DegronMD

Uniprot ID: Q04721

Source protein: Neurogenic locus notch homolog protein 2

Source gene: NOTCH2

Class: DEG_SCF_FBW7_2

Location: 2413:2420

E3 ligase: FBXW7

DEGRON score: 0.9375

ASA_SCORE: 50.55

COIL: 0.9163

CONS_SCORE: 0.3875

DSS_SCORE: 0.7506

HELIX: 0.019

FCONS_SCORE: 1.0256

RIG_SCORE: 0.5785

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2421Y	TCGA-AX-A06F	UCEC	TCGA	PYLTPSPE	DEG_SCF_FBW7_2	0.3056
p.S2421Y	DO41752	UCEC	ICGC	PYLTPSPE	DEG_SCF_FBW7_2	0.3056
p.S2427R	TCGA-DR-A0ZM	CESC	TCGA	PYLTPSPE	DEG_SCF_FBW7_2	0.1389
p.S2427R	DO6254	CESC	ICGC	PYLTPSPE	DEG_SCF_FBW7_2	0.1389
p.P2422T	DO229384	BTCA	ICGC	PYLTPSPE	DEG_SCF_FBW7_2	0.2778
p.S2428L	DO220851	MELA	ICGC	PYLTPSPE	DEG_SCF_FBW7_2	0.1111
p.L2408H	SIDM00458	Acute Myeloid Leukemia	GDSC	PYLTPSPE	DEG_SCF_FBW7_2	0.1944
p.L2408H	SIDM00422	Hodgkin's Lymphoma	GDSC	PYLTPSPE	DEG_SCF_FBW7_2	0.1944
p.L2408H	SIDM00330	Neuroblastoma	GDSC	PYLTPSPE	DEG_SCF_FBW7_2	0.1944
p.L2408H	SIDM01098	Neuroblastoma	GDSC	PYLTPSPE	DEG_SCF_FBW7_2	0.1944
p.S2426L	SIDM00153	T-Lymphoblastic Leukemia	GDSC	PYLTPSPE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q04721	Neurogenic locus notch homolog protein 2	DEG_SCF_FBW7_2	2413:2420	PYLTPSPE	FBXW7	0.9375	More...
Q9UM47	Neurogenic locus notch homolog protein 3	DEG_SCF_FBW7_2	2243:2250	PYLTPSPE	FBXW7	0.9919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons