DegronMD

Uniprot ID: Q8WXI2

Source protein: Connector enhancer of kinase suppressor of ras 2

Source gene: CNKSR2

Class: CBL_PTK

Location: 504:513

E3 ligase: CBL

DEGRON score: 0.9899

ASA_SCORE: 76.93

COIL: 0.7391

CONS_SCORE: 0.4257

DSS_SCORE: 0.6166

HELIX: 0.1826

FCONS_SCORE: 1.12

RIG_SCORE: 0.6797

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M517I	TCGA-09-2044	OV	TCGA	NSPTHYSLLP	CBL_PTK	0.2222
p.D523Y	TCGA-13-0794	OV	TCGA	NSPTHYSLLP	CBL_PTK	0.0556
p.Q522L	TCGA-49-AARE	LUAD	TCGA	NSPTHYSLLP	CBL_PTK	0.0833
p.P513H	TCGA-AA-3947	COAD	TCGA	NSPTHYSLLP	CBL_PTK	0.7694
p.P513H	TCGA-D3-A3C8	SKCM	TCGA	NSPTHYSLLP	CBL_PTK	0.7694
p.N504D	TCGA-AX-A1CE	UCEC	TCGA	NSPTHYSLLP	CBL_PTK	0.5821
p.H508Q	TCGA-B5-A3FA	UCEC	TCGA	NSPTHYSLLP	CBL_PTK	0.647
p.R521S	TCGA-BH-A5IZ	BRCA	TCGA	NSPTHYSLLP	CBL_PTK	0.1111
p.L515S	TCGA-CG-5721	STAD	TCGA	NSPTHYSLLP	CBL_PTK	0.2778
p.P506Q	TCGA-D3-A1Q3	SKCM	TCGA	NSPTHYSLLP	CBL_PTK	0.5924
p.S503T	TCGA-P3-A6T5	HNSC	TCGA	NSPTHYSLLP	CBL_PTK	0.3056
p.S510A	DO222798	COCA	ICGC	NSPTHYSLLP	CBL_PTK	0.7588
p.G504V	DO15182	HNSC	ICGC	NSPTHYSLLP	CBL_PTK	0.7532
p.R513Q	DO27381	LUSC	ICGC	NSPTHYSLLP	CBL_PTK	0.7329
p.R513Q	DO222363	MELA	ICGC	NSPTHYSLLP	CBL_PTK	0.7329
p.K503N	DO27081	LUSC	ICGC	NSPTHYSLLP	CBL_PTK	0.3056
p.L519F	DO222413	MELA	ICGC	NSPTHYSLLP	CBL_PTK	0.1667
p.K500N	DO229259	THCA	ICGC	NSPTHYSLLP	CBL_PTK	0.2222
p.P505S	DO40884	UCEC	ICGC	NSPTHYSLLP	CBL_PTK	0.6752
p.T507A	SIDM00845	Burkitt's Lymphoma	GDSC	NSPTHYSLLP	CBL_PTK	0.6028
p.S503N	ACH-000887	Brain Cancer	CCLE	NSPTHYSLLP	CBL_PTK	0.3056
p.M517T	ACH-001369	Ovarian Cancer	CCLE	NSPTHYSLLP	CBL_PTK	0.2222
p.K509E	SNG-M	endometrium	COSMIC	NSPTHYSLLP	CBL_PTK	0.7022
p.A522V	LS-411N	large_intestine	COSMIC	NSPTHYSLLP	CBL_PTK	0.0833
p.A514V	FU97	stomach	COSMIC	NSPTHYSLLP	CBL_PTK	0.3056
p.A514V	HT-115	large_intestine	COSMIC	NSPTHYSLLP	CBL_PTK	0.3056
p.A518V	LS-411N	large_intestine	COSMIC	NSPTHYSLLP	CBL_PTK	0.1944
p.S511N	SNU-175	large_intestine	COSMIC	NSPTHYSLLP	CBL_PTK	0.7069
p.R508K	SW756	cervix	COSMIC	NSPTHYSLLP	CBL_PTK	0.7237
p.Y523H	HCT-15	large_intestine	COSMIC	NSPTHYSLLP	CBL_PTK	0.0556
p.H497R	SK-MEL-24	skin	COSMIC	NSPTHYSLLP	CBL_PTK	0.25
p.C501Y	CW-2	large_intestine	COSMIC	NSPTHYSLLP	CBL_PTK	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NSPTHYSLLP

Degron related mutations and impact score

Drug responses associated with CNKSR2 mutations

All proteins holding degron of NSPTHYSLLP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI2	Connector enhancer of kinase suppressor of ras 2	CBL_PTK	504:513	NSPTHYSLLP	CBL	0.9899	More...