Mutation altering degron motif	0.712
p.S32Y	DO41331	UCEC	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation altering degron motif	0.712
p.Q18K	DO23874	LUAD	ICGC	PPPY	ITCH	16:19	Mutation altering degron motif	0.6944
p.P16S	ACH-000979	Prostate Cancer	CCLE	PPPY	ITCH	16:19	Mutation altering degron motif	0.6752
p.P16S	DU-145	prostate	COSMIC	PPPY	ITCH	16:19	Mutation altering degron motif	0.6752
p.P33A	TCGA-06-2566	GBM	TCGA	LPLHHE	LIG_APCC_ABBA_1	32:37	Mutation altering degron motif	0.6392
p.P33A	TCGA-06-2566	GBM	TCGA	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation altering degron motif	0.6392
p.P33A	DO11507	GBM	ICGC	LPLHHE	LIG_APCC_ABBA_1	32:37	Mutation altering degron motif	0.6392
p.P33A	DO11507	GBM	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	31:37	Mutation altering degron motif	0.6392

Showing 1 to 20 of 72 entries

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HLF

UniProt ID: Q16534

Entrez ID: 3131

Protein name: Hepatic leukemia factor

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HLF in