DegronMD

Uniprot ID: P98153

Source protein: Integral membrane protein DGCR2/IDD

Source gene: DGCR2

Class: DEG_APCC_DBOX_1

Location: 542:550

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7544

ASA_SCORE: 97.3333

COIL: 0.8502

CONS_SCORE: 0.5711

DSS_SCORE: 0.8574

HELIX: 0.0561

FCONS_SCORE: 1.045

RIG_SCORE: 0.6744

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R540H	TCGA-AX-A2HJ	UCEC	TCGA	SRSSLNTVV	DEG_APCC_DBOX_1	0.2778
p.R543C	SIDM00215	Colorectal Carcinoma	GDSC	SRSSLNTVV	DEG_APCC_DBOX_1	0.8301
p.R543C	SNU-283	large_intestine	COSMIC	SRSSLNTVV	DEG_APCC_DBOX_1	0.8301

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98153	Integral membrane protein DGCR2/IDD	DEG_APCC_DBOX_1	542:550	SRSSLNTVV	APC,CDC20,FZR1	0.7544	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons