DegronMD - Q9H0F5(RNF38)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E313Q	TCGA-21-5783	LUSC	TCGA	SRSPLQRIE	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.2222
p.E313Q	DO27437	LUSC	ICGC	SRSPLQRIE	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.2222
p.Q299L	TCGA-97-A4M0	LUAD	TCGA	SRSPLQRIE	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.2778
p.Q299L	DO218935	LUAD	ICGC	SRSPLQRIE	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.2778
p.L319F	TCGA-BH-A18G	BRCA	TCGA	SRSPLQRIE	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.0556
p.L319F	DO3686	BRCA	ICGC	SRSPLQRIE	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.0556
p.P295S	TCGA-D3-A2JC	SKCM	TCGA	SRSPLQRIE	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.1667
p.P295S	DO47578	SKCM	ICGC	SRSPLQRIE	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.1667
p.P386S	TCGA-DU-6407	LGG	TCGA	PPPY	ITCH	381:384	Mutation rewiring degron network	0.2778
p.P386S	DO22295	LGG	ICGC	PPPY	ITCH	381:384	Mutation rewiring degron network	0.2778
p.S303L	TCGA-EO-A3B0	UCEC	TCGA	SRSPLQRIE	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.6556
p.S303L	DO219773	UCEC	ICGC	SRSPLQRIE	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.6556
p.E311K	TCGA-EY-A1GS	UCEC	TCGA	SRSPLQRIE	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.2778
p.E311K	DO43162	UCEC	ICGC	SRSPLQRIE	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.2778
p.P382L	DO229054	LICA	ICGC	PPPY	ITCH	381:384	Mutation altering degron motif	0.7582
p.G291D	SIDM01470	Acute Myeloid Leukemia	GDSC	SRSPLQRIE	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.0556
p.G291D	ACH-000387	Leukemia	CCLE	SRSPLQRIE	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.0556
p.V389A	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	381:384	Mutation rewiring degron network	0.1944
p.V382A	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	381:384	Mutation altering degron motif	0.6936
p.A383P	TE-4	oesophagus	COSMIC	PPPY	ITCH	381:384	Mutation altering degron motif	0.7503
p.P311L	NCI-H1155	lung	COSMIC	SRSPLQRIE	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.2778
p.V303A	PA-TU-8988T	pancreas	COSMIC	SRSPLQRIE	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.6936

Kaplan plot for RNF38 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RNF38

UniProt ID: Q9H0F5

Entrez ID: 152006

Protein name: E3 ubiquitin-protein ligase RNF38 (EC 2.3.2.27) (RING finger protein 38) (RING-type E3 ubiquitin transferase RNF38)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RNF38 in