DegronMD

Uniprot ID: Q8WXI2

Source protein: Connector enhancer of kinase suppressor of ras 2

Source gene: CNKSR2

Class: DEG_SCF_FBW7_2

Location: 524:531

E3 ligase: FBXW7

DEGRON score: 0.9909

ASA_SCORE: 72.475

COIL: 0.8159

CONS_SCORE: 0.427

DSS_SCORE: 0.4812

HELIX: 0.0611

FCONS_SCORE: 1.0581

RIG_SCORE: 0.7067

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M517I	TCGA-09-2044	OV	TCGA	IMGTPVPE	DEG_SCF_FBW7_2	0.1389
p.D523Y	TCGA-13-0794	OV	TCGA	IMGTPVPE	DEG_SCF_FBW7_2	0.3056
p.Q522L	TCGA-49-AARE	LUAD	TCGA	IMGTPVPE	DEG_SCF_FBW7_2	0.2778
p.R521S	TCGA-BH-A5IZ	BRCA	TCGA	IMGTPVPE	DEG_SCF_FBW7_2	0.25
p.E531K	TCGA-BR-4369	STAD	TCGA	IMGTPVPE	DEG_SCF_FBW7_2	0.7022
p.E531K	DO38659	STAD	ICGC	IMGTPVPE	DEG_SCF_FBW7_2	0.7022
p.L515S	TCGA-CG-5721	STAD	TCGA	IMGTPVPE	DEG_SCF_FBW7_2	0.0833
p.H536N	TCGA-D3-A3C7	SKCM	TCGA	IMGTPVPE	DEG_SCF_FBW7_2	0.1944
p.Q539K	TCGA-EW-A1IW	BRCA	TCGA	IMGTPVPE	DEG_SCF_FBW7_2	0.1111
p.V529M	TCGA-VQ-A91E	STAD	TCGA	IMGTPVPE	DEG_SCF_FBW7_2	0.6097
p.A534V	DO233838	GACA	ICGC	IMGTPVPE	DEG_SCF_FBW7_2	0.25
p.A534V	DO22237	LGG	ICGC	IMGTPVPE	DEG_SCF_FBW7_2	0.25
p.A534V	DO52659	MALY	ICGC	IMGTPVPE	DEG_SCF_FBW7_2	0.25
p.A534V	DO36881	READ	ICGC	IMGTPVPE	DEG_SCF_FBW7_2	0.25
p.E525D	DO23818	LUAD	ICGC	IMGTPVPE	DEG_SCF_FBW7_2	0.6758
p.E525D	DO23602	LUAD	ICGC	IMGTPVPE	DEG_SCF_FBW7_2	0.6758
p.C524S	DO26752	LUSC	ICGC	IMGTPVPE	DEG_SCF_FBW7_2	0.7541
p.L519F	DO222413	MELA	ICGC	IMGTPVPE	DEG_SCF_FBW7_2	0.1944
p.M517T	ACH-001369	Ovarian Cancer	CCLE	IMGTPVPE	DEG_SCF_FBW7_2	0.1389
p.K528E	SNG-M	endometrium	COSMIC	IMGTPVPE	DEG_SCF_FBW7_2	0.7022
p.A522V	LS-411N	large_intestine	COSMIC	IMGTPVPE	DEG_SCF_FBW7_2	0.2778
p.A514V	FU97	stomach	COSMIC	IMGTPVPE	DEG_SCF_FBW7_2	0.0556
p.A514V	HT-115	large_intestine	COSMIC	IMGTPVPE	DEG_SCF_FBW7_2	0.0556
p.A518V	LS-411N	large_intestine	COSMIC	IMGTPVPE	DEG_SCF_FBW7_2	0.1667
p.Y523H	HCT-15	large_intestine	COSMIC	IMGTPVPE	DEG_SCF_FBW7_2	0.3056
p.K533E	SNG-M	endometrium	COSMIC	IMGTPVPE	DEG_SCF_FBW7_2	0.2778
p.Y527H	HCT-15	large_intestine	COSMIC	IMGTPVPE	DEG_SCF_FBW7_2	0.7229
p.G532V	NCI-H250	lung	COSMIC	IMGTPVPE	DEG_SCF_FBW7_2	0.3056
p.P540R	LU-135	lung	COSMIC	IMGTPVPE	DEG_SCF_FBW7_2	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IMGTPVPE

Degron related mutations and impact score

Drug responses associated with CNKSR2 mutations

All proteins holding degron of IMGTPVPE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI2	Connector enhancer of kinase suppressor of ras 2	DEG_SCF_FBW7_2	524:531	IMGTPVPE	FBXW7	0.9909	More...