DegronMD

Uniprot ID: Q8NI35

Source protein: InaD-like protein

Source gene: PATJ

Class: DEG_APCC_KENBOX_2

Location: 946:950

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6305

ASA_SCORE: 76.92

COIL: 0.3478

CONS_SCORE: 0.4469

DSS_SCORE: 0.4052

HELIX: 0.196

FCONS_SCORE: 1.1262

RIG_SCORE: 0.7952

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K947E	SIDM00570	Gastric Carcinoma	GDSC	MKENF	DEG_APCC_KENBOX_2	0.7022
p.K947E	SIDM00578	Neuroblastoma	GDSC	MKENF	DEG_APCC_KENBOX_2	0.7022
p.K947E	SIDM00615	Hepatocellular Carcinoma	GDSC	MKENF	DEG_APCC_KENBOX_2	0.7022
p.K947E	SIDM01372	Pancreatic Carcinoma	GDSC	MKENF	DEG_APCC_KENBOX_2	0.7022
p.K947E	SIDM01618	B-Lymphoblastic Leukemia	GDSC	MKENF	DEG_APCC_KENBOX_2	0.7022
p.K947E	NB1	autonomic_ganglia	COSMIC	MKENF	DEG_APCC_KENBOX_2	0.7022
p.K947E	JHH-6	liver	COSMIC	MKENF	DEG_APCC_KENBOX_2	0.7022
p.K947E	NUGC-4	stomach	COSMIC	MKENF	DEG_APCC_KENBOX_2	0.7022
p.Y940C	SIDM00654	Small Cell Lung Carcinoma	GDSC	MKENF	DEG_APCC_KENBOX_2	0.1667
p.Y940C	SIDM00694	Other Solid Cancers	GDSC	MKENF	DEG_APCC_KENBOX_2	0.1667
p.Y940C	SIDM01147	Gastric Carcinoma	GDSC	MKENF	DEG_APCC_KENBOX_2	0.1667
p.Y940C	SIDM01140	Ovarian Carcinoma	GDSC	MKENF	DEG_APCC_KENBOX_2	0.1667
p.Y940C	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	MKENF	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NI35	InaD-like protein	DEG_APCC_KENBOX_2	946:950	MKENF	APC,CDC20,FZR1	0.6305	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons