DegronMD

Uniprot ID: Q04721

Source protein: Neurogenic locus notch homolog protein 2

Source gene: NOTCH2

Class: DEG_APCC_DBOX_1

Location: 2297:2305

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9932

ASA_SCORE: 105.4556

COIL: 0.9523

CONS_SCORE: 0.2558

DSS_SCORE: 0.6472

HELIX: 0.0266

FCONS_SCORE: 1.053

RIG_SCORE: 0.7084

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2311R	TCGA-44-A47G	LUAD	TCGA	PREPLPPIV	DEG_APCC_DBOX_1	0.1667
p.P2311R	DO23681	LUAD	ICGC	PREPLPPIV	DEG_APCC_DBOX_1	0.1667
p.R2298W	TCGA-C5-A2LX	CESC	TCGA	PREPLPPIV	DEG_APCC_DBOX_1	0.8634
p.R2298W	TCGA-IR-A3LI	CESC	TCGA	PREPLPPIV	DEG_APCC_DBOX_1	0.8634
p.R2298W	DO44400	CESC	ICGC	PREPLPPIV	DEG_APCC_DBOX_1	0.8634
p.R2298W	DO49004	CESC	ICGC	PREPLPPIV	DEG_APCC_DBOX_1	0.8634
p.R2298W	DO232861	NACA	ICGC	PREPLPPIV	DEG_APCC_DBOX_1	0.8634
p.R2298Q	DO233254	GACA	ICGC	PREPLPPIV	DEG_APCC_DBOX_1	0.7329
p.P2303S	DO220866	MELA	ICGC	PREPLPPIV	DEG_APCC_DBOX_1	0.5641
p.I2304V	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	PREPLPPIV	DEG_APCC_DBOX_1	0.5965
p.P2300S	ACH-002396	Bone Cancer	CCLE	PREPLPPIV	DEG_APCC_DBOX_1	0.5641
p.P2300S	Sarc9371	bone	COSMIC	PREPLPPIV	DEG_APCC_DBOX_1	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q04721	Neurogenic locus notch homolog protein 2	DEG_APCC_DBOX_1	2297:2305	PREPLPPIV	APC,CDC20,FZR1	0.9932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons