DegronMD

Uniprot ID: Q16534

Source protein: Hepatic leukemia factor

Source gene: HLF

Class: LIG_APCC_ABBAyCdc20_2

Location: 31:37

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9541

ASA_SCORE: 79.9429

COIL: 0.8153

CONS_SCORE: 0.4647

DSS_SCORE: 0.4387

HELIX: 0.1351

FCONS_SCORE: 0.9907

RIG_SCORE: 0.7137

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P33A	TCGA-06-2566	GBM	TCGA	KLPLHHE	LIG_APCC_ABBAyCdc20_2	0.6392
p.P33A	DO11507	GBM	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	0.6392
p.V21A	TCGA-63-5131	LUSC	TCGA	KLPLHHE	LIG_APCC_ABBAyCdc20_2	0.0556
p.V21A	DO26898	LUSC	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	0.0556
p.S24F	TCGA-FS-A1ZK	SKCM	TCGA	KLPLHHE	LIG_APCC_ABBAyCdc20_2	0.1389
p.S24F	DO37474	SKCM	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	0.1389
p.D45Y	DO222884	COCA	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	0.1111
p.K42E	DO234326	ESAD	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	0.3056
p.S42N	DO14234	HNSC	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	0.3056
p.S33L	DO229063	LICA	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	0.7667
p.P26S	DO222875	MELA	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	0.1944
p.A35P	DO229224	THCA	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	0.7503
p.S22I	DO42280	UCEC	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A34T	DO42608	UCEC	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	0.7139
p.P36L	DO43755	UCEC	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	0.7582
p.S32Y	DO41331	UCEC	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	0.712
p.S37L	DO43971	UCEC	ICGC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	0.7667
p.L25P	SIDM01263	T-Lymphoblastic Leukemia	GDSC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	0.1667
p.L41I	ACH-000867	Lung Cancer	CCLE	KLPLHHE	LIG_APCC_ABBAyCdc20_2	0.2222
p.L41I	ACH-000979	Prostate Cancer	CCLE	KLPLHHE	LIG_APCC_ABBAyCdc20_2	0.2222
p.L41I	ChaGo-K-1	lung	COSMIC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	0.2222
p.L41I	DU-145	prostate	COSMIC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	0.2222
p.A47V	ACH-000998	Colon/Colorectal Cancer	CCLE	KLPLHHE	LIG_APCC_ABBAyCdc20_2	0.0556
p.A47V	CW-2	large_intestine	COSMIC	KLPLHHE	LIG_APCC_ABBAyCdc20_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16534	Hepatic leukemia factor	LIG_APCC_ABBAyCdc20_2	31:37	KLPLHHE	APC,CDC20,FZR1	0.9541	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KLPLHHE

Degron related mutations and impact score

Drug responses associated with HLF mutations

All proteins holding degron of KLPLHHE