DegronMD - Q8NI35(PATJ)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K947E	SIDM00570	Gastric Carcinoma	GDSC	MKENF	DEG_APCC_KENBOX_2	946:950	Mutation altering degron motif	0.7022
p.K947E	SIDM00578	Neuroblastoma	GDSC	MKENF	DEG_APCC_KENBOX_2	946:950	Mutation altering degron motif	0.7022
p.K947E	SIDM00615	Hepatocellular Carcinoma	GDSC	MKENF	DEG_APCC_KENBOX_2	946:950	Mutation altering degron motif	0.7022
p.K947E	SIDM01372	Pancreatic Carcinoma	GDSC	MKENF	DEG_APCC_KENBOX_2	946:950	Mutation altering degron motif	0.7022
p.K947E	SIDM01618	B-Lymphoblastic Leukemia	GDSC	MKENF	DEG_APCC_KENBOX_2	946:950	Mutation altering degron motif	0.7022
p.K947E	NB1	autonomic ganglia	COSMIC	MKENF	DEG_APCC_KENBOX_2	946:950	Mutation altering degron motif	0.7022
p.K947E	JHH-6	liver	COSMIC	MKENF	DEG_APCC_KENBOX_2	946:950	Mutation altering degron motif	0.7022
p.K947E	NUGC-4	stomach	COSMIC	MKENF	DEG_APCC_KENBOX_2	946:950	Mutation altering degron motif	0.7022
p.P1203R	SIDM00993	Plasma Cell Myeloma	GDSC	PPPY	ITCH	1202:1205	Mutation altering degron motif	0.7512
p.P1203R	AMO-1	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	1202:1205	Mutation altering degron motif	0.7512
p.P1203L	SIDM01237	Hepatocellular Carcinoma	GDSC	PPPY	ITCH	1202:1205	Mutation altering degron motif	0.7582
p.P1203L	C3A	liver	COSMIC	PPPY	ITCH	1202:1205	Mutation altering degron motif	0.7582
p.N1326K	SIDM00789	Colorectal Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	1335:1339	Mutation rewiring degron network	0.0833
p.N1326K	HCT-15	large intestine	COSMIC	VPSSS	DEG_SPOP_SBC_1	1335:1339	Mutation rewiring degron network	0.0833
p.Y940C	SIDM00654	Small Cell Lung Carcinoma	GDSC	MKENF	DEG_APCC_KENBOX_2	946:950	Mutation rewiring degron network	0.1667
p.Y940C	SIDM00694	Other Solid Cancers	GDSC	MKENF	DEG_APCC_KENBOX_2	946:950	Mutation rewiring degron network	0.1667
p.Y940C	SIDM01147	Gastric Carcinoma	GDSC	MKENF	DEG_APCC_KENBOX_2	946:950	Mutation rewiring degron network	0.1667
p.Y940C	SIDM01140	Ovarian Carcinoma	GDSC	MKENF	DEG_APCC_KENBOX_2	946:950	Mutation rewiring degron network	0.1667
p.Y940C	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	MKENF	DEG_APCC_KENBOX_2	946:950	Mutation rewiring degron network	0.1667
p.L46V	SIDM00180	Kidney Carcinoma	GDSC	LSMFYE	LIG_APCC_ABBA_1	35:40	Mutation rewiring degron network	0.1667
p.L46V	LB996-RCC	kidney	COSMIC	LSMFYE	LIG_APCC_ABBA_1	35:40	Mutation rewiring degron network	0.1667
p.T41A	SIDM00364	B-Lymphoblastic Leukemia	GDSC	LSMFYE	LIG_APCC_ABBA_1	35:40	Mutation rewiring degron network	0.3056
p.T41A	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	LSMFYE	LIG_APCC_ABBA_1	35:40	Mutation rewiring degron network	0.3056
p.P1197S	SIDM00694	Other Solid Cancers	GDSC	PPPY	ITCH	1202:1205	Mutation rewiring degron network	0.1944
p.P1197S	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PPPY	ITCH	1202:1205	Mutation rewiring degron network	0.1944
p.P1197S	SIDM00849	Kidney Carcinoma	GDSC	PPPY	ITCH	1202:1205	Mutation rewiring degron network	0.1944
p.P1197S	SIDM00493	Other Solid Cancers	GDSC	PPPY	ITCH	1202:1205	Mutation rewiring degron network	0.1944
p.P1197S	SIDM00844	Burkitt's Lymphoma	GDSC	PPPY	ITCH	1202:1205	Mutation rewiring degron network	0.1944
p.P1197S	SIDM00793	Burkitt's Lymphoma	GDSC	PPPY	ITCH	1202:1205	Mutation rewiring degron network	0.1944
p.P1197S	SIDM01133	Other Solid Cancers	GDSC	PPPY	ITCH	1202:1205	Mutation rewiring degron network	0.1944
p.P1197S	SIDM00257	Neuroblastoma	GDSC	PPPY	ITCH	1202:1205	Mutation rewiring degron network	0.1944
p.P1197S	SIDM00760	Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	1202:1205	Mutation rewiring degron network	0.1944
p.P1197S	SIDM01173	Rhabdomyosarcoma	GDSC	PPPY	ITCH	1202:1205	Mutation rewiring degron network	0.1944
p.P1197S	SIDM00628	Breast Carcinoma	GDSC	PPPY	ITCH	1202:1205	Mutation rewiring degron network	0.1944
p.M1199V	SIDM00345	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	1202:1205	Mutation rewiring degron network	0.25
p.M1199V	LCLC-103H	lung	COSMIC	PPPY	ITCH	1202:1205	Mutation rewiring degron network	0.25
p.L1201R	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	PPPY	ITCH	1202:1205	Mutation rewiring degron network	0.3056
p.L1201R	SW900	lung	COSMIC	PPPY	ITCH	1202:1205	Mutation rewiring degron network	0.3056
p.Y1205H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	1202:1205	Mutation altering degron motif	0.7229
p.Y1205H	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	1202:1205	Mutation altering degron motif	0.7229
p.S1342P	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPSSS	DEG_SPOP_SBC_1	1335:1339	Mutation rewiring degron network	0.25
p.S1342P	Farage	haematopoietic and lymphoid tissue	COSMIC	VPSSS	DEG_SPOP_SBC_1	1335:1339	Mutation rewiring degron network	0.25
p.P192S	SIDM01782	Oral Cavity Carcinoma	GDSC	LKEND	DEG_APCC_KENBOX_2	179:183	Mutation rewiring degron network	0.0833
p.G32R	ASH-3	thyroid	COSMIC	LSMFYE	LIG_APCC_ABBA_1	35:40	Mutation rewiring degron network	0.25
p.M46I	SNU-1040	large intestine	COSMIC	LSMFYE	LIG_APCC_ABBA_1	35:40	Mutation rewiring degron network	0.1667

Kaplan plot for PATJ in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PATJ

UniProt ID: Q8NI35

Entrez ID:

Protein name: InaD-like protein (Inadl protein) (hINADL) (Channel-interacting PDZ domain-containing protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PATJ in