DegronMD - Q9GZV9(FGF23)

FUNCTION: Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Up-regulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. {ECO:0000250, ECO:0000269|PubMed:11062477, ECO:0000269|PubMed:11409890, ECO:0000269|PubMed:15040831, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:18282132}.

GO - Biological processes (BP): animal organ morphogenesis [GO:0009887]; calcium ion homeostasis [GO:0055074]; cell differentiation [GO:0030154]; cellular phosphate ion homeostasis [GO:0030643]; cellular response to interleukin-6 [GO:0071354]; cellular response to leptin stimulus [GO:0044320]; cellular response to parathyroid horm... View more >>

GO - Molecular function (MF): fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083]; type 1 fibroblast growth factor receptor binding [GO:0005105]

GO - Cellular component (CC): cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
KRAFLPGMN	DEG_APCC_DBOX_1	APC,CDC20,FZR1	Fibroblast growth factor 23	142:150	More..
ERDPLNVLK	DEG_APCC_DBOX_1	APC,CDC20,FZR1	Fibroblast growth factor 23	186:194	More..
PPPY	ITCH	ITCH,NEDD4	Fibroblast growth factor 23	151:154	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R187W	TCGA-12-1598	GBM	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.8634
p.R187W	TCGA-63-5131	LUSC	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.8634
p.R187W	DO222706	COCA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.8634
p.R187W	DO228740	GACA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.8634
p.R187W	DO10871	GBM	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.8634
p.R187W	DO26898	LUSC	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.8634
p.R187W	DO27929	ORCA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.8634
p.Y154H	DO23266	LINC	ICGC	PPPY	ITCH	151:154	Mutation altering degron motif	0.834
p.R143T	TCGA-CV-6948	HNSC	TCGA	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation altering degron motif	0.7876
p.R143T	DO14188	HNSC	ICGC	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation altering degron motif	0.7876
p.L193Q	TCGA-05-4384	LUAD	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.7765
p.L193Q	DO23618	LUAD	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.7765
p.P151L	TCGA-12-1089	GBM	TCGA	PPPY	ITCH	151:154	Mutation altering degron motif	0.7582
p.P151L	DO12346	GBM	ICGC	PPPY	ITCH	151:154	Mutation altering degron motif	0.7582
p.P151L	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	PPPY	ITCH	151:154	Mutation altering degron motif	0.7582
p.P151L	ACH-000823	Esophageal Cancer	CCLE	PPPY	ITCH	151:154	Mutation altering degron motif	0.7582
p.P151L	KYSE-140	oesophagus	COSMIC	PPPY	ITCH	151:154	Mutation altering degron motif	0.7582
p.R187G	ACH-002209	Leukemia	CCLE	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.7568
p.P151A	ACH-001369	Ovarian Cancer	CCLE	PPPY	ITCH	151:154	Mutation altering degron motif	0.7503
p.R187Q	DO220857	MELA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.7329

Showing 1 to 20 of 137 entries

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No resistance data available for this Degron.

Kaplan plot for FGF23 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FGF23

UniProt ID: Q9GZV9

Entrez ID: 8074

Protein name: Fibroblast growth factor 23 (FGF-23) (Phosphatonin) (Tumor-derived hypophosphatemia-inducing factor) [Cleaved into: Fibroblast growth factor 23 N-terminal peptide; Fibroblast growth factor 23 C-terminal peptide]

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for FGF23 in