DegronMD

Uniprot ID: Q9H0F5

Source protein: E3 ubiquitin-protein ligase RNF38

Source gene: RNF38

Class: DEG_APCC_DBOX_1

Location: 301:309

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.572

ASA_SCORE: 95.0222

COIL: 0.7806

CONS_SCORE: 0.3898

DSS_SCORE: 0.65

HELIX: 0.183

FCONS_SCORE: 0.9812

RIG_SCORE: 0.7097

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E313Q	TCGA-21-5783	LUSC	TCGA	SRSPLQRIE	DEG_APCC_DBOX_1	0.2222
p.E313Q	DO27437	LUSC	ICGC	SRSPLQRIE	DEG_APCC_DBOX_1	0.2222
p.Q299L	TCGA-97-A4M0	LUAD	TCGA	SRSPLQRIE	DEG_APCC_DBOX_1	0.2778
p.Q299L	DO218935	LUAD	ICGC	SRSPLQRIE	DEG_APCC_DBOX_1	0.2778
p.L319F	TCGA-BH-A18G	BRCA	TCGA	SRSPLQRIE	DEG_APCC_DBOX_1	0.0556
p.L319F	DO3686	BRCA	ICGC	SRSPLQRIE	DEG_APCC_DBOX_1	0.0556
p.P295S	TCGA-D3-A2JC	SKCM	TCGA	SRSPLQRIE	DEG_APCC_DBOX_1	0.1667
p.P295S	DO47578	SKCM	ICGC	SRSPLQRIE	DEG_APCC_DBOX_1	0.1667
p.S303L	TCGA-EO-A3B0	UCEC	TCGA	SRSPLQRIE	DEG_APCC_DBOX_1	0.6556
p.S303L	DO219773	UCEC	ICGC	SRSPLQRIE	DEG_APCC_DBOX_1	0.6556
p.E311K	TCGA-EY-A1GS	UCEC	TCGA	SRSPLQRIE	DEG_APCC_DBOX_1	0.2778
p.E311K	DO43162	UCEC	ICGC	SRSPLQRIE	DEG_APCC_DBOX_1	0.2778
p.G291D	SIDM01470	Acute Myeloid Leukemia	GDSC	SRSPLQRIE	DEG_APCC_DBOX_1	0.0556
p.G291D	ACH-000387	Leukemia	CCLE	SRSPLQRIE	DEG_APCC_DBOX_1	0.0556
p.P311L	NCI-H1155	lung	COSMIC	SRSPLQRIE	DEG_APCC_DBOX_1	0.2778
p.V303A	PA-TU-8988T	pancreas	COSMIC	SRSPLQRIE	DEG_APCC_DBOX_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H0F5	E3 ubiquitin-protein ligase RNF38	DEG_APCC_DBOX_1	301:309	SRSPLQRIE	APC,CDC20,FZR1	0.572	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons