DegronMD

Uniprot ID: Q9UM47

Source protein: Neurogenic locus notch homolog protein 3

Source gene: NOTCH3

Class: LIG_APCC_ABBA_1

Location: 1680:1685

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9863

ASA_SCORE: 76.25

COIL: 0.7177

CONS_SCORE: 0.2819

DSS_SCORE: 0.2784

HELIX: 0.1028

FCONS_SCORE: 0.876

RIG_SCORE: 0.7476

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1694W	TCGA-55-A48Y	LUAD	TCGA	FSLHKD	LIG_APCC_ABBA_1	0.0833
p.R1694W	DO222563	BTCA	ICGC	FSLHKD	LIG_APCC_ABBA_1	0.0833
p.R1694W	DO26160	LUAD	ICGC	FSLHKD	LIG_APCC_ABBA_1	0.0833
p.D1685N	TCGA-86-8056	LUAD	TCGA	FSLHKD	LIG_APCC_ABBA_1	0.6932
p.D1685N	TCGA-EE-A3JA	SKCM	TCGA	FSLHKD	LIG_APCC_ABBA_1	0.6932
p.D1685N	DO24950	LUAD	ICGC	FSLHKD	LIG_APCC_ABBA_1	0.6932
p.D1685N	DO47625	SKCM	ICGC	FSLHKD	LIG_APCC_ABBA_1	0.6932
p.H1690Y	TCGA-CU-A3YL	BLCA	TCGA	FSLHKD	LIG_APCC_ABBA_1	0.1944
p.H1690Y	DO834	BLCA	ICGC	FSLHKD	LIG_APCC_ABBA_1	0.1944
p.P1677S	TCGA-D9-A3Z1	SKCM	TCGA	FSLHKD	LIG_APCC_ABBA_1	0.25
p.P1677S	DO38105	SKCM	ICGC	FSLHKD	LIG_APCC_ABBA_1	0.25
p.S1688C	TCGA-XF-A9T5	BLCA	TCGA	FSLHKD	LIG_APCC_ABBA_1	0.25
p.S1688C	DO51925	BLCA	ICGC	FSLHKD	LIG_APCC_ABBA_1	0.25
p.R1693Q	DO222755	COCA	ICGC	FSLHKD	LIG_APCC_ABBA_1	0.1111
p.H1690Q	DO46443	OV	ICGC	FSLHKD	LIG_APCC_ABBA_1	0.1944
p.G1692D	SIDM01019	Acute Myeloid Leukemia	GDSC	FSLHKD	LIG_APCC_ABBA_1	0.1389
p.G1692D	ACH-002258	Leukemia	CCLE	FSLHKD	LIG_APCC_ABBA_1	0.1389
p.G1692D	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	FSLHKD	LIG_APCC_ABBA_1	0.1389
p.G1679R	SIDM01187	Breast Carcinoma	GDSC	FSLHKD	LIG_APCC_ABBA_1	0.3056
p.G1679R	ACH-000568	Breast Cancer	CCLE	FSLHKD	LIG_APCC_ABBA_1	0.3056
p.G1679R	UACC-812	breast	COSMIC	FSLHKD	LIG_APCC_ABBA_1	0.3056
p.E1670G	ACH-000970	Colon/Colorectal Cancer	CCLE	FSLHKD	LIG_APCC_ABBA_1	0.0556
p.E1670G	SNU-C5	large_intestine	COSMIC	FSLHKD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UM47	Neurogenic locus notch homolog protein 3	LIG_APCC_ABBA_1	1680:1685	FSLHKD	APC,CDC20,FZR1	0.9863	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons