DegronMD - Q9UM47(NOTCH3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1694W	TCGA-55-A48Y	LUAD	TCGA	FSLHKD	LIG_APCC_ABBA_1	1680:1685	Mutation rewiring degron network	0.0833
p.R1694W	DO222563	BTCA	ICGC	FSLHKD	LIG_APCC_ABBA_1	1680:1685	Mutation rewiring degron network	0.0833
p.R1694W	DO26160	LUAD	ICGC	FSLHKD	LIG_APCC_ABBA_1	1680:1685	Mutation rewiring degron network	0.0833
p.D1685N	TCGA-86-8056	LUAD	TCGA	FSLHKD	LIG_APCC_ABBA_1	1680:1685	Mutation altering degron motif	0.6932
p.D1685N	TCGA-EE-A3JA	SKCM	TCGA	FSLHKD	LIG_APCC_ABBA_1	1680:1685	Mutation altering degron motif	0.6932
p.D1685N	DO24950	LUAD	ICGC	FSLHKD	LIG_APCC_ABBA_1	1680:1685	Mutation altering degron motif	0.6932
p.D1685N	DO47625	SKCM	ICGC	FSLHKD	LIG_APCC_ABBA_1	1680:1685	Mutation altering degron motif	0.6932
p.R2234H	TCGA-A5-A1OF	UCEC	TCGA	PYLTPSPE	DEG_SCF_FBW7_2	2243:2250	Mutation rewiring degron network	0.0833
p.R2234H	DO42568	UCEC	ICGC	PYLTPSPE	DEG_SCF_FBW7_2	2243:2250	Mutation rewiring degron network	0.0833
p.R2207W	TCGA-AM-5821	COAD	TCGA	PPPY	ITCH	2208:2211	Mutation rewiring degron network	0.3056
p.R2207W	DO8240	COAD	ICGC	PPPY	ITCH	2208:2211	Mutation rewiring degron network	0.3056
p.W2255R	TCGA-AX-A3FS	UCEC	TCGA	PYLTPSPE	DEG_SCF_FBW7_2	2243:2250	Mutation rewiring degron network	0.1944
p.W2255R	DO40879	UCEC	ICGC	PYLTPSPE	DEG_SCF_FBW7_2	2243:2250	Mutation rewiring degron network	0.1944
p.H1690Y	TCGA-CU-A3YL	BLCA	TCGA	FSLHKD	LIG_APCC_ABBA_1	1680:1685	Mutation rewiring degron network	0.1944
p.H1690Y	DO834	BLCA	ICGC	FSLHKD	LIG_APCC_ABBA_1	1680:1685	Mutation rewiring degron network	0.1944
p.A2213T	TCGA-D1-A103	UCEC	TCGA	PPPY	ITCH	2208:2211	Mutation rewiring degron network	0.2778
p.A2213T	DO42312	UCEC	ICGC	PPPY	ITCH	2208:2211	Mutation rewiring degron network	0.2778
p.P2209L	TCGA-D1-A1NS	UCEC	TCGA	PPPY	ITCH	2208:2211	Mutation altering degron motif	0.7582
p.P2209L	DO42193	UCEC	ICGC	PPPY	ITCH	2208:2211	Mutation altering degron motif	0.7582
p.P1677S	TCGA-D9-A3Z1	SKCM	TCGA	FSLHKD	LIG_APCC_ABBA_1	1680:1685	Mutation rewiring degron network	0.25
p.P1677S	DO38105	SKCM	ICGC	FSLHKD	LIG_APCC_ABBA_1	1680:1685	Mutation rewiring degron network	0.25
p.P2252T	TCGA-EE-A3AB	SKCM	TCGA	PYLTPSPE	DEG_SCF_FBW7_2	2243:2250	Mutation rewiring degron network	0.2778
p.P2252T	DO38057	SKCM	ICGC	PYLTPSPE	DEG_SCF_FBW7_2	2243:2250	Mutation rewiring degron network	0.2778
p.E2250K	TCGA-EO-A22R	UCEC	TCGA	PYLTPSPE	DEG_SCF_FBW7_2	2243:2250	Mutation altering degron motif	0.7022
p.E2250K	TCGA-EO-A22X	UCEC	TCGA	PYLTPSPE	DEG_SCF_FBW7_2	2243:2250	Mutation altering degron motif	0.7022
p.E2250K	DO43907	UCEC	ICGC	PYLTPSPE	DEG_SCF_FBW7_2	2243:2250	Mutation altering degron motif	0.7022
p.E2250K	DO42713	UCEC	ICGC	PYLTPSPE	DEG_SCF_FBW7_2	2243:2250	Mutation altering degron motif	0.7022
p.P2201S	TCGA-HT-A5R9	LGG	TCGA	PPPY	ITCH	2208:2211	Mutation rewiring degron network	0.1389
p.P2201S	DO48617	LGG	ICGC	PPPY	ITCH	2208:2211	Mutation rewiring degron network	0.1389
p.P2201L	TCGA-MA-AA3Y	CESC	TCGA	PPPY	ITCH	2208:2211	Mutation rewiring degron network	0.1389
p.P2201L	DO219721	CESC	ICGC	PPPY	ITCH	2208:2211	Mutation rewiring degron network	0.1389
p.S1688C	TCGA-XF-A9T5	BLCA	TCGA	FSLHKD	LIG_APCC_ABBA_1	1680:1685	Mutation rewiring degron network	0.25
p.S1688C	DO51925	BLCA	ICGC	FSLHKD	LIG_APCC_ABBA_1	1680:1685	Mutation rewiring degron network	0.25
p.R1693Q	DO222755	COCA	ICGC	FSLHKD	LIG_APCC_ABBA_1	1680:1685	Mutation rewiring degron network	0.1111
p.P2204L	DO234171	ESAD	ICGC	PPPY	ITCH	2208:2211	Mutation rewiring degron network	0.2222
p.G2216E	DO228583	GACA	ICGC	PPPY	ITCH	2208:2211	Mutation rewiring degron network	0.1944
p.A2256G	DO233722	GACA	ICGC	PYLTPSPE	DEG_SCF_FBW7_2	2243:2250	Mutation rewiring degron network	0.1667
p.P2247Q	DO228948	LICA	ICGC	PYLTPSPE	DEG_SCF_FBW7_2	2243:2250	Mutation altering degron motif	0.7035
p.H2254Q	DO231839	LINC	ICGC	PYLTPSPE	DEG_SCF_FBW7_2	2243:2250	Mutation rewiring degron network	0.2222
p.A2213V	DO232861	NACA	ICGC	PPPY	ITCH	2208:2211	Mutation rewiring degron network	0.2778
p.H2217R	DO233292	NACA	ICGC	PPPY	ITCH	2208:2211	Mutation rewiring degron network	0.1667
p.H1690Q	DO46443	OV	ICGC	FSLHKD	LIG_APCC_ABBA_1	1680:1685	Mutation rewiring degron network	0.1944
p.S2203P	DO219881	SKCA	ICGC	PPPY	ITCH	2208:2211	Mutation rewiring degron network	0.1944
p.S2203P	DO218890	SKCA	ICGC	PPPY	ITCH	2208:2211	Mutation rewiring degron network	0.1944
p.E2220G	DO229257	THCA	ICGC	PPPY	ITCH	2208:2211	Mutation rewiring degron network	0.0833
p.P2198A	DO41217	UCEC	ICGC	PPPY	ITCH	2208:2211	Mutation rewiring degron network	0.0556
p.R2234C	SIDM01269	Esophageal Carcinoma	GDSC	PYLTPSPE	DEG_SCF_FBW7_2	2243:2250	Mutation rewiring degron network	0.0833
p.S2257I	SIDM00521	Small Cell Lung Carcinoma	GDSC	PYLTPSPE	DEG_SCF_FBW7_2	2243:2250	Mutation rewiring degron network	0.1389
p.S2257I	ACH-000743	Lung Cancer	CCLE	PYLTPSPE	DEG_SCF_FBW7_2	2243:2250	Mutation rewiring degron network	0.1389
p.S2257I	COR-L95	lung	COSMIC	PYLTPSPE	DEG_SCF_FBW7_2	2243:2250	Mutation rewiring degron network	0.1389
p.L2212M	SIDM00282	Colorectal Carcinoma	GDSC	PPPY	ITCH	2208:2211	Mutation rewiring degron network	0.3056
p.L2212M	ACH-000998	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	2208:2211	Mutation rewiring degron network	0.3056
p.G1692D	SIDM01019	Acute Myeloid Leukemia	GDSC	FSLHKD	LIG_APCC_ABBA_1	1680:1685	Mutation rewiring degron network	0.1389
p.G1692D	ACH-002258	Leukemia	CCLE	FSLHKD	LIG_APCC_ABBA_1	1680:1685	Mutation rewiring degron network	0.1389
p.G1692D	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	FSLHKD	LIG_APCC_ABBA_1	1680:1685	Mutation rewiring degron network	0.1389
p.G1679R	SIDM01187	Breast Carcinoma	GDSC	FSLHKD	LIG_APCC_ABBA_1	1680:1685	Mutation rewiring degron network	0.3056
p.G1679R	ACH-000568	Breast Cancer	CCLE	FSLHKD	LIG_APCC_ABBA_1	1680:1685	Mutation rewiring degron network	0.3056
p.G1679R	UACC-812	breast	COSMIC	FSLHKD	LIG_APCC_ABBA_1	1680:1685	Mutation rewiring degron network	0.3056
p.P2247L	SIDM01608	Endometrial Carcinoma	GDSC	PYLTPSPE	DEG_SCF_FBW7_2	2243:2250	Mutation altering degron motif	0.7582
p.P2247L	ACH-000990	Endometrial/Uterine Cancer	CCLE	PYLTPSPE	DEG_SCF_FBW7_2	2243:2250	Mutation altering degron motif	0.7582
p.Y2221N	ACH-000810	Skin Cancer	CCLE	PPPY	ITCH	2208:2211	Mutation rewiring degron network	0.0556
p.E1670G	ACH-000970	Colon/Colorectal Cancer	CCLE	FSLHKD	LIG_APCC_ABBA_1	1680:1685	Mutation rewiring degron network	0.0556
p.E1670G	SNU-C5	large intestine	COSMIC	FSLHKD	LIG_APCC_ABBA_1	1680:1685	Mutation rewiring degron network	0.0556

Kaplan plot for NOTCH3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NOTCH3

UniProt ID: Q9UM47

Entrez ID: 4854

Protein name: Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NOTCH3 in