DegronMD

Uniprot ID: Q9GZV9

Source protein: Fibroblast growth factor 23

Source gene: FGF23

Class: DEG_APCC_DBOX_1

Location: 142:150

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9454

ASA_SCORE: 96.5333

COIL: 0.8541

CONS_SCORE: 0.76

DSS_SCORE: 0.2877

HELIX: 0.0238

FCONS_SCORE: 1.018

RIG_SCORE: 0.7225

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R140W	TCGA-13-1492	OV	TCGA	KRAFLPGMN	DEG_APCC_DBOX_1	0.2778
p.R140W	TCGA-QU-A6IM	PRAD	TCGA	KRAFLPGMN	DEG_APCC_DBOX_1	0.2778
p.R140W	DO229331	BTCA	ICGC	KRAFLPGMN	DEG_APCC_DBOX_1	0.2778
p.R140W	DO28065	OV	ICGC	KRAFLPGMN	DEG_APCC_DBOX_1	0.2778
p.R140W	DO49852	PRAD	ICGC	KRAFLPGMN	DEG_APCC_DBOX_1	0.2778
p.R140W	SIDM00267	Biliary Tract Carcinoma	GDSC	KRAFLPGMN	DEG_APCC_DBOX_1	0.2778
p.R140W	ACH-000774	Lung Cancer	CCLE	KRAFLPGMN	DEG_APCC_DBOX_1	0.2778
p.R140W	ACH-002312	Gallbladder Cancer	CCLE	KRAFLPGMN	DEG_APCC_DBOX_1	0.2778
p.R140W	TGBC24TKB	biliary_tract	COSMIC	KRAFLPGMN	DEG_APCC_DBOX_1	0.2778
p.A144S	TCGA-43-7658	LUSC	TCGA	KRAFLPGMN	DEG_APCC_DBOX_1	0.6477
p.A144S	DO27628	LUSC	ICGC	KRAFLPGMN	DEG_APCC_DBOX_1	0.6477
p.R160Q	TCGA-A5-A1OF	UCEC	TCGA	KRAFLPGMN	DEG_APCC_DBOX_1	0.0556
p.R160Q	DO42568	UCEC	ICGC	KRAFLPGMN	DEG_APCC_DBOX_1	0.0556
p.H133N	TCGA-BS-A0UV	UCEC	TCGA	KRAFLPGMN	DEG_APCC_DBOX_1	0.0833
p.H133N	DO42793	UCEC	ICGC	KRAFLPGMN	DEG_APCC_DBOX_1	0.0833
p.R143T	TCGA-CV-6948	HNSC	TCGA	KRAFLPGMN	DEG_APCC_DBOX_1	0.7876
p.R143T	DO14188	HNSC	ICGC	KRAFLPGMN	DEG_APCC_DBOX_1	0.7876
p.K142R	TCGA-E7-A541	BLCA	TCGA	KRAFLPGMN	DEG_APCC_DBOX_1	0.6126
p.K142R	DO44037	BLCA	ICGC	KRAFLPGMN	DEG_APCC_DBOX_1	0.6126
p.G139A	DO233751	GACA	ICGC	KRAFLPGMN	DEG_APCC_DBOX_1	0.25
p.R140Q	DO52357	LUSC	ICGC	KRAFLPGMN	DEG_APCC_DBOX_1	0.2778
p.K142M	SIDM01016	T-Lymphoblastic Leukemia	GDSC	KRAFLPGMN	DEG_APCC_DBOX_1	0.6951
p.K142M	SIDM01263	T-Lymphoblastic Leukemia	GDSC	KRAFLPGMN	DEG_APCC_DBOX_1	0.6951
p.K142M	ACH-000995	Leukemia	CCLE	KRAFLPGMN	DEG_APCC_DBOX_1	0.6951
p.K142M	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	KRAFLPGMN	DEG_APCC_DBOX_1	0.6951
p.F134V	SIDM00193	Colorectal Carcinoma	GDSC	KRAFLPGMN	DEG_APCC_DBOX_1	0.1111
p.F134V	ACH-000961	Endometrial/Uterine Cancer	CCLE	KRAFLPGMN	DEG_APCC_DBOX_1	0.1111
p.F134V	ACH-000991	Colon/Colorectal Cancer	CCLE	KRAFLPGMN	DEG_APCC_DBOX_1	0.1111
p.F134V	SNU-81	large_intestine	COSMIC	KRAFLPGMN	DEG_APCC_DBOX_1	0.1111
p.M149I	SIDM00937	Oral Cavity Carcinoma	GDSC	KRAFLPGMN	DEG_APCC_DBOX_1	0.6507
p.M149I	ACH-000832	Head and Neck Cancer	CCLE	KRAFLPGMN	DEG_APCC_DBOX_1	0.6507
p.M149I	CAL-27	upper_aerodigestive_tract	COSMIC	KRAFLPGMN	DEG_APCC_DBOX_1	0.6507
p.Q156K	ACH-002089	Lung Cancer	CCLE	KRAFLPGMN	DEG_APCC_DBOX_1	0.1667
p.Q156K	201T	lung	COSMIC	KRAFLPGMN	DEG_APCC_DBOX_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KRAFLPGMN

Degron related mutations and impact score

Drug responses associated with FGF23 mutations

All proteins holding degron of KRAFLPGMN

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9GZV9	Fibroblast growth factor 23	DEG_APCC_DBOX_1	142:150	KRAFLPGMN	APC,CDC20,FZR1	0.9454	More...