DegronMD

Uniprot ID: Q9GZV9

Source protein: Fibroblast growth factor 23

Source gene: FGF23

Class: DEG_APCC_DBOX_1

Location: 186:194

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9965

ASA_SCORE: 88.3222

COIL: 0.719

CONS_SCORE: 0.7319

DSS_SCORE: 0.6698

HELIX: 0.2633

FCONS_SCORE: 1.2224

RIG_SCORE: 0.6896

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L193Q	TCGA-05-4384	LUAD	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	0.7765
p.L193Q	DO23618	LUAD	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.7765
p.S180R	TCGA-05-4390	LUAD	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	0.6111
p.S180R	DO23562	LUAD	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.6111
p.R187W	TCGA-12-1598	GBM	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	0.8634
p.R187W	TCGA-63-5131	LUSC	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	0.8634
p.R187W	DO222706	COCA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.8634
p.R187W	DO228740	GACA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.8634
p.R187W	DO10871	GBM	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.8634
p.R187W	DO26898	LUSC	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.8634
p.R187W	DO27929	ORCA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.8634
p.R176Q	TCGA-22-4613	LUSC	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	0.0556
p.R176Q	TCGA-CM-6162	COAD	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	0.0556
p.R176Q	DO8479	COAD	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.0556
p.R176Q	DO26468	LUSC	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.0556
p.A197D	TCGA-23-2647	OV	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	0.25
p.A197D	DO32327	OV	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.25
p.A197T	TCGA-24-1470	OV	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	0.25
p.A197T	DO28010	OV	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.25
p.S185L	TCGA-32-2616	GBM	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	0.3056
p.S185L	TCGA-85-8287	LUSC	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	0.3056
p.S185L	DO13462	GBM	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.3056
p.S185L	DO27492	LUSC	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.3056
p.P203L	TCGA-33-AASI	LUSC	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	0.0833
p.P203L	DO233245	GACA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.0833
p.P203L	DO219129	LUSC	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.0833
p.P203T	TCGA-53-A4EZ	LUAD	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	0.0833
p.P203T	TCGA-BA-A6DA	HNSC	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	0.0833
p.P203T	DO44448	HNSC	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.0833
p.P203T	DO45319	LUAD	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.0833
p.P189T	TCGA-55-8085	LUAD	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	0.5919
p.P189T	DO45326	LUAD	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.5919
p.P201A	TCGA-6A-AB49	LUSC	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	0.1389
p.P201A	DO52020	LUSC	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.1389
p.V192M	TCGA-A8-A06X	BRCA	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	0.6097
p.V192M	DO5074	BRCA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.6097
p.V192M	DO232047	ORCA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.6097
p.R179Q	TCGA-AN-A0AK	BRCA	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	0.1389
p.R179Q	TCGA-BP-4991	KIRC	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	0.1389
p.R179Q	DO1608	BRCA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.1389
p.R179Q	DO233252	GACA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.1389
p.R179Q	DO233818	GACA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.1389
p.R179Q	DO17653	KIRC	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.1389
p.P201S	TCGA-C8-A1HN	BRCA	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	0.1389
p.P201S	DO4756	BRCA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.1389
p.R198W	TCGA-CN-4739	HNSC	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	0.2222
p.R198W	DO227717	COCA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.2222
p.R198W	DO14478	HNSC	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.2222
p.M199I	TCGA-CN-A6V1	HNSC	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	0.1944
p.M199I	TCGA-D9-A6EA	SKCM	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	0.1944
p.M199I	DO52048	HNSC	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.1944
p.M199I	DO50290	SKCM	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.1944
p.A181T	TCGA-DC-6154	READ	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	0.1944
p.A181T	TCGA-EI-6917	READ	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	0.1944
p.A181T	DO227745	COCA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.1944
p.A181T	DO36523	READ	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.1944
p.A181T	DO36881	READ	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.1944
p.R196Q	TCGA-EC-A24G	UCEC	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	0.2778
p.R196Q	DO40996	UCEC	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.2778
p.R196G	TCGA-K4-A4AB	BLCA	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	0.2778
p.R196G	DO44039	BLCA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.2778
p.L190M	TCGA-O2-A52Q	LUSC	TCGA	ERDPLNVLK	DEG_APCC_DBOX_1	0.711
p.L190M	DO219219	LUSC	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.711
p.E186Q	DO228317	BRCA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.5633
p.E182K	DO227614	COCA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.2222
p.E182K	DO234443	ESAD	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.2222
p.E186G	DO228102	EOPC	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.6087
p.K194R	DO234189	ESAD	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.6126
p.R176W	DO48270	ESCA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.0556
p.R187Q	DO220857	MELA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.7329
p.T178I	DO46342	OV	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.1111
p.M199K	DO35625	PBCA	ICGC	ERDPLNVLK	DEG_APCC_DBOX_1	0.1944
p.N191K	SIDM01292	Esophageal Carcinoma	GDSC	ERDPLNVLK	DEG_APCC_DBOX_1	0.5806
p.D184G	SIDM00459	B-Cell Non-Hodgkin's Lymphoma	GDSC	ERDPLNVLK	DEG_APCC_DBOX_1	0.2778
p.V192L	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	ERDPLNVLK	DEG_APCC_DBOX_1	0.5654
p.V192L	ACH-000878	Lung Cancer	CCLE	ERDPLNVLK	DEG_APCC_DBOX_1	0.5654
p.V192L	HCC-15	lung	COSMIC	ERDPLNVLK	DEG_APCC_DBOX_1	0.5654
p.R198Q	SIDM00500	Colorectal Carcinoma	GDSC	ERDPLNVLK	DEG_APCC_DBOX_1	0.2222
p.R198Q	ACH-000959	Colon/Colorectal Cancer	CCLE	ERDPLNVLK	DEG_APCC_DBOX_1	0.2222
p.R187G	ACH-002209	Leukemia	CCLE	ERDPLNVLK	DEG_APCC_DBOX_1	0.7568

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERDPLNVLK

Degron related mutations and impact score

Drug responses associated with FGF23 mutations

All proteins holding degron of ERDPLNVLK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9GZV9	Fibroblast growth factor 23	DEG_APCC_DBOX_1	186:194	ERDPLNVLK	APC,CDC20,FZR1	0.9965	More...