DegronMD - Q9GZV9(FGF23)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L193Q	TCGA-05-4384	LUAD	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.7765
p.L193Q	DO23618	LUAD	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.7765
p.S180R	TCGA-05-4390	LUAD	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation blocking phosphorylation signal	0.6111
p.S180R	DO23562	LUAD	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation blocking phosphorylation signal	0.6111
p.P151L	TCGA-12-1089	GBM	TCGA	PPPY	ITCH	151:154	Mutation altering degron motif	0.7582
p.P151L	DO12346	GBM	ICGC	PPPY	ITCH	151:154	Mutation altering degron motif	0.7582
p.P151L	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	PPPY	ITCH	151:154	Mutation altering degron motif	0.7582
p.P151L	ACH-000823	Esophageal Cancer	CCLE	PPPY	ITCH	151:154	Mutation altering degron motif	0.7582
p.P151L	KYSE-140	oesophagus	COSMIC	PPPY	ITCH	151:154	Mutation altering degron motif	0.7582
p.R187W	TCGA-12-1598	GBM	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.8634
p.R187W	TCGA-63-5131	LUSC	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.8634
p.R187W	DO222706	COCA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.8634
p.R187W	DO228740	GACA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.8634
p.R187W	DO10871	GBM	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.8634
p.R187W	DO26898	LUSC	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.8634
p.R187W	DO27929	ORCA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.8634
p.R140W	TCGA-13-1492	OV	TCGA	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.2778
p.R140W	TCGA-QU-A6IM	PRAD	TCGA	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.2778
p.R140W	DO229331	BTCA	ICGC	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.2778
p.R140W	DO28065	OV	ICGC	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.2778
p.R140W	DO49852	PRAD	ICGC	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.2778
p.R140W	SIDM00267	Biliary Tract Carcinoma	GDSC	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.2778
p.R140W	ACH-000774	Lung Cancer	CCLE	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.2778
p.R140W	ACH-002312	Gallbladder Cancer	CCLE	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.2778
p.R140W	TGBC24TKB	biliary tract	COSMIC	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.2778
p.R176Q	TCGA-22-4613	LUSC	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.0556
p.R176Q	TCGA-CM-6162	COAD	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.0556
p.R176Q	DO8479	COAD	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.0556
p.R176Q	DO26468	LUSC	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.0556
p.A197D	TCGA-23-2647	OV	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.25
p.A197D	DO32327	OV	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.25
p.A197T	TCGA-24-1470	OV	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.25
p.A197T	DO28010	OV	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.25
p.S185L	TCGA-32-2616	GBM	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.3056
p.S185L	TCGA-85-8287	LUSC	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.3056
p.S185L	DO13462	GBM	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.3056
p.S185L	DO27492	LUSC	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.3056
p.P203L	TCGA-33-AASI	LUSC	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.0833
p.P203L	DO233245	GACA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.0833
p.P203L	DO219129	LUSC	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.0833
p.A144S	TCGA-43-7658	LUSC	TCGA	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation altering degron motif	0.6477
p.A144S	DO27628	LUSC	ICGC	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation altering degron motif	0.6477
p.P151T	TCGA-49-6767	LUAD	TCGA	PPPY	ITCH	151:154	Mutation altering degron motif	0.7031
p.P151T	DO23586	LUAD	ICGC	PPPY	ITCH	151:154	Mutation altering degron motif	0.7031
p.P203T	TCGA-53-A4EZ	LUAD	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.0833
p.P203T	TCGA-BA-A6DA	HNSC	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.0833
p.P203T	DO44448	HNSC	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.0833
p.P203T	DO45319	LUAD	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.0833
p.P189T	TCGA-55-8085	LUAD	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.5919
p.P189T	DO45326	LUAD	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.5919
p.P201A	TCGA-6A-AB49	LUSC	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1389
p.P201A	DO52020	LUSC	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1389
p.R160Q	TCGA-A5-A1OF	UCEC	TCGA	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.0556
p.R160Q	TCGA-A5-A1OF	UCEC	TCGA	PPPY	ITCH	151:154	Mutation rewiring degron network	0.1667
p.R160Q	DO42568	UCEC	ICGC	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.0556
p.R160Q	DO42568	UCEC	ICGC	PPPY	ITCH	151:154	Mutation rewiring degron network	0.1667
p.V192M	TCGA-A8-A06X	BRCA	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.6097
p.V192M	DO5074	BRCA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.6097
p.V192M	DO232047	ORCA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.6097
p.R179Q	TCGA-AN-A0AK	BRCA	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1389
p.R179Q	TCGA-BP-4991	KIRC	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1389
p.R179Q	DO1608	BRCA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1389
p.R179Q	DO233252	GACA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1389
p.R179Q	DO233818	GACA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1389
p.R179Q	DO17653	KIRC	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1389
p.H133N	TCGA-BS-A0UV	UCEC	TCGA	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.0833
p.H133N	DO42793	UCEC	ICGC	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.0833
p.P201S	TCGA-C8-A1HN	BRCA	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1389
p.P201S	DO4756	BRCA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1389
p.R198W	TCGA-CN-4739	HNSC	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.2222
p.R198W	DO227717	COCA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.2222
p.R198W	DO14478	HNSC	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.2222
p.M199I	TCGA-CN-A6V1	HNSC	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1944
p.M199I	TCGA-D9-A6EA	SKCM	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1944
p.M199I	DO52048	HNSC	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1944
p.M199I	DO50290	SKCM	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1944
p.R143T	TCGA-CV-6948	HNSC	TCGA	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation altering degron motif	0.7876
p.R143T	DO14188	HNSC	ICGC	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation altering degron motif	0.7876
p.A181T	TCGA-DC-6154	READ	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1944
p.A181T	TCGA-EI-6917	READ	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1944
p.A181T	DO227745	COCA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1944
p.A181T	DO36523	READ	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1944
p.A181T	DO36881	READ	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1944
p.K142R	TCGA-E7-A541	BLCA	TCGA	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation altering degron motif	0.6126
p.K142R	DO44037	BLCA	ICGC	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation altering degron motif	0.6126
p.R196Q	TCGA-EC-A24G	UCEC	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.2778
p.R196Q	DO40996	UCEC	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.2778
p.P153S	TCGA-EE-A2GC	SKCM	TCGA	PPPY	ITCH	151:154	Mutation altering degron motif	0.5641
p.P153S	DO37839	SKCM	ICGC	PPPY	ITCH	151:154	Mutation altering degron motif	0.5641
p.R196G	TCGA-K4-A4AB	BLCA	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.2778
p.R196G	DO44039	BLCA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.2778
p.L190M	TCGA-O2-A52Q	LUSC	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.711
p.L190M	DO219219	LUSC	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.711
p.E163K	TCGA-YD-A89C	SKCM	TCGA	PPPY	ITCH	151:154	Mutation rewiring degron network	0.0833
p.E163K	DO219501	SKCM	ICGC	PPPY	ITCH	151:154	Mutation rewiring degron network	0.0833
p.E186Q	DO228317	BRCA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.5633
p.E182K	DO227614	COCA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.2222
p.E182K	DO234443	ESAD	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.2222
p.E186G	DO228102	EOPC	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.6087
p.K194R	DO234189	ESAD	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.6126
p.R176W	DO48270	ESCA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.0556
p.G139A	DO233751	GACA	ICGC	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.25
p.Y154H	DO23266	LINC	ICGC	PPPY	ITCH	151:154	Mutation altering degron motif	0.834
p.R140Q	DO52357	LUSC	ICGC	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.2778
p.R187Q	DO220857	MELA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.7329
p.T178I	DO46342	OV	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1111
p.P153L	DO49080	PACA	ICGC	PPPY	ITCH	151:154	Mutation altering degron motif	0.6471
p.P153L	SIDM02013	Colorectal Carcinoma	GDSC	PPPY	ITCH	151:154	Mutation altering degron motif	0.6471
p.M199K	DO35625	PBCA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.1944
p.N191K	SIDM01292	Esophageal Carcinoma	GDSC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.5806
p.K142M	SIDM01016	T-Lymphoblastic Leukemia	GDSC	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation altering degron motif	0.6951
p.K142M	SIDM01263	T-Lymphoblastic Leukemia	GDSC	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation altering degron motif	0.6951
p.K142M	ACH-000995	Leukemia	CCLE	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation altering degron motif	0.6951
p.K142M	Jurkat	haematopoietic and lymphoid tissue	COSMIC	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation altering degron motif	0.6951
p.F134V	SIDM00193	Colorectal Carcinoma	GDSC	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.1111
p.F134V	ACH-000961	Endometrial/Uterine Cancer	CCLE	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.1111
p.F134V	ACH-000991	Colon/Colorectal Cancer	CCLE	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.1111
p.F134V	SNU-81	large intestine	COSMIC	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.1111
p.D184G	SIDM00459	B-Cell Non-Hodgkin's Lymphoma	GDSC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.2778
p.V192L	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.5654
p.V192L	ACH-000878	Lung Cancer	CCLE	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.5654
p.V192L	HCC-15	lung	COSMIC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.5654
p.M149I	SIDM00937	Oral Cavity Carcinoma	GDSC	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation altering degron motif	0.6507
p.M149I	ACH-000832	Head and Neck Cancer	CCLE	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation altering degron motif	0.6507
p.M149I	CAL-27	upper aerodigestive tract	COSMIC	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation altering degron motif	0.6507
p.P152S	SIDM00901	Endometrial Carcinoma	GDSC	PPPY	ITCH	151:154	Mutation altering degron motif	0.6752
p.P152S	ACH-000940	Endometrial/Uterine Cancer	CCLE	PPPY	ITCH	151:154	Mutation altering degron motif	0.6752
p.P152S	AN3-CA	endometrium	COSMIC	PPPY	ITCH	151:154	Mutation altering degron motif	0.6752
p.R198Q	SIDM00500	Colorectal Carcinoma	GDSC	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.2222
p.R198Q	ACH-000959	Colon/Colorectal Cancer	CCLE	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation rewiring degron network	0.2222
p.E163A	ACH-001163	Kidney Cancer	CCLE	PPPY	ITCH	151:154	Mutation rewiring degron network	0.0833
p.P151A	ACH-001369	Ovarian Cancer	CCLE	PPPY	ITCH	151:154	Mutation altering degron motif	0.7503
p.Q156K	ACH-002089	Lung Cancer	CCLE	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.1667
p.Q156K	ACH-002089	Lung Cancer	CCLE	PPPY	ITCH	151:154	Mutation rewiring degron network	0.2778
p.Q156K	201T	lung	COSMIC	KRAFLPGMN	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.1667
p.Q156K	201T	lung	COSMIC	PPPY	ITCH	151:154	Mutation rewiring degron network	0.2778
p.R187G	ACH-002209	Leukemia	CCLE	ERDPLNVLK	DEG_APCC_DBOX_1	186:194	Mutation altering degron motif	0.7568

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FGF23

UniProt ID: Q9GZV9

Entrez ID: 8074

Protein name: Fibroblast growth factor 23 (FGF-23) (Phosphatonin) (Tumor-derived hypophosphatemia-inducing factor) [Cleaved into: Fibroblast growth factor 23 N-terminal peptide; Fibroblast growth factor 23 C-terminal peptide]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FGF23 in