DegronMD - Q3B7T3(BEAN1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T199N	TCGA-AP-A1DM	UCEC	TCGA	DSGSGHS	DEG_SCF_TRCP1_1	183:189	Mutation rewiring degron network	0.0556
p.A141T	DO9756	COAD	ICGC	PPGY	ITCH	145:148	Mutation rewiring degron network	0.2222
p.G159R	DO230334	COCA	ICGC	PPPY	ITCH	166:169	Mutation rewiring degron network	0.1389
p.G159R	DO229003	COCA	ICGC	PPPY	ITCH	166:169	Mutation rewiring degron network	0.1389
p.G159R	DO229005	COCA	ICGC	PPPY	ITCH	166:169	Mutation rewiring degron network	0.1389
p.G159R	DO229505	LAML	ICGC	PPPY	ITCH	166:169	Mutation rewiring degron network	0.1389
p.G159R	DO228947	LICA	ICGC	PPPY	ITCH	166:169	Mutation rewiring degron network	0.1389
p.G159R	DO230556	LUSC	ICGC	PPPY	ITCH	166:169	Mutation rewiring degron network	0.1389
p.G145D	DO222501	COCA	ICGC	PPGY	ITCH	145:148	Mutation altering degron motif	0.7198
p.G157C	DO228976	LICA	ICGC	PPGY	ITCH	145:148	Mutation rewiring degron network	0.0833
p.G157C	DO228976	LICA	ICGC	PPPY	ITCH	166:169	Mutation rewiring degron network	0.0833
p.A176E	DO44714	LICA	ICGC	DSGSGHS	DEG_SCF_TRCP1_1	183:189	Mutation rewiring degron network	0.1389
p.A176E	DO44714	LICA	ICGC	PPPY	ITCH	166:169	Mutation rewiring degron network	0.1389
p.H136Y	DO231577	LINC	ICGC	PPGY	ITCH	145:148	Mutation rewiring degron network	0.0833
p.R141K	DO222710	MELA	ICGC	PPGY	ITCH	145:148	Mutation rewiring degron network	0.2222
p.Q153K	DO52124	PAEN	ICGC	PPGY	ITCH	145:148	Mutation rewiring degron network	0.1944
p.N199S	DO228146	PBCA	ICGC	DSGSGHS	DEG_SCF_TRCP1_1	183:189	Mutation rewiring degron network	0.0556
p.G168R	DO229462	SKCA	ICGC	PPPY	ITCH	166:169	Mutation altering degron motif	0.7568
p.G159E	DO229470	SKCA	ICGC	PPPY	ITCH	166:169	Mutation rewiring degron network	0.1389
p.G151R	DO37659	SKCM	ICGC	PPGY	ITCH	145:148	Mutation rewiring degron network	0.25
p.S192T	DO229268	THCA	ICGC	DSGSGHS	DEG_SCF_TRCP1_1	183:189	Mutation rewiring degron network	0.25
p.Q182H	DO42304	UCEC	ICGC	DSGSGHS	DEG_SCF_TRCP1_1	183:189	Mutation rewiring degron network	0.3056
p.H188Q	SIDM00614	Hepatocellular Carcinoma	GDSC	DSGSGHS	DEG_SCF_TRCP1_1	183:189	Mutation altering degron motif	0.647
p.H188Q	SIDM01199	Hepatocellular Carcinoma	GDSC	DSGSGHS	DEG_SCF_TRCP1_1	183:189	Mutation altering degron motif	0.647
p.H188Q	SIDM01004	Chronic Myelogenous Leukemia	GDSC	DSGSGHS	DEG_SCF_TRCP1_1	183:189	Mutation altering degron motif	0.647
p.H188Q	SIDM00364	B-Lymphoblastic Leukemia	GDSC	DSGSGHS	DEG_SCF_TRCP1_1	183:189	Mutation altering degron motif	0.647
p.H188Q	SIDM00410	Other Blood Cancers	GDSC	DSGSGHS	DEG_SCF_TRCP1_1	183:189	Mutation altering degron motif	0.647
p.H188Q	SIDM00026	Other Solid Cancers	GDSC	DSGSGHS	DEG_SCF_TRCP1_1	183:189	Mutation altering degron motif	0.647
p.H188Q	YT	haematopoietic and lymphoid tissue	COSMIC	DSGSGHS	DEG_SCF_TRCP1_1	183:189	Mutation altering degron motif	0.647
p.H188Q	JHH-7	liver	COSMIC	DSGSGHS	DEG_SCF_TRCP1_1	183:189	Mutation altering degron motif	0.647
p.H188Q	SNU-423	liver	COSMIC	DSGSGHS	DEG_SCF_TRCP1_1	183:189	Mutation altering degron motif	0.647
p.H188Q	KCL-22	haematopoietic and lymphoid tissue	COSMIC	DSGSGHS	DEG_SCF_TRCP1_1	183:189	Mutation altering degron motif	0.647
p.H188Q	TASK1	bone	COSMIC	DSGSGHS	DEG_SCF_TRCP1_1	183:189	Mutation altering degron motif	0.647
p.H188Q	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	DSGSGHS	DEG_SCF_TRCP1_1	183:189	Mutation altering degron motif	0.647
p.T163M	SIDM00393	Gastric Carcinoma	GDSC	PPPY	ITCH	166:169	Mutation rewiring degron network	0.25
p.T163M	SK-GT-2	stomach	COSMIC	PPPY	ITCH	166:169	Mutation rewiring degron network	0.25
p.R198K	SIDM00860	Head and Neck Carcinoma	GDSC	DSGSGHS	DEG_SCF_TRCP1_1	183:189	Mutation rewiring degron network	0.0833
p.R198K	ACH-000846	Head and Neck Cancer	CCLE	DSGSGHS	DEG_SCF_TRCP1_1	183:189	Mutation rewiring degron network	0.0833
p.V152I	ACH-000309	Lung Cancer	CCLE	PPGY	ITCH	145:148	Mutation rewiring degron network	0.2222
p.E167Q	ACH-000921	Lung Cancer	CCLE	PPPY	ITCH	166:169	Mutation altering degron motif	0.6744

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BEAN1

UniProt ID: Q3B7T3

Entrez ID: 146227

Protein name: Protein BEAN1 (Brain-expressed protein associating with Nedd4 homolog) (BEAN)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BEAN1 in