DegronMD

Uniprot ID: Q3B7T3

Source protein: Protein BEAN1

Source gene: BEAN1

Class: DEG_SCF_TRCP1_1

Location: 183:189

E3 ligase: BTRC

DEGRON score: 0.9173

ASA_SCORE: 64.5429

COIL: 0.892

CONS_SCORE: 0.3741

DSS_SCORE: 0.8079

HELIX: 0.0574

FCONS_SCORE: 0.8116

RIG_SCORE: 0.4662

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T199N	TCGA-AP-A1DM	UCEC	TCGA	DSGSGHS	DEG_SCF_TRCP1_1	0.0556
p.A176E	DO44714	LICA	ICGC	DSGSGHS	DEG_SCF_TRCP1_1	0.1389
p.N199S	DO228146	PBCA	ICGC	DSGSGHS	DEG_SCF_TRCP1_1	0.0556
p.S192T	DO229268	THCA	ICGC	DSGSGHS	DEG_SCF_TRCP1_1	0.25
p.Q182H	DO42304	UCEC	ICGC	DSGSGHS	DEG_SCF_TRCP1_1	0.3056
p.H188Q	SIDM00614	Hepatocellular Carcinoma	GDSC	DSGSGHS	DEG_SCF_TRCP1_1	0.647
p.H188Q	SIDM01199	Hepatocellular Carcinoma	GDSC	DSGSGHS	DEG_SCF_TRCP1_1	0.647
p.H188Q	SIDM01004	Chronic Myelogenous Leukemia	GDSC	DSGSGHS	DEG_SCF_TRCP1_1	0.647
p.H188Q	SIDM00364	B-Lymphoblastic Leukemia	GDSC	DSGSGHS	DEG_SCF_TRCP1_1	0.647
p.H188Q	SIDM00410	Other Blood Cancers	GDSC	DSGSGHS	DEG_SCF_TRCP1_1	0.647
p.H188Q	SIDM00026	Other Solid Cancers	GDSC	DSGSGHS	DEG_SCF_TRCP1_1	0.647
p.H188Q	YT	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSGHS	DEG_SCF_TRCP1_1	0.647
p.H188Q	JHH-7	liver	COSMIC	DSGSGHS	DEG_SCF_TRCP1_1	0.647
p.H188Q	SNU-423	liver	COSMIC	DSGSGHS	DEG_SCF_TRCP1_1	0.647
p.H188Q	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSGHS	DEG_SCF_TRCP1_1	0.647
p.H188Q	TASK1	bone	COSMIC	DSGSGHS	DEG_SCF_TRCP1_1	0.647
p.H188Q	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSGHS	DEG_SCF_TRCP1_1	0.647
p.R198K	SIDM00860	Head and Neck Carcinoma	GDSC	DSGSGHS	DEG_SCF_TRCP1_1	0.0833
p.R198K	ACH-000846	Head and Neck Cancer	CCLE	DSGSGHS	DEG_SCF_TRCP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3B7T3	Protein BEAN1	DEG_SCF_TRCP1_1	183:189	DSGSGHS	BTRC	0.9173	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons