DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 3293:3299

E3 ligase: FBXW7

DEGRON score: 0.9557

ASA_SCORE: 91.7

COIL: 0.9423

CONS_SCORE: 0.3407

DSS_SCORE: 0.6454

HELIX: 0.0127

FCONS_SCORE: 0.9512

RIG_SCORE: 0.6447

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P3296S	TCGA-EY-A215	UCEC	TCGA	VATPSST	DEG_SCF_FBW7_1	0.6752
p.G3291S	TCGA-UD-AAC1	MESO	TCGA	VATPSST	DEG_SCF_FBW7_1	0.2778
p.T3287A	DO222809	COCA	ICGC	VATPSST	DEG_SCF_FBW7_1	0.1667
p.T3287A	DO229016	COCA	ICGC	VATPSST	DEG_SCF_FBW7_1	0.1667
p.T3287A	DO229003	COCA	ICGC	VATPSST	DEG_SCF_FBW7_1	0.1667
p.T3287A	DO229005	COCA	ICGC	VATPSST	DEG_SCF_FBW7_1	0.1667
p.P3303Q	DO46376	OV	ICGC	VATPSST	DEG_SCF_FBW7_1	0.2222
p.T3293N	DO229253	THCA	ICGC	VATPSST	DEG_SCF_FBW7_1	0.7055
p.T3286M	DO48174	UCEC	ICGC	VATPSST	DEG_SCF_FBW7_1	0.1389
p.P3299S	DO42665	UCEC	ICGC	VATPSST	DEG_SCF_FBW7_1	0.6752
p.P3296L	SIDM00422	Hodgkin's Lymphoma	GDSC	VATPSST	DEG_SCF_FBW7_1	0.7582
p.P3296L	ACH-001203	Lymphoma	CCLE	VATPSST	DEG_SCF_FBW7_1	0.7582
p.P3296L	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	VATPSST	DEG_SCF_FBW7_1	0.7582
p.R3288S	SIDM01442	Glioma	GDSC	VATPSST	DEG_SCF_FBW7_1	0.1944
p.R3288G	KARPAS-422	haematopoietic_and_lymphoid_tissue	COSMIC	VATPSST	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI2	Connector enhancer of kinase suppressor of ras 2	DEG_SCF_FBW7_1	330:336	VATPSST	FBXW7	0.9917	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2036:2042	VATPSST	FBXW7	0.998	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2593:2599	VATPSST	FBXW7	0.9911	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3293:3299	VATPSST	FBXW7	0.9557	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3850:3856	VATPSST	FBXW7	0.993	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4578:4584	VATPSST	FBXW7	0.9844	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons