DegronMD

Uniprot ID: Q9UM47

Source protein: Neurogenic locus notch homolog protein 3

Source gene: NOTCH3

Class: DEG_SCF_FBW7_2

Location: 2243:2250

E3 ligase: FBXW7

DEGRON score: 0.9919

ASA_SCORE: 87.6

COIL: 0.9466

CONS_SCORE: 0.3703

DSS_SCORE: 0.5828

HELIX: 0.0205

FCONS_SCORE: 1.1116

RIG_SCORE: 0.5726

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2234H	TCGA-A5-A1OF	UCEC	TCGA	PYLTPSPE	DEG_SCF_FBW7_2	0.0833
p.R2234H	DO42568	UCEC	ICGC	PYLTPSPE	DEG_SCF_FBW7_2	0.0833
p.W2255R	TCGA-AX-A3FS	UCEC	TCGA	PYLTPSPE	DEG_SCF_FBW7_2	0.1944
p.W2255R	DO40879	UCEC	ICGC	PYLTPSPE	DEG_SCF_FBW7_2	0.1944
p.P2252T	TCGA-EE-A3AB	SKCM	TCGA	PYLTPSPE	DEG_SCF_FBW7_2	0.2778
p.P2252T	DO38057	SKCM	ICGC	PYLTPSPE	DEG_SCF_FBW7_2	0.2778
p.E2250K	TCGA-EO-A22R	UCEC	TCGA	PYLTPSPE	DEG_SCF_FBW7_2	0.7022
p.E2250K	TCGA-EO-A22X	UCEC	TCGA	PYLTPSPE	DEG_SCF_FBW7_2	0.7022
p.E2250K	DO43907	UCEC	ICGC	PYLTPSPE	DEG_SCF_FBW7_2	0.7022
p.E2250K	DO42713	UCEC	ICGC	PYLTPSPE	DEG_SCF_FBW7_2	0.7022
p.A2256G	DO233722	GACA	ICGC	PYLTPSPE	DEG_SCF_FBW7_2	0.1667
p.P2247Q	DO228948	LICA	ICGC	PYLTPSPE	DEG_SCF_FBW7_2	0.7035
p.H2254Q	DO231839	LINC	ICGC	PYLTPSPE	DEG_SCF_FBW7_2	0.2222
p.R2234C	SIDM01269	Esophageal Carcinoma	GDSC	PYLTPSPE	DEG_SCF_FBW7_2	0.0833
p.S2257I	SIDM00521	Small Cell Lung Carcinoma	GDSC	PYLTPSPE	DEG_SCF_FBW7_2	0.1389
p.S2257I	ACH-000743	Lung Cancer	CCLE	PYLTPSPE	DEG_SCF_FBW7_2	0.1389
p.S2257I	COR-L95	lung	COSMIC	PYLTPSPE	DEG_SCF_FBW7_2	0.1389
p.P2247L	SIDM01608	Endometrial Carcinoma	GDSC	PYLTPSPE	DEG_SCF_FBW7_2	0.7582
p.P2247L	ACH-000990	Endometrial/Uterine Cancer	CCLE	PYLTPSPE	DEG_SCF_FBW7_2	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q04721	Neurogenic locus notch homolog protein 2	DEG_SCF_FBW7_2	2413:2420	PYLTPSPE	FBXW7	0.9375	More...
Q9UM47	Neurogenic locus notch homolog protein 3	DEG_SCF_FBW7_2	2243:2250	PYLTPSPE	FBXW7	0.9919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons