DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPPY
Uniprot ID:
Q6VUC0
Source protein:
Transcription factor AP-2-epsilon
Source gene:
TFAP2E
Class:
ITCH
Location:
56:59
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.9747
ASA_SCORE:
68.775
COIL:
0.9788
CONS_SCORE:
0.641
DSS_SCORE:
0.5222
HELIX:
0.0093
FCONS_SCORE:
1.3497
RIG_SCORE:
0.6359
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P52Q
DO222641
BTCA
ICGC
PPPY
ITCH
0.2222
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Drug responses associated with TFAP2E mutations
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Cancer
Mutation (In Degron?)
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Drug
IC50
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All proteins holding degron of PPPY
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96DV4
39S ribosomal protein L38, mitochondrial
ITCH
347:350
PPPY
ITCH,NEDD4
0.6466
More...
O15072
A disintegrin and metalloproteinase with thrombospondin motifs 3
ITCH
1058:1061
PPPY
ITCH,NEDD4
0.9797
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Q13625
Apoptosis-stimulating of p53 protein 2
ITCH
871:874
PPPY
ITCH,NEDD4
0.9885
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P54259
Atrophin-1
ITCH
445:448
PPPY
ITCH,NEDD4
0.973
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P54259
Atrophin-1
ITCH
636:639
PPPY
ITCH,NEDD4
0.9909
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Q8WXX7
Autism susceptibility gene 2 protein
ITCH
516:519
PPPY
ITCH,NEDD4
0.9979
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O00512
B-cell CLL/lymphoma 9 protein
ITCH
515:518
PPPY
ITCH,NEDD4
0.9973
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Q86UU0
B-cell CLL/lymphoma 9-like protein
ITCH
561:564
PPPY
ITCH,NEDD4
0.9923
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O95395
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3
ITCH
285:288
PPPY
ITCH,NEDD4
0.5532
More...
O95415
Brain protein I3
ITCH
39:42
PPPY
ITCH,NEDD4
0.9496
More...
Q15018
BRISC complex subunit Abraxas 2
ITCH
305:308
PPPY
ITCH,NEDD4
0.9939
More...
Q9P203
BTB/POZ domain-containing protein 7
ITCH
762:765
PPPY
ITCH,NEDD4
0.9575
More...
Q9Y6W3
Calpain-7
ITCH
624:627
PPPY
ITCH,NEDD4
0.5393
More...
Q8WXE0
Caskin-2
ITCH
751:754
PPPY
ITCH,NEDD4
0.6879
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Q9H305
Cell death-inducing p53-target protein 1
ITCH
6:9
PPPY
ITCH,NEDD4
0.9945
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Q9H305
Cell death-inducing p53-target protein 1
ITCH
51:54
PPPY
ITCH,NEDD4
0.9943
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Q16630
Cleavage and polyadenylation specificity factor subunit 6
ITCH
387:390
PPPY
ITCH,NEDD4
0.9919
More...
Q8WXI2
Connector enhancer of kinase suppressor of ras 2
ITCH
704:707
PPPY
ITCH,NEDD4
0.9478
More...
Q86YQ8
Copine-8
ITCH
550:553
PPPY
ITCH,NEDD4
0.743
More...
Q6UUV7
CREB-regulated transcription coactivator 3
ITCH
445:448
PPPY
ITCH,NEDD4
0.998
More...
Q96J86
Cysteine and tyrosine-rich protein 1
ITCH
113:116
PPPY
ITCH,NEDD4
0.9396
More...
Q96J86
Cysteine and tyrosine-rich protein 1
ITCH
129:132
PPPY
ITCH,NEDD4
0.9428
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Q96J86
Cysteine and tyrosine-rich protein 1
ITCH
145:148
PPPY
ITCH,NEDD4
0.9794
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Q9H1C7
Cysteine-rich and transmembrane domain-containing protein 1
ITCH
6:9
PPPY
ITCH,NEDD4
0.9391
More...
Q9BTC0
Death-inducer obliterator 1
ITCH
1817:1820
PPPY
ITCH,NEDD4
0.9967
More...
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