DegronMD

Uniprot ID: Q8NI35

Source protein: InaD-like protein

Source gene: PATJ

Class: LIG_APCC_ABBA_1

Location: 35:40

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.789

ASA_SCORE: 54.65

COIL: 0.0198

CONS_SCORE: 0.33

DSS_SCORE: 0.3325

HELIX: 0.9723

FCONS_SCORE: 0.9647

RIG_SCORE: 0.8338

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L46V	SIDM00180	Kidney Carcinoma	GDSC	LSMFYE	LIG_APCC_ABBA_1	0.1667
p.L46V	LB996-RCC	kidney	COSMIC	LSMFYE	LIG_APCC_ABBA_1	0.1667
p.T41A	SIDM00364	B-Lymphoblastic Leukemia	GDSC	LSMFYE	LIG_APCC_ABBA_1	0.3056
p.T41A	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	LSMFYE	LIG_APCC_ABBA_1	0.3056
p.G32R	ASH-3	thyroid	COSMIC	LSMFYE	LIG_APCC_ABBA_1	0.25
p.M46I	SNU-1040	large_intestine	COSMIC	LSMFYE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NI35	InaD-like protein	LIG_APCC_ABBA_1	35:40	LSMFYE	APC,CDC20,FZR1	0.789	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons