DegronMD

Uniprot ID: P20936

Source protein: Ras GTPase-activating protein 1

Source gene: RASA1

Class: DEG_COP1_1

Location: 972:980

E3 ligase: COP1

DEGRON score: 0.6256

ASA_SCORE: 66.3333

COIL: 0.5972

CONS_SCORE: 0.4251

DSS_SCORE: 0.3816

HELIX: 0.3821

FCONS_SCORE: 1.0077

RIG_SCORE: 0.7396

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T983N	TCGA-AA-3815	COAD	TCGA	DELGNVPEL	DEG_COP1_1	0.25
p.T983N	TCGA-EO-A3KX	UCEC	TCGA	DELGNVPEL	DEG_COP1_1	0.25
p.R966H	TCGA-AP-A051	UCEC	TCGA	DELGNVPEL	DEG_COP1_1	0.1667
p.R966H	TCGA-AX-A1CE	UCEC	TCGA	DELGNVPEL	DEG_COP1_1	0.1667
p.G975V	TCGA-D3-A2J6	SKCM	TCGA	DELGNVPEL	DEG_COP1_1	0.6421
p.L974R	TCGA-SL-A6JA	UCEC	TCGA	DELGNVPEL	DEG_COP1_1	0.7316
p.T989M	SIDM00537	Colorectal Carcinoma	GDSC	DELGNVPEL	DEG_COP1_1	0.0833
p.T989M	ACH-000982	Colon/Colorectal Cancer	CCLE	DELGNVPEL	DEG_COP1_1	0.0833
p.T989M	ACH-001345	Colon/Colorectal Cancer	CCLE	DELGNVPEL	DEG_COP1_1	0.0833
p.T989M	GP5d	large_intestine	COSMIC	DELGNVPEL	DEG_COP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20936	Ras GTPase-activating protein 1	DEG_COP1_1	972:980	DELGNVPEL	COP1	0.6256	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons