DegronMD - Q08345(DDR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P482H	TCGA-18-3421	LUSC	TCGA	PPPY	ITCH	481:484	Mutation altering degron motif	0.7694
p.P482H	DO27652	LUSC	ICGC	PPPY	ITCH	481:484	Mutation altering degron motif	0.7694
p.P487L	TCGA-6A-AB49	LUSC	TCGA	PPPY	ITCH	481:484	Mutation rewiring degron network	0.25
p.P487L	DO52020	LUSC	ICGC	PPPY	ITCH	481:484	Mutation rewiring degron network	0.25
p.R475C	TCGA-AJ-A8CW	UCEC	TCGA	PPPY	ITCH	481:484	Mutation rewiring degron network	0.1667
p.E480K	TCGA-AN-A046	BRCA	TCGA	PPPY	ITCH	481:484	Mutation rewiring degron network	0.3056
p.E480K	DO1285	BRCA	ICGC	PPPY	ITCH	481:484	Mutation rewiring degron network	0.3056
p.R488Q	TCGA-B5-A1MX	UCEC	TCGA	PPPY	ITCH	481:484	Mutation rewiring degron network	0.2222
p.R488Q	DO41999	UCEC	ICGC	PPPY	ITCH	481:484	Mutation rewiring degron network	0.2222
p.R488Q	SIDM01062	Breast Carcinoma	GDSC	PPPY	ITCH	481:484	Mutation rewiring degron network	0.2222
p.R488Q	HDQ-P1	breast	COSMIC	PPPY	ITCH	481:484	Mutation rewiring degron network	0.2222
p.P493L	TCGA-D3-A8GI	SKCM	TCGA	PPPY	ITCH	481:484	Mutation rewiring degron network	0.0833
p.P483S	TCGA-EE-A29M	SKCM	TCGA	PPPY	ITCH	481:484	Mutation altering degron motif	0.5641
p.P483S	TCGA-FS-A1ZW	SKCM	TCGA	PPPY	ITCH	481:484	Mutation altering degron motif	0.5641
p.P483S	DO37519	SKCM	ICGC	PPPY	ITCH	481:484	Mutation altering degron motif	0.5641
p.P483S	DO37404	SKCM	ICGC	PPPY	ITCH	481:484	Mutation altering degron motif	0.5641
p.P483L	TCGA-EE-A29M	SKCM	TCGA	PPPY	ITCH	481:484	Mutation altering degron motif	0.6471
p.P483L	TCGA-FS-A1ZW	SKCM	TCGA	PPPY	ITCH	481:484	Mutation altering degron motif	0.6471
p.G477C	TCGA-EY-A215	UCEC	TCGA	PPPY	ITCH	481:484	Mutation rewiring degron network	0.2222
p.E486K	TCGA-XT-AASU	MESO	TCGA	PPPY	ITCH	481:484	Mutation rewiring degron network	0.2778
p.R490H	DO233267	GACA	ICGC	PPPY	ITCH	481:484	Mutation rewiring degron network	0.1667
p.E480Q	DO229266	LMS	ICGC	PPPY	ITCH	481:484	Mutation rewiring degron network	0.3056
p.V472M	ACH-000767	Lung Cancer	CCLE	PPPY	ITCH	481:484	Mutation rewiring degron network	0.0833
p.V472M	NCI-H526	lung	COSMIC	PPPY	ITCH	481:484	Mutation rewiring degron network	0.0833
p.D484E	OVMIU	ovary	COSMIC	PPPY	ITCH	481:484	Mutation altering degron motif	0.6758

Kaplan plot for DDR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DDR1

UniProt ID: Q08345

Entrez ID: 780

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DDR1 in