DegronMD - P20936(RASA1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T983N	TCGA-AA-3815	COAD	TCGA	DELGNVPEL	DEG_COP1_1	972:980	Mutation rewiring degron network	0.25
p.T983N	TCGA-EO-A3KX	UCEC	TCGA	DELGNVPEL	DEG_COP1_1	972:980	Mutation rewiring degron network	0.25
p.L146S	TCGA-AA-A010	COAD	TCGA	PPPY	ITCH	139:142	Mutation rewiring degron network	0.2222
p.R966H	TCGA-AP-A051	UCEC	TCGA	DELGNVPEL	DEG_COP1_1	972:980	Mutation rewiring degron network	0.1667
p.R966H	TCGA-AX-A1CE	UCEC	TCGA	DELGNVPEL	DEG_COP1_1	972:980	Mutation rewiring degron network	0.1667
p.G147R	TCGA-CZ-5462	KIRC	TCGA	PPPY	ITCH	139:142	Mutation rewiring degron network	0.1944
p.G147R	DO19118	KIRC	ICGC	PPPY	ITCH	139:142	Mutation rewiring degron network	0.1944
p.G975V	TCGA-D3-A2J6	SKCM	TCGA	DELGNVPEL	DEG_COP1_1	972:980	Mutation altering degron motif	0.6421
p.P144H	TCGA-EE-A2MG	SKCM	TCGA	PPPY	ITCH	139:142	Mutation rewiring degron network	0.2778
p.P144H	DO37421	SKCM	ICGC	PPPY	ITCH	139:142	Mutation rewiring degron network	0.2778
p.P130S	TCGA-EE-A3JI	SKCM	TCGA	PPPY	ITCH	139:142	Mutation rewiring degron network	0.0833
p.P130S	DO47268	SKCM	ICGC	PPPY	ITCH	139:142	Mutation rewiring degron network	0.0833
p.P130L	TCGA-EE-A3JI	SKCM	TCGA	PPPY	ITCH	139:142	Mutation rewiring degron network	0.0833
p.P130L	DO47268	SKCM	ICGC	PPPY	ITCH	139:142	Mutation rewiring degron network	0.0833
p.G129W	TCGA-FS-A1ZP	SKCM	TCGA	PPPY	ITCH	139:142	Mutation rewiring degron network	0.0556
p.G129W	DO37703	SKCM	ICGC	PPPY	ITCH	139:142	Mutation rewiring degron network	0.0556
p.L974R	TCGA-SL-A6JA	UCEC	TCGA	DELGNVPEL	DEG_COP1_1	972:980	Mutation altering degron motif	0.7316
p.T148R	DO4000	BRCA	ICGC	PPPY	ITCH	139:142	Mutation rewiring degron network	0.1667
p.V143A	DO222839	COCA	ICGC	PPPY	ITCH	139:142	Mutation rewiring degron network	0.3056
p.G131C	DO229018	LICA	ICGC	PPPY	ITCH	139:142	Mutation rewiring degron network	0.1111
p.W142L	DO229018	LICA	ICGC	PPPY	ITCH	139:142	Mutation altering degron motif	0.7015
p.D149N	DO219567	LIHC	ICGC	PPPY	ITCH	139:142	Mutation rewiring degron network	0.1389
p.M129V	DO231851	LINC	ICGC	PPPY	ITCH	139:142	Mutation rewiring degron network	0.0556
p.L136F	DO220851	MELA	ICGC	PPPY	ITCH	139:142	Mutation rewiring degron network	0.25
p.E137Q	DO27905	ORCA	ICGC	PPPY	ITCH	139:142	Mutation rewiring degron network	0.2778
p.L146W	DO229133	THCA	ICGC	PPPY	ITCH	139:142	Mutation rewiring degron network	0.2222
p.N145H	DO43041	UCEC	ICGC	PPPY	ITCH	139:142	Mutation rewiring degron network	0.25
p.D149Y	DO41361	UCEC	ICGC	PPPY	ITCH	139:142	Mutation rewiring degron network	0.1389
p.P145S	SIDM00007	Other Solid Cancers	GDSC	PPPY	ITCH	139:142	Mutation rewiring degron network	0.25
p.P145S	ACH-001550	Skin Cancer	CCLE	PPPY	ITCH	139:142	Mutation rewiring degron network	0.25
p.P145S	MCC13	skin	COSMIC	PPPY	ITCH	139:142	Mutation rewiring degron network	0.25
p.Y142H	SIDM00537	Colorectal Carcinoma	GDSC	PPPY	ITCH	139:142	Mutation altering degron motif	0.7229
p.Y142H	ACH-001345	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	139:142	Mutation altering degron motif	0.7229
p.Y142H	GP5d	large intestine	COSMIC	PPPY	ITCH	139:142	Mutation altering degron motif	0.7229
p.T989M	SIDM00537	Colorectal Carcinoma	GDSC	DELGNVPEL	DEG_COP1_1	972:980	Mutation rewiring degron network	0.0833
p.T989M	ACH-000982	Colon/Colorectal Cancer	CCLE	DELGNVPEL	DEG_COP1_1	972:980	Mutation rewiring degron network	0.0833
p.T989M	ACH-001345	Colon/Colorectal Cancer	CCLE	DELGNVPEL	DEG_COP1_1	972:980	Mutation rewiring degron network	0.0833
p.T989M	GP5d	large intestine	COSMIC	DELGNVPEL	DEG_COP1_1	972:980	Mutation rewiring degron network	0.0833

Kaplan plot for RASA1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RASA1

UniProt ID: P20936

Entrez ID: 5921

Protein name: Ras GTPase-activating protein 1 (GAP) (GTPase-activating protein) (RasGAP) (Ras p21 protein activator) (p120GAP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RASA1 in