DegronMD - P98153(DGCR2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D440N	TCGA-06-5416	GBM	TCGA	PPPY	ITCH	430:433	Mutation rewiring degron network	0.1389
p.D440N	TCGA-06-5416	GBM	TCGA	PPPY	ITCH	448:451	Mutation rewiring degron network	0.1111
p.L504V	TCGA-22-1000	LUSC	TCGA	ADSSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.1389
p.G422W	TCGA-91-6836	LUAD	TCGA	PPPY	ITCH	430:433	Mutation rewiring degron network	0.1111
p.E452K	TCGA-A4-7287	KIRP	TCGA	PPPY	ITCH	448:451	Mutation rewiring degron network	0.3056
p.G442D	TCGA-AA-A00N	COAD	TCGA	PPPY	ITCH	430:433	Mutation rewiring degron network	0.0833
p.G442D	TCGA-AA-A00N	COAD	TCGA	PPPY	ITCH	448:451	Mutation rewiring degron network	0.1667
p.P430A	TCGA-AC-A23H	BRCA	TCGA	PPPY	ITCH	430:433	Mutation altering degron motif	0.7503
p.D428N	TCGA-AP-A1E0	UCEC	TCGA	PPPY	ITCH	430:433	Mutation rewiring degron network	0.2778
p.R540H	TCGA-AX-A2HJ	UCEC	TCGA	SRSSLNTVV	DEG_APCC_DBOX_1	542:550	Mutation rewiring degron network	0.2778
p.D522N	TCGA-CM-5864	COAD	TCGA	ADSSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.1389
p.H456Y	TCGA-EB-A97M	SKCM	TCGA	PPPY	ITCH	448:451	Mutation rewiring degron network	0.1944
p.T434M	TCGA-IB-7651	PAAD	TCGA	PPPY	ITCH	430:433	Mutation rewiring degron network	0.3056
p.S454F	TCGA-UC-A7PG	CESC	TCGA	PPPY	ITCH	448:451	Mutation rewiring degron network	0.25
p.R451H	DO2587	BRCA	ICGC	PPPY	ITCH	448:451	Mutation altering degron motif	0.8244
p.R451H	DO42713	UCEC	ICGC	PPPY	ITCH	448:451	Mutation altering degron motif	0.8244
p.R451H	TE-4	oesophagus	COSMIC	PPPY	ITCH	448:451	Mutation altering degron motif	0.8244
p.R451H	RMG-I	ovary	COSMIC	PPPY	ITCH	448:451	Mutation altering degron motif	0.8244
p.R451H	NUGC-3	stomach	COSMIC	PPPY	ITCH	448:451	Mutation altering degron motif	0.8244
p.R451H	NH-12	autonomic ganglia	COSMIC	PPPY	ITCH	448:451	Mutation altering degron motif	0.8244
p.R451H	NOS-1	bone	COSMIC	PPPY	ITCH	448:451	Mutation altering degron motif	0.8244
p.R451H	RF-48	stomach	COSMIC	PPPY	ITCH	448:451	Mutation altering degron motif	0.8244
p.R451H	OVMIU	ovary	COSMIC	PPPY	ITCH	448:451	Mutation altering degron motif	0.8244
p.R451H	RERF-LC-FM	lung	COSMIC	PPPY	ITCH	448:451	Mutation altering degron motif	0.8244
p.R451H	KALS-1	central nervous system	COSMIC	PPPY	ITCH	448:451	Mutation altering degron motif	0.8244
p.A459V	DO10244	COAD	ICGC	PPPY	ITCH	448:451	Mutation rewiring degron network	0.1111
p.A459V	DO228142	PBCA	ICGC	PPPY	ITCH	448:451	Mutation rewiring degron network	0.1111
p.A459V	DO43755	UCEC	ICGC	PPPY	ITCH	448:451	Mutation rewiring degron network	0.1111
p.V432A	DO229013	COCA	ICGC	PPPY	ITCH	430:433	Mutation altering degron motif	0.6936
p.V432A	DO229003	COCA	ICGC	PPPY	ITCH	430:433	Mutation altering degron motif	0.6936
p.V432A	DO229005	COCA	ICGC	PPPY	ITCH	430:433	Mutation altering degron motif	0.6936
p.V432A	DO228945	LICA	ICGC	PPPY	ITCH	430:433	Mutation altering degron motif	0.6936
p.V432A	DO231075	LUSC	ICGC	PPPY	ITCH	430:433	Mutation altering degron motif	0.6936
p.V432A	DO231114	LUSC	ICGC	PPPY	ITCH	430:433	Mutation altering degron motif	0.6936
p.R502S	DO228985	LICA	ICGC	ADSSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.0833
p.P437Q	DO232826	NACA	ICGC	PPPY	ITCH	430:433	Mutation substituting flanking lysine	0.3333
p.G443W	DO37421	SKCM	ICGC	PPPY	ITCH	430:433	Mutation rewiring degron network	0.0556
p.G443W	DO37421	SKCM	ICGC	PPPY	ITCH	448:451	Mutation rewiring degron network	0.1944
p.P423S	DO50287	SKCM	ICGC	PPPY	ITCH	430:433	Mutation rewiring degron network	0.1389
p.G440E	DO219466	SKCM	ICGC	PPPY	ITCH	430:433	Mutation rewiring degron network	0.1389
p.G440E	DO219466	SKCM	ICGC	PPPY	ITCH	448:451	Mutation rewiring degron network	0.1111
p.R543C	SIDM00215	Colorectal Carcinoma	GDSC	SRSSLNTVV	DEG_APCC_DBOX_1	542:550	Mutation altering degron motif	0.8301
p.R543C	SNU-283	large intestine	COSMIC	SRSSLNTVV	DEG_APCC_DBOX_1	542:550	Mutation altering degron motif	0.8301
p.P448L	SIDM01175	Other Sarcomas	GDSC	PPPY	ITCH	448:451	Mutation altering degron motif	0.7582
p.P448L	ACH-002309	Sarcoma	CCLE	PPPY	ITCH	448:451	Mutation altering degron motif	0.7582
p.P448L	SW684	soft tissue	COSMIC	PPPY	ITCH	448:451	Mutation altering degron motif	0.7582
p.F461L	ACH-001696	Head and Neck Cancer	CCLE	PPPY	ITCH	448:451	Mutation rewiring degron network	0.0556
p.H425Y	ACH-002396	Bone Cancer	CCLE	PPPY	ITCH	430:433	Mutation rewiring degron network	0.1944
p.H425Y	Sarc9371	bone	COSMIC	PPPY	ITCH	430:433	Mutation rewiring degron network	0.1944
p.R502C	SNU-283	large intestine	COSMIC	ADSSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DGCR2

UniProt ID: P98153

Entrez ID: 9993

Protein name: Integral membrane protein DGCR2/IDD

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DGCR2 in