DegronMD - Q04721(NOTCH2)

GO - Biological processes (BP): animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; atrial septum morphogenesis [GO:0060413]; atrioventricular node development [GO:0003162]; axon guidance [GO:0007411]; bone remodeling [GO:0046849]; cell fate determination [GO:0001709]; cellular response to tumor cell [GO:0071228]; cholangiocyte proliferation [GO:1990705]; ciliary body morphogenesis [GO:0061073]; defense response to bacterium [GO:0042742]; embryonic limb morphogenesis [GO:0030326]; glomerular capillary formation [GO:0072104]; glomerular visceral epithelial cell development [GO:0072015]; heart looping [GO:0001947]; hemopoiesis [GO:0030097]; hepatocyte proliferation [GO:0072574]; humoral immune response [GO:0006959]; inflammatory response to antigenic stimulus [GO:0002437]; intrahepatic bile duct development [GO:0035622]; in utero embryonic development [GO:0001701]; left/right axis specification [GO:0070986]; marginal zone B cell differentiation [GO:0002315]; morphogenesis of an epithelial sheet [GO:0002011]; multicellular organism growth [GO:0035264]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; placenta blood vessel development [GO:0060674]; positive regulation of apoptotic process [GO:0043065]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of Ras protein signal transduction [GO:0046579]; proximal tubule development [GO:0072014]; pulmonary valve morphogenesis [GO:0003184]; regulation of actin cytoskeleton reorganization [GO:2000249]; regulation of osteoclast development [GO:2001204]; wound healing [GO:0042060] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P2311R	TCGA-44-A47G	LUAD	TCGA	PREPLPPIV	DEG_APCC_DBOX_1	2297:2305	Mutation rewiring degron network	0.1667
p.P2311R	DO23681	LUAD	ICGC	PREPLPPIV	DEG_APCC_DBOX_1	2297:2305	Mutation rewiring degron network	0.1667
p.S2421Y	TCGA-AX-A06F	UCEC	TCGA	PYLTPSPE	DEG_SCF_FBW7_2	2413:2420	Mutation rewiring degron network	0.3056
p.S2421Y	DO41752	UCEC	ICGC	PYLTPSPE	DEG_SCF_FBW7_2	2413:2420	Mutation rewiring degron network	0.3056
p.R2298W	TCGA-C5-A2LX	CESC	TCGA	PREPLPPIV	DEG_APCC_DBOX_1	2297:2305	Mutation altering degron motif	0.8634
p.R2298W	TCGA-IR-A3LI	CESC	TCGA	PREPLPPIV	DEG_APCC_DBOX_1	2297:2305	Mutation altering degron motif	0.8634
p.R2298W	DO44400	CESC	ICGC	PREPLPPIV	DEG_APCC_DBOX_1	2297:2305	Mutation altering degron motif	0.8634
p.R2298W	DO49004	CESC	ICGC	PREPLPPIV	DEG_APCC_DBOX_1	2297:2305	Mutation altering degron motif	0.8634
p.R2298W	DO232861	NACA	ICGC	PREPLPPIV	DEG_APCC_DBOX_1	2297:2305	Mutation altering degron motif	0.8634
p.S2427R	TCGA-DR-A0ZM	CESC	TCGA	PYLTPSPE	DEG_SCF_FBW7_2	2413:2420	Mutation rewiring degron network	0.1389
p.S2427R	DO6254	CESC	ICGC	PYLTPSPE	DEG_SCF_FBW7_2	2413:2420	Mutation rewiring degron network	0.1389
p.P2422T	DO229384	BTCA	ICGC	PYLTPSPE	DEG_SCF_FBW7_2	2413:2420	Mutation rewiring degron network	0.2778
p.R2298Q	DO233254	GACA	ICGC	PREPLPPIV	DEG_APCC_DBOX_1	2297:2305	Mutation altering degron motif	0.7329
p.S2428L	DO220851	MELA	ICGC	PYLTPSPE	DEG_SCF_FBW7_2	2413:2420	Mutation rewiring degron network	0.1111
p.P2303S	DO220866	MELA	ICGC	PREPLPPIV	DEG_APCC_DBOX_1	2297:2305	Mutation altering degron motif	0.5641
p.L2408H	SIDM00458	Acute Myeloid Leukemia	GDSC	PYLTPSPE	DEG_SCF_FBW7_2	2413:2420	Mutation rewiring degron network	0.1944
p.L2408H	SIDM00422	Hodgkin's Lymphoma	GDSC	PYLTPSPE	DEG_SCF_FBW7_2	2413:2420	Mutation rewiring degron network	0.1944
p.L2408H	SIDM00330	Neuroblastoma	GDSC	PYLTPSPE	DEG_SCF_FBW7_2	2413:2420	Mutation rewiring degron network	0.1944
p.L2408H	SIDM01098	Neuroblastoma	GDSC	PYLTPSPE	DEG_SCF_FBW7_2	2413:2420	Mutation rewiring degron network	0.1944
p.I2304V	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	PREPLPPIV	DEG_APCC_DBOX_1	2297:2305	Mutation altering degron motif	0.5965
p.S2426L	SIDM00153	T-Lymphoblastic Leukemia	GDSC	PYLTPSPE	DEG_SCF_FBW7_2	2413:2420	Mutation rewiring degron network	0.1667
p.P2300S	ACH-002396	Bone Cancer	CCLE	PREPLPPIV	DEG_APCC_DBOX_1	2297:2305	Mutation altering degron motif	0.5641
p.P2300S	Sarc9371	bone	COSMIC	PREPLPPIV	DEG_APCC_DBOX_1	2297:2305	Mutation altering degron motif	0.5641

Kaplan plot for NOTCH2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NOTCH2

UniProt ID: Q04721

Entrez ID: 4853

Protein name: Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NOTCH2 in