DegronMD

Uniprot ID: Q8WXI2

Source protein: Connector enhancer of kinase suppressor of ras 2

Source gene: CNKSR2

Class: DEG_SCF_FBW7_1

Location: 330:336

E3 ligase: FBXW7

DEGRON score: 0.9917

ASA_SCORE: 82.9

COIL: 0.9491

CONS_SCORE: 0.4189

DSS_SCORE: 0.6444

HELIX: 0.0286

FCONS_SCORE: 0.9602

RIG_SCORE: 0.6038

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S334F	TCGA-55-7910	LUAD	TCGA	VATPSST	DEG_SCF_FBW7_1	0.6871
p.S334F	DO23669	LUAD	ICGC	VATPSST	DEG_SCF_FBW7_1	0.6871
p.R324I	TCGA-AX-A0J0	UCEC	TCGA	VATPSST	DEG_SCF_FBW7_1	0.1667
p.R324I	DO41133	UCEC	ICGC	VATPSST	DEG_SCF_FBW7_1	0.1667
p.V330I	TCGA-DD-A1EE	LIHC	TCGA	VATPSST	DEG_SCF_FBW7_1	0.5965
p.V330I	DO22857	LIHC	ICGC	VATPSST	DEG_SCF_FBW7_1	0.5965
p.V330I	SIDM01304	Colorectal Carcinoma	GDSC	VATPSST	DEG_SCF_FBW7_1	0.5965
p.R343G	TCGA-DF-A2KN	UCEC	TCGA	VATPSST	DEG_SCF_FBW7_1	0.1389
p.R343G	DO223282	UCEC	ICGC	VATPSST	DEG_SCF_FBW7_1	0.1389
p.S325R	DO50316	ESAD	ICGC	VATPSST	DEG_SCF_FBW7_1	0.6389
p.S328I	DO229045	LICA	ICGC	VATPSST	DEG_SCF_FBW7_1	0.2778
p.S338I	DO229045	LICA	ICGC	VATPSST	DEG_SCF_FBW7_1	0.2778
p.I337M	SIDM00248	Gastric Carcinoma	GDSC	VATPSST	DEG_SCF_FBW7_1	0.3056
p.I337M	ACH-000758	Gastric Cancer	CCLE	VATPSST	DEG_SCF_FBW7_1	0.3056
p.K341E	SNG-M	endometrium	COSMIC	VATPSST	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI2	Connector enhancer of kinase suppressor of ras 2	DEG_SCF_FBW7_1	330:336	VATPSST	FBXW7	0.9917	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2036:2042	VATPSST	FBXW7	0.998	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2593:2599	VATPSST	FBXW7	0.9911	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3293:3299	VATPSST	FBXW7	0.9557	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3850:3856	VATPSST	FBXW7	0.993	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4578:4584	VATPSST	FBXW7	0.9844	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons