DegronMD - Q8WXI2(CNKSR2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M517I	TCGA-09-2044	OV	TCGA	IMGTPVPE	DEG_SCF_FBW7_2	524:531	Mutation rewiring degron network	0.1389
p.M517I	TCGA-09-2044	OV	TCGA	NSPTHYSLLP	CBL_PTK	504:513	Mutation rewiring degron network	0.2222
p.D523Y	TCGA-13-0794	OV	TCGA	IMGTPVPE	DEG_SCF_FBW7_2	524:531	Mutation rewiring degron network	0.3056
p.D523Y	TCGA-13-0794	OV	TCGA	NSPTHYSLLP	CBL_PTK	504:513	Mutation rewiring degron network	0.0556
p.A762D	TCGA-17-Z033	LUAD	TCGA	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.0833
p.Q769H	TCGA-37-4135	LUSC	TCGA	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.2778
p.Q769H	TCGA-37-4135	LUSC	TCGA	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1667
p.Q769H	TCGA-94-8035	LUSC	TCGA	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.2778
p.Q769H	TCGA-94-8035	LUSC	TCGA	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1667
p.Q769H	DO233865	GACA	ICGC	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.2778
p.Q769H	DO233865	GACA	ICGC	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1667
p.Q522L	TCGA-49-AARE	LUAD	TCGA	IMGTPVPE	DEG_SCF_FBW7_2	524:531	Mutation rewiring degron network	0.2778
p.Q522L	TCGA-49-AARE	LUAD	TCGA	NSPTHYSLLP	CBL_PTK	504:513	Mutation rewiring degron network	0.0833
p.P695T	TCGA-52-7622	LUSC	TCGA	PPPY	ITCH	704:707	Mutation rewiring degron network	0.0833
p.P695Q	TCGA-52-7622	LUSC	TCGA	PPPY	ITCH	704:707	Mutation rewiring degron network	0.0833
p.S334F	TCGA-55-7910	LUAD	TCGA	VATPSST	DEG_SCF_FBW7_1	330:336	Mutation altering degron motif	0.6871
p.S334F	DO23669	LUAD	ICGC	VATPSST	DEG_SCF_FBW7_1	330:336	Mutation altering degron motif	0.6871
p.S715W	TCGA-56-8625	LUSC	TCGA	PPPY	ITCH	704:707	Mutation rewiring degron network	0.1111
p.P775S	TCGA-78-8640	LUAD	TCGA	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation altering degron motif	0.6752
p.P775S	TCGA-78-8640	LUAD	TCGA	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation altering degron motif	0.6752
p.P711T	TCGA-86-8674	LUAD	TCGA	PPPY	ITCH	704:707	Mutation rewiring degron network	0.2222
p.P695S	TCGA-91-6831	LUAD	TCGA	PPPY	ITCH	704:707	Mutation rewiring degron network	0.0833
p.S702N	TCGA-AA-3867	COAD	TCGA	PPPY	ITCH	704:707	Mutation rewiring degron network	0.2778
p.P513H	TCGA-AA-3947	COAD	TCGA	NSPTHYSLLP	CBL_PTK	504:513	Mutation altering degron motif	0.7694
p.P513H	TCGA-D3-A3C8	SKCM	TCGA	NSPTHYSLLP	CBL_PTK	504:513	Mutation altering degron motif	0.7694
p.R324I	TCGA-AX-A0J0	UCEC	TCGA	VATPSST	DEG_SCF_FBW7_1	330:336	Mutation rewiring degron network	0.1667
p.R324I	DO41133	UCEC	ICGC	VATPSST	DEG_SCF_FBW7_1	330:336	Mutation rewiring degron network	0.1667
p.N504D	TCGA-AX-A1CE	UCEC	TCGA	NSPTHYSLLP	CBL_PTK	504:513	Mutation altering degron motif	0.5821
p.H508Q	TCGA-B5-A3FA	UCEC	TCGA	NSPTHYSLLP	CBL_PTK	504:513	Mutation altering degron motif	0.647
p.R521S	TCGA-BH-A5IZ	BRCA	TCGA	IMGTPVPE	DEG_SCF_FBW7_2	524:531	Mutation rewiring degron network	0.25
p.R521S	TCGA-BH-A5IZ	BRCA	TCGA	NSPTHYSLLP	CBL_PTK	504:513	Mutation rewiring degron network	0.1111
p.E531K	TCGA-BR-4369	STAD	TCGA	IMGTPVPE	DEG_SCF_FBW7_2	524:531	Mutation altering degron motif	0.7022
p.E531K	DO38659	STAD	ICGC	IMGTPVPE	DEG_SCF_FBW7_2	524:531	Mutation altering degron motif	0.7022
p.Q764R	TCGA-BR-8590	STAD	TCGA	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.1389
p.L515S	TCGA-CG-5721	STAD	TCGA	IMGTPVPE	DEG_SCF_FBW7_2	524:531	Mutation rewiring degron network	0.0833
p.L515S	TCGA-CG-5721	STAD	TCGA	NSPTHYSLLP	CBL_PTK	504:513	Mutation rewiring degron network	0.2778
p.P506Q	TCGA-D3-A1Q3	SKCM	TCGA	NSPTHYSLLP	CBL_PTK	504:513	Mutation altering degron motif	0.5924
p.H536N	TCGA-D3-A3C7	SKCM	TCGA	IMGTPVPE	DEG_SCF_FBW7_2	524:531	Mutation rewiring degron network	0.1944
p.V330I	TCGA-DD-A1EE	LIHC	TCGA	VATPSST	DEG_SCF_FBW7_1	330:336	Mutation altering degron motif	0.5965
p.V330I	DO22857	LIHC	ICGC	VATPSST	DEG_SCF_FBW7_1	330:336	Mutation altering degron motif	0.5965
p.V330I	SIDM01304	Colorectal Carcinoma	GDSC	VATPSST	DEG_SCF_FBW7_1	330:336	Mutation altering degron motif	0.5965
p.R343G	TCGA-DF-A2KN	UCEC	TCGA	VATPSST	DEG_SCF_FBW7_1	330:336	Mutation rewiring degron network	0.1389
p.R343G	DO223282	UCEC	ICGC	VATPSST	DEG_SCF_FBW7_1	330:336	Mutation rewiring degron network	0.1389
p.D708N	TCGA-EE-A2MG	SKCM	TCGA	PPPY	ITCH	704:707	Mutation rewiring degron network	0.3056
p.P705S	TCGA-EE-A3JD	SKCM	TCGA	PPPY	ITCH	704:707	Mutation altering degron motif	0.6752
p.P705S	HCT-116	large intestine	COSMIC	PPPY	ITCH	704:707	Mutation altering degron motif	0.6752
p.Q539K	TCGA-EW-A1IW	BRCA	TCGA	IMGTPVPE	DEG_SCF_FBW7_2	524:531	Mutation rewiring degron network	0.1111
p.P788S	TCGA-G4-6628	COAD	TCGA	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.0556
p.P788S	TCGA-G4-6628	COAD	TCGA	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.0833
p.P788S	SIDM00783	Colorectal Carcinoma	GDSC	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.0556
p.P788S	SIDM00783	Colorectal Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.0833
p.P788S	ACH-000971	Colon/Colorectal Cancer	CCLE	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.0556
p.P788S	ACH-000971	Colon/Colorectal Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.0833
p.P788S	HCT-116	large intestine	COSMIC	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.0556
p.P788S	HCT-116	large intestine	COSMIC	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.0833
p.P698L	TCGA-L5-A8NI	ESCA	TCGA	PPPY	ITCH	704:707	Mutation rewiring degron network	0.1667
p.S503T	TCGA-P3-A6T5	HNSC	TCGA	NSPTHYSLLP	CBL_PTK	504:513	Mutation rewiring degron network	0.3056
p.M716V	TCGA-TQ-A7RN	LGG	TCGA	PPPY	ITCH	704:707	Mutation rewiring degron network	0.0833
p.V529M	TCGA-VQ-A91E	STAD	TCGA	IMGTPVPE	DEG_SCF_FBW7_2	524:531	Mutation altering degron motif	0.6097
p.K711N	DO49976	CESC	ICGC	PPPY	ITCH	704:707	Mutation rewiring degron network	0.2222
p.P774S	DO223732	CESC	ICGC	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation altering degron motif	0.6752
p.P774S	DO222536	MELA	ICGC	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation altering degron motif	0.6752
p.P774S	DO42608	UCEC	ICGC	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation altering degron motif	0.6752
p.R766H	DO222746	COCA	ICGC	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.1944
p.R766H	DO222746	COCA	ICGC	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.0833
p.R766H	SIDM00596	Endometrial Carcinoma	GDSC	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.1944
p.R766H	SIDM00596	Endometrial Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.0833
p.R766H	SIDM00451	T-Lymphoblastic Leukemia	GDSC	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.1944
p.R766H	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.0833
p.R766H	ACH-000937	Leukemia	CCLE	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.1944
p.R766H	ACH-000937	Leukemia	CCLE	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.0833
p.R766H	ACH-001517	Endometrial/Uterine Cancer	CCLE	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.1944
p.R766H	ACH-001517	Endometrial/Uterine Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.0833
p.R766H	HEC-1	endometrium	COSMIC	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.1944
p.R766H	HEC-1	endometrium	COSMIC	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.0833
p.R766H	PF-382	haematopoietic and lymphoid tissue	COSMIC	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.1944
p.R766H	PF-382	haematopoietic and lymphoid tissue	COSMIC	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.0833
p.S510A	DO222798	COCA	ICGC	NSPTHYSLLP	CBL_PTK	504:513	Mutation altering degron motif	0.7588
p.S325R	DO50316	ESAD	ICGC	VATPSST	DEG_SCF_FBW7_1	330:336	Mutation blocking phosphorylation signal	0.6389
p.R716H	DO222601	ESCA	ICGC	PPPY	ITCH	704:707	Mutation rewiring degron network	0.0833
p.R716C	DO233133	GACA	ICGC	PPPY	ITCH	704:707	Mutation rewiring degron network	0.0833
p.A534V	DO233838	GACA	ICGC	IMGTPVPE	DEG_SCF_FBW7_2	524:531	Mutation rewiring degron network	0.25
p.A534V	DO22237	LGG	ICGC	IMGTPVPE	DEG_SCF_FBW7_2	524:531	Mutation rewiring degron network	0.25
p.A534V	DO52659	MALY	ICGC	IMGTPVPE	DEG_SCF_FBW7_2	524:531	Mutation rewiring degron network	0.25
p.A534V	DO36881	READ	ICGC	IMGTPVPE	DEG_SCF_FBW7_2	524:531	Mutation rewiring degron network	0.25
p.Q764H	DO14454	HNSC	ICGC	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.1389
p.E699K	DO14160	HNSC	ICGC	PPPY	ITCH	704:707	Mutation substituting flanking lysine	0.3056
p.G504V	DO15182	HNSC	ICGC	NSPTHYSLLP	CBL_PTK	504:513	Mutation altering degron motif	0.7532
p.S328I	DO229045	LICA	ICGC	VATPSST	DEG_SCF_FBW7_1	330:336	Mutation rewiring degron network	0.2778
p.S338I	DO229045	LICA	ICGC	VATPSST	DEG_SCF_FBW7_1	330:336	Mutation rewiring degron network	0.2778
p.H771D	DO23192	LINC	ICGC	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation altering degron motif	0.7688
p.E525D	DO23818	LUAD	ICGC	IMGTPVPE	DEG_SCF_FBW7_2	524:531	Mutation altering degron motif	0.6758
p.E525D	DO23602	LUAD	ICGC	IMGTPVPE	DEG_SCF_FBW7_2	524:531	Mutation altering degron motif	0.6758
p.L786Q	DO26530	LUSC	ICGC	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.1111
p.L786Q	DO26530	LUSC	ICGC	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1389
p.C524S	DO26752	LUSC	ICGC	IMGTPVPE	DEG_SCF_FBW7_2	524:531	Mutation altering degron motif	0.7541
p.R513Q	DO27381	LUSC	ICGC	NSPTHYSLLP	CBL_PTK	504:513	Mutation altering degron motif	0.7329
p.R513Q	DO222363	MELA	ICGC	NSPTHYSLLP	CBL_PTK	504:513	Mutation altering degron motif	0.7329
p.Q698K	DO27326	LUSC	ICGC	PPPY	ITCH	704:707	Mutation rewiring degron network	0.1667
p.K503N	DO27081	LUSC	ICGC	NSPTHYSLLP	CBL_PTK	504:513	Mutation rewiring degron network	0.3056
p.L519F	DO222413	MELA	ICGC	IMGTPVPE	DEG_SCF_FBW7_2	524:531	Mutation rewiring degron network	0.1944
p.L519F	DO222413	MELA	ICGC	NSPTHYSLLP	CBL_PTK	504:513	Mutation rewiring degron network	0.1667
p.R782K	DO222550	MELA	ICGC	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.2222
p.R782K	DO222550	MELA	ICGC	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.25
p.S704N	DO222696	MELA	ICGC	PPPY	ITCH	704:707	Mutation altering degron motif	0.7069
p.R697H	DO36724	READ	ICGC	PPPY	ITCH	704:707	Mutation rewiring degron network	0.1389
p.P776T	DO47353	SKCM	ICGC	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation altering degron motif	0.7031
p.P776T	DO47353	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation altering degron motif	0.7031
p.E779K	DO37931	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation altering degron motif	0.7022
p.G788E	DO38111	SKCM	ICGC	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.0556
p.G788E	DO38111	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.0833
p.Q715R	DO47779	STAD	ICGC	PPPY	ITCH	704:707	Mutation rewiring degron network	0.1111
p.K500N	DO229259	THCA	ICGC	NSPTHYSLLP	CBL_PTK	504:513	Mutation rewiring degron network	0.2222
p.P505S	DO40884	UCEC	ICGC	NSPTHYSLLP	CBL_PTK	504:513	Mutation altering degron motif	0.6752
p.A705V	DO43899	UCEC	ICGC	PPPY	ITCH	704:707	Mutation altering degron motif	0.6936
p.C766Y	DO41235	UCEC	ICGC	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.1944
p.C766Y	DO41235	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.0833
p.T507A	SIDM00845	Burkitt's Lymphoma	GDSC	NSPTHYSLLP	CBL_PTK	504:513	Mutation altering degron motif	0.6028
p.D770N	SIDM00007	Other Solid Cancers	GDSC	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.3056
p.D770N	SIDM00007	Other Solid Cancers	GDSC	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1944
p.D770N	ACH-001550	Skin Cancer	CCLE	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.3056
p.D770N	ACH-001550	Skin Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1944
p.W768L	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.25
p.W768L	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1389
p.W768L	ACH-000452	Esophageal Cancer	CCLE	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.25
p.W768L	ACH-000452	Esophageal Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1389
p.W768L	TE-8	oesophagus	COSMIC	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.25
p.W768L	TE-8	oesophagus	COSMIC	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1389
p.I337M	SIDM00248	Gastric Carcinoma	GDSC	VATPSST	DEG_SCF_FBW7_1	330:336	Mutation rewiring degron network	0.3056
p.I337M	ACH-000758	Gastric Cancer	CCLE	VATPSST	DEG_SCF_FBW7_1	330:336	Mutation rewiring degron network	0.3056
p.S503N	ACH-000887	Brain Cancer	CCLE	NSPTHYSLLP	CBL_PTK	504:513	Mutation rewiring degron network	0.3056
p.M517T	ACH-001369	Ovarian Cancer	CCLE	IMGTPVPE	DEG_SCF_FBW7_2	524:531	Mutation rewiring degron network	0.1389
p.M517T	ACH-001369	Ovarian Cancer	CCLE	NSPTHYSLLP	CBL_PTK	504:513	Mutation rewiring degron network	0.2222
p.K528E	SNG-M	endometrium	COSMIC	IMGTPVPE	DEG_SCF_FBW7_2	524:531	Mutation altering degron motif	0.7022
p.K509E	SNG-M	endometrium	COSMIC	NSPTHYSLLP	CBL_PTK	504:513	Mutation altering degron motif	0.7022
p.A773V	CML-T1	haematopoietic and lymphoid tissue	COSMIC	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation altering degron motif	0.6936
p.S703N	SNU-175	large intestine	COSMIC	PPPY	ITCH	704:707	Mutation rewiring degron network	0.3056
p.I770V	NCI-H1915	lung	COSMIC	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.3056
p.I770V	NCI-H1915	lung	COSMIC	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1944
p.I770V	CAL-39	vulva	COSMIC	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.3056
p.I770V	CAL-39	vulva	COSMIC	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1944
p.K341E	SNG-M	endometrium	COSMIC	VATPSST	DEG_SCF_FBW7_1	330:336	Mutation rewiring degron network	0.1944
p.A522V	LS-411N	large intestine	COSMIC	IMGTPVPE	DEG_SCF_FBW7_2	524:531	Mutation rewiring degron network	0.2778
p.A522V	LS-411N	large intestine	COSMIC	NSPTHYSLLP	CBL_PTK	504:513	Mutation rewiring degron network	0.0833
p.Q789E	NCI-H2342	lung	COSMIC	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.0556
p.A768V	CML-T1	haematopoietic and lymphoid tissue	COSMIC	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.25
p.A768V	CML-T1	haematopoietic and lymphoid tissue	COSMIC	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1389
p.P708R	LU-135	lung	COSMIC	PPPY	ITCH	704:707	Mutation rewiring degron network	0.3056
p.A514V	FU97	stomach	COSMIC	IMGTPVPE	DEG_SCF_FBW7_2	524:531	Mutation rewiring degron network	0.0556
p.A514V	FU97	stomach	COSMIC	NSPTHYSLLP	CBL_PTK	504:513	Mutation rewiring degron network	0.3056
p.A514V	HT-115	large intestine	COSMIC	IMGTPVPE	DEG_SCF_FBW7_2	524:531	Mutation rewiring degron network	0.0556
p.A514V	HT-115	large intestine	COSMIC	NSPTHYSLLP	CBL_PTK	504:513	Mutation rewiring degron network	0.3056
p.S698N	SNU-175	large intestine	COSMIC	PPPY	ITCH	704:707	Mutation rewiring degron network	0.1667
p.A518V	LS-411N	large intestine	COSMIC	IMGTPVPE	DEG_SCF_FBW7_2	524:531	Mutation rewiring degron network	0.1667
p.A518V	LS-411N	large intestine	COSMIC	NSPTHYSLLP	CBL_PTK	504:513	Mutation rewiring degron network	0.1944
p.S511N	SNU-175	large intestine	COSMIC	NSPTHYSLLP	CBL_PTK	504:513	Mutation altering degron motif	0.7069
p.R508K	SW756	cervix	COSMIC	NSPTHYSLLP	CBL_PTK	504:513	Mutation altering degron motif	0.7237
p.P763S	HCT-116	large intestine	COSMIC	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.1111
p.I775V	NCI-H1915	lung	COSMIC	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation altering degron motif	0.7076
p.I775V	NCI-H1915	lung	COSMIC	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation altering degron motif	0.7076
p.I775V	CAL-39	vulva	COSMIC	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation altering degron motif	0.7076
p.I775V	CAL-39	vulva	COSMIC	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation altering degron motif	0.7076
p.R717H	PF-382	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	704:707	Mutation rewiring degron network	0.0556
p.R717H	HEC-1	endometrium	COSMIC	PPPY	ITCH	704:707	Mutation rewiring degron network	0.0556
p.Y523H	HCT-15	large intestine	COSMIC	IMGTPVPE	DEG_SCF_FBW7_2	524:531	Mutation rewiring degron network	0.3056
p.Y523H	HCT-15	large intestine	COSMIC	NSPTHYSLLP	CBL_PTK	504:513	Mutation rewiring degron network	0.0556
p.Q785E	NCI-H2342	lung	COSMIC	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.1389
p.Q785E	NCI-H2342	lung	COSMIC	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1667
p.H497R	SK-MEL-24	skin	COSMIC	NSPTHYSLLP	CBL_PTK	504:513	Mutation substituting flanking lysine	0.25
p.K533E	SNG-M	endometrium	COSMIC	IMGTPVPE	DEG_SCF_FBW7_2	524:531	Mutation rewiring degron network	0.2778
p.R710H	HT-115	large intestine	COSMIC	PPPY	ITCH	704:707	Mutation rewiring degron network	0.25
p.P709S	HCT-116	large intestine	COSMIC	PPPY	ITCH	704:707	Mutation rewiring degron network	0.2778
p.C501Y	CW-2	large intestine	COSMIC	NSPTHYSLLP	CBL_PTK	504:513	Mutation rewiring degron network	0.25
p.A715V	CML-T1	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	704:707	Mutation rewiring degron network	0.1111
p.H779R	SK-MEL-24	skin	COSMIC	PLTSS	DEG_SPOP_SBC_1	775:779	Mutation altering degron motif	0.8244
p.I717V	NCI-H1915	lung	COSMIC	PPPY	ITCH	704:707	Mutation rewiring degron network	0.0556
p.I717V	CAL-39	vulva	COSMIC	PPPY	ITCH	704:707	Mutation rewiring degron network	0.0556
p.Y527H	HCT-15	large intestine	COSMIC	IMGTPVPE	DEG_SCF_FBW7_2	524:531	Mutation altering degron motif	0.7229
p.H774R	SK-MEL-24	skin	COSMIC	LIETPLTS	DEG_SCF_FBW7_1	771:778	Mutation altering degron motif	0.8244
p.G532V	NCI-H250	lung	COSMIC	IMGTPVPE	DEG_SCF_FBW7_2	524:531	Mutation rewiring degron network	0.3056
p.P540R	LU-135	lung	COSMIC	IMGTPVPE	DEG_SCF_FBW7_2	524:531	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CNKSR2

UniProt ID: Q8WXI2

Entrez ID: 22866

Protein name: Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR 2) (CNK homolog protein 2) (CNK2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CNKSR2 in