DegronMD

Uniprot ID: Q16534

Source protein: Hepatic leukemia factor

Source gene: HLF

Class: LIG_APCC_ABBA_1

Location: 32:37

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9635

ASA_SCORE: 76.9667

COIL: 0.8288

CONS_SCORE: 0.4692

DSS_SCORE: 0.4588

HELIX: 0.1252

FCONS_SCORE: 0.9959

RIG_SCORE: 0.7165

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P33A	TCGA-06-2566	GBM	TCGA	LPLHHE	LIG_APCC_ABBA_1	0.6392
p.P33A	DO11507	GBM	ICGC	LPLHHE	LIG_APCC_ABBA_1	0.6392
p.S24F	TCGA-FS-A1ZK	SKCM	TCGA	LPLHHE	LIG_APCC_ABBA_1	0.1111
p.S24F	DO37474	SKCM	ICGC	LPLHHE	LIG_APCC_ABBA_1	0.1111
p.D45Y	DO222884	COCA	ICGC	LPLHHE	LIG_APCC_ABBA_1	0.1111
p.K42E	DO234326	ESAD	ICGC	LPLHHE	LIG_APCC_ABBA_1	0.3056
p.S42N	DO14234	HNSC	ICGC	LPLHHE	LIG_APCC_ABBA_1	0.3056
p.S33L	DO229063	LICA	ICGC	LPLHHE	LIG_APCC_ABBA_1	0.7667
p.P26S	DO222875	MELA	ICGC	LPLHHE	LIG_APCC_ABBA_1	0.1667
p.A35P	DO229224	THCA	ICGC	LPLHHE	LIG_APCC_ABBA_1	0.7503
p.S22I	DO42280	UCEC	ICGC	LPLHHE	LIG_APCC_ABBA_1	0.0556
p.A34T	DO42608	UCEC	ICGC	LPLHHE	LIG_APCC_ABBA_1	0.7139
p.P36L	DO43755	UCEC	ICGC	LPLHHE	LIG_APCC_ABBA_1	0.7582
p.S32Y	DO41331	UCEC	ICGC	LPLHHE	LIG_APCC_ABBA_1	0.712
p.S37L	DO43971	UCEC	ICGC	LPLHHE	LIG_APCC_ABBA_1	0.7667
p.L25P	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LPLHHE	LIG_APCC_ABBA_1	0.1389
p.L41I	ACH-000867	Lung Cancer	CCLE	LPLHHE	LIG_APCC_ABBA_1	0.2222
p.L41I	ACH-000979	Prostate Cancer	CCLE	LPLHHE	LIG_APCC_ABBA_1	0.2222
p.L41I	ChaGo-K-1	lung	COSMIC	LPLHHE	LIG_APCC_ABBA_1	0.2222
p.L41I	DU-145	prostate	COSMIC	LPLHHE	LIG_APCC_ABBA_1	0.2222
p.A47V	ACH-000998	Colon/Colorectal Cancer	CCLE	LPLHHE	LIG_APCC_ABBA_1	0.0556
p.A47V	CW-2	large_intestine	COSMIC	LPLHHE	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16534	Hepatic leukemia factor	LIG_APCC_ABBA_1	32:37	LPLHHE	APC,CDC20,FZR1	0.9635	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons